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• W2061946593 abstract "Interferon-gamma (IFN-gamma) induces expression of multiple genes in endothelial cells. Retinoic acid-inducible gene-I (RIG-I) encodes a protein belonging to the DExH-box family, but details of its physiological function are not clear. RIG-I is induced in leukemia cells by retinoic acid and in endothelial cells by lipopolysaccharide. In the present study, the authors found that IFN-gamma also induces the expression of RIG-I in human umbilical vein endothelial cells. Induction of RIG-I mRNA by IFN-gamma was not altered by the treatment with cycloheximide or interleukin-4. Fluorescent immunostaining and Western blot analysis revealed cytoplasmic distribution of RIG-I. The in situ endothelium in a normal lung tissue was also found to express RIG-I protein. Although the physiological function of RIG-I is still unknown, induction of RIG-I by IFN-gamma may play an important role in inflammatory or immunological reactions in endothelial cells." @default.
• W2061946593 created "2016-06-24" @default.
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• W2061946593 date "2004-01-01" @default.
• W2061946593 modified "2023-10-16" @default.
• W2061946593 title "Interferon-γ Induces Retinoic Acid–Inducible Gene-I in Endothelial Cells" @default.
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• W2061946593 doi "https://doi.org/10.1080/10623320490512156" @default.
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