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• W2061960213 abstract "Many heterogeneities exist in Alzheimer's disease (AD) with regard to age of symptom onset, genetic, neuropathological, and neuropsychological aspects. AD patients with an early onset demonstrate a faster progression and a more severe clinical presentation than those with a late onset. ApoE4 is major risk factor for AD and lowering the age at disease onset. The aims of this study were (1) to compare the overall regional cerebral glucose metabolism (rCMRglc) between early onset and late onset AD; and (2) to investigate the possible impact of ApoE genotype on rCMRglc of AD patients according to their onset of age. 92 mild AD patients (age: 67 ± 8; MMSE score: 24 ± 4; Mean ± SD, ApoE4 carriers (+/–): 58/34) were recruited to the study. AD patients divided in two groups according to their age of symptom onset, 35 patients with early onset AD (≤65 years old) (age: 58 ± 5, MMSE score: 24 ± 5, ApoE4 carriers (+/–): 22/13) and 57 patients in late onset group (>65 years old) (age: 73 ± 5, MMSE score: 24 ± 4, ApoE4 carriers (+/–): 36/21). All the subjects underwent 18F FDG–PET and the PET data were analyzed with Region Of Interest (ROI) analysis. In the early onset AD patients, significantly lower glucose metabolism was found in the parietal cortex compared to the late onset group. In the late onset group, anterior cingulate cortex and uncus showed significantly hypometabolism compared to early onset. In the early onset group, the AD patients carrying one or two ϵ4 alleles showed a significantly decrease of rCMRglc in the anterior cingulate cortex, posterior inferior temporal cortex and posterior uncus compared with those patients with ApoE4 non–carrier. In the late onset group, ApoE4 carriers showed significant higher glucose metabolism mainly in the upper parietal cortex, anterior inferior temporal cortex, anterior lateral temporal cortex and posterior uncus compared to ApoE4 non–carriers. Regional glucose metabolism analysis shows different pattern of hypometabolism in the early and late onset AD. The impact of the ApoE ϵ4 genotype on rCMRglc of patients with AD is dependent on age of symptom onset." @default.
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• W2061960213 date "2006-07-01" @default.
• W2061960213 modified "2023-10-02" @default.
• W2061960213 title "IC-P-010: Age and ApoE interaction in Alzheimer's disease: FDG PET study" @default.
• W2061960213 doi "https://doi.org/10.1016/j.jalz.2006.05.2215" @default.
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