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- W2061971880 endingPage "184" @default.
- W2061971880 startingPage "172" @default.
- W2061971880 abstract "alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. The protein has been found in a number of vertebrate species including frogs and fish. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. A gene in the lipocalin cluster encodes alpha(1)-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. alpha(1)-Microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. alpha(1)-Microglobulin inhibits immunological functions of white blood cells in vitro, and its distribution is consistent with an anti-inflammatory and protective role in vivo." @default.
- W2061971880 created "2016-06-24" @default.
- W2061971880 creator A5007727541 @default.
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- W2061971880 creator A5041902578 @default.
- W2061971880 creator A5068276717 @default.
- W2061971880 creator A5073661555 @default.
- W2061971880 date "2000-10-01" @default.
- W2061971880 modified "2023-10-09" @default.
- W2061971880 title "α1-Microglobulin: a yellow-brown lipocalin" @default.
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