FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061952755> ?p ?o ?g. }

• W2061952755 endingPage "812" @default.
• W2061952755 startingPage "803" @default.
• W2061952755 abstract "Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease associated with multiple immunologic abnormalities. Prominent among these is upregulation of type I interferon (IFN)?a powerful immune adjuvant. IFN is, in part, produced in SLE in response to autoantigens in the form of self-nucleic acids and their associated nuclear proteins. Sources of these autoantigens include apoptotic and necrotic cells as well as neutrophils undergoing a specific form of cell death called NETosis. Although plasmacytoid dendritic cells are the main producers of IFN-a, other cells are important regulators of this process. Both genetic and environmental risk factors play a role in the development and pathogenesis of SLE. Further highlighting the importance of IFN, candidate gene and genome-wide association studies have identified a number of genes involved in type I IFN pathways associated with SLE. In this review, 3 monogenic deficiencies that result in lupus-like phenotypes and several polygenic variants that have been consistently associated with SLE are highlighted, and the relationship of these genes to IFN-a production is discussed. Clinical associations of the type I IFN pathway and the use of IFN-blocking agents as therapeutic agents in SLE are also reviewed." @default.
• W2061952755 created "2016-06-24" @default.
• W2061952755 creator A5005493295 @default.
• W2061952755 creator A5075616992 @default.
• W2061952755 date "2011-11-01" @default.
• W2061952755 modified "2023-09-30" @default.
• W2061952755 title "Type I Interferon and Systemic Lupus Erythematosus" @default.
• W2061952755 cites W1552738427 @default.
• W2061952755 cites W1574593386 @default.
• W2061952755 cites W1631384870 @default.
• W2061952755 cites W163644054 @default.
• W2061952755 cites W1848507162 @default.
• W2061952755 cites W1852489937 @default.
• W2061952755 cites W1918778447 @default.
• W2061952755 cites W1965125415 @default.
• W2061952755 cites W1965672602 @default.
• W2061952755 cites W1967844530 @default.
• W2061952755 cites W1969824361 @default.
• W2061952755 cites W1982983059 @default.
• W2061952755 cites W1994094364 @default.
• W2061952755 cites W1999742985 @default.
• W2061952755 cites W2003790326 @default.
• W2061952755 cites W2004869463 @default.
• W2061952755 cites W2011163458 @default.
• W2061952755 cites W2015618907 @default.
• W2061952755 cites W2019916852 @default.
• W2061952755 cites W2021287992 @default.
• W2061952755 cites W2022953233 @default.
• W2061952755 cites W2026255377 @default.
• W2061952755 cites W2029653107 @default.
• W2061952755 cites W2031355052 @default.
• W2061952755 cites W2031848223 @default.
• W2061952755 cites W2037435076 @default.
• W2061952755 cites W2043959346 @default.
• W2061952755 cites W2046383867 @default.
• W2061952755 cites W2048791273 @default.
• W2061952755 cites W2049858255 @default.
• W2061952755 cites W2059705136 @default.
• W2061952755 cites W2062555719 @default.
• W2061952755 cites W2062713016 @default.
• W2061952755 cites W2068197701 @default.
• W2061952755 cites W2070588678 @default.
• W2061952755 cites W2075283457 @default.
• W2061952755 cites W2076032448 @default.
• W2061952755 cites W2076690763 @default.
• W2061952755 cites W2080677705 @default.
• W2061952755 cites W2080775789 @default.
• W2061952755 cites W2088456748 @default.
• W2061952755 cites W2089008855 @default.
• W2061952755 cites W2089678050 @default.
• W2061952755 cites W2092606926 @default.
• W2061952755 cites W2094619835 @default.
• W2061952755 cites W2097556922 @default.
• W2061952755 cites W2102975150 @default.
• W2061952755 cites W2104934425 @default.
• W2061952755 cites W2106273198 @default.
• W2061952755 cites W2109231206 @default.
• W2061952755 cites W2119738935 @default.
• W2061952755 cites W2121592594 @default.
• W2061952755 cites W2127198764 @default.
• W2061952755 cites W2134595043 @default.
• W2061952755 cites W2136590838 @default.
• W2061952755 cites W2137274211 @default.
• W2061952755 cites W2138284015 @default.
• W2061952755 cites W2145812105 @default.
• W2061952755 cites W2145978988 @default.
• W2061952755 cites W2146230109 @default.
• W2061952755 cites W2147843065 @default.
• W2061952755 cites W2148930555 @default.
• W2061952755 cites W2149233112 @default.
• W2061952755 cites W2150932450 @default.
• W2061952755 cites W2153301367 @default.
• W2061952755 cites W2155102587 @default.
• W2061952755 cites W2159402147 @default.
• W2061952755 cites W2162082073 @default.
• W2061952755 cites W2167317609 @default.
• W2061952755 cites W2167940772 @default.
• W2061952755 cites W2168888135 @default.
• W2061952755 cites W2318971911 @default.
• W2061952755 cites W4292083220 @default.
• W2061952755 cites W62156454 @default.
• W2061952755 doi "https://doi.org/10.1089/jir.2011.0045" @default.
• W2061952755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3216059" @default.
• W2061952755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21859344" @default.
• W2061952755 hasPublicationYear "2011" @default.
• W2061952755 type Work @default.
• W2061952755 sameAs 2061952755 @default.
• W2061952755 citedByCount "99" @default.
• W2061952755 countsByYear W20619527552012 @default.
• W2061952755 countsByYear W20619527552013 @default.
• W2061952755 countsByYear W20619527552014 @default.
• W2061952755 countsByYear W20619527552015 @default.
• W2061952755 countsByYear W20619527552016 @default.
• W2061952755 countsByYear W20619527552017 @default.
• W2061952755 countsByYear W20619527552018 @default.
• W2061952755 countsByYear W20619527552019 @default.
• W2061952755 countsByYear W20619527552020 @default.
• W2061952755 countsByYear W20619527552021 @default.

• next