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• W2061974967 abstract "Background —The purpose of this study was to determine the effects of systemic exercise training on endothelium-mediated arteriolar vasodilation of the lower limb and its relation to exercise capacity in chronic heart failure (CHF). Endothelial dysfunction is a key feature of CHF, contributing to increased peripheral vasoconstriction and impaired exercise capacity. Local handgrip exercise has previously been shown to enhance endothelium-dependent vasodilation in conduit and resistance vessels in CHF. Methods and Results —Twenty patients were prospectively randomized to a training group (n=10, left ventricular ejection fraction [LVEF] 24±4%) or a control group (n=10, LVEF 23±3%). At baseline and after 6 months, peak flow velocity was measured in the left femoral artery using a Doppler wire; vessel diameter was determined by quantitative angiography. Peripheral blood flow was calculated from average peak velocity (APV) and arterial cross-sectional area. After exercise training, nitroglycerin-induced endothelium-independent vasodilation remained unaltered (271% versus 281%, P =NS). Peripheral blood flow improved significantly in response to 90 μg/min acetylcholine by 203% (from 152±79 to 461±104 mL/min, P <0.05 versus control group) and the inhibiting effect of L-NMMA increased by 174% (from −46±25 to −126±19 mL/min, P <0.05 versus control group). Peak oxygen uptake increased by 26% ( P <0.01 versus control group). The increase in peak oxygen uptake was correlated with the endothelium-dependent change in peripheral blood flow (r=0.64, P <0.005). Conclusions —Regular physical exercise improves both basal endothelial nitric oxide (NO) formation and agonist-mediated endothelium-dependent vasodilation of the skeletal muscle vasculature in patients with CHF. The correction of endothelium dysfunction is associated with a significant increase in exercise capacity." @default.
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• W2061974967 date "1998-12-15" @default.
• W2061974967 modified "2023-10-11" @default.
• W2061974967 title "Regular Physical Exercise Corrects Endothelial Dysfunction and Improves Exercise Capacity in Patients With Chronic Heart Failure" @default.
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• W2061974967 doi "https://doi.org/10.1161/01.cir.98.24.2709" @default.
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