FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061985251> ?p ?o ?g. }

• W2061985251 endingPage "346" @default.
• W2061985251 startingPage "339" @default.
• W2061985251 abstract "Background The activation of the epidermal growth factor family of receptors may improve cardiac protection after injury. One epidermal growth factor family ligand, transforming growth factor-alpha, promotes wound healing in multiple tissues in response to oxidative injury and might confer resistance to myocardial depressant factors, although the role of transforming growth factor-alpha in myocardial ischemia/reperfusion injury is unknown. We hypothesized that preischemic infusion of transforming growth factor-alpha would improve myocardial functional recovery after acute ischemia/reperfusion. Methods The hearts from adult male rats were isolated and perfused via the Langendorff model. Immediately prior to ischemia, the hearts received an intracoronary infusion of either vehicle or transforming growth factor-alpha (1 ng, 10 ng, or 100 ng). After reperfusion, the hearts were assessed for activation of the prosurvival pathway, Akt. Results Infusion of transforming growth factor-alpha did not confer any additional functional protection compared with the vehicle, but myocardial tissue analysis revealed significantly increased activation of the Akt pathway in both the 10-ng and 100-ng groups. Conclusion Preischemic infusion of transforming growth factor-alpha does not improve myocardial functional recovery after ischemia/reperfusion injury. Whereas transforming growth factor-alpha treatment does affect actions at the molecular level, these actions do not translate into an observable functional effect. This lack of improvement may point to a relative unimportance of transforming growth factor-alpha in myocardial signaling compared with other epidermal growth factor ligands. The activation of the epidermal growth factor family of receptors may improve cardiac protection after injury. One epidermal growth factor family ligand, transforming growth factor-alpha, promotes wound healing in multiple tissues in response to oxidative injury and might confer resistance to myocardial depressant factors, although the role of transforming growth factor-alpha in myocardial ischemia/reperfusion injury is unknown. We hypothesized that preischemic infusion of transforming growth factor-alpha would improve myocardial functional recovery after acute ischemia/reperfusion. The hearts from adult male rats were isolated and perfused via the Langendorff model. Immediately prior to ischemia, the hearts received an intracoronary infusion of either vehicle or transforming growth factor-alpha (1 ng, 10 ng, or 100 ng). After reperfusion, the hearts were assessed for activation of the prosurvival pathway, Akt. Infusion of transforming growth factor-alpha did not confer any additional functional protection compared with the vehicle, but myocardial tissue analysis revealed significantly increased activation of the Akt pathway in both the 10-ng and 100-ng groups. Preischemic infusion of transforming growth factor-alpha does not improve myocardial functional recovery after ischemia/reperfusion injury. Whereas transforming growth factor-alpha treatment does affect actions at the molecular level, these actions do not translate into an observable functional effect. This lack of improvement may point to a relative unimportance of transforming growth factor-alpha in myocardial signaling compared with other epidermal growth factor ligands." @default.
• W2061985251 created "2016-06-24" @default.
• W2061985251 creator A5008842860 @default.
• W2061985251 creator A5013438877 @default.
• W2061985251 creator A5015322409 @default.
• W2061985251 creator A5016836659 @default.
• W2061985251 creator A5018600971 @default.
• W2061985251 creator A5030838551 @default.
• W2061985251 creator A5036836207 @default.
• W2061985251 creator A5056097730 @default.
• W2061985251 creator A5076314648 @default.
• W2061985251 creator A5085278984 @default.
• W2061985251 date "2011-08-01" @default.
• W2061985251 modified "2023-09-27" @default.
• W2061985251 title "Transforming growth factor-alpha does not protect myocardium during acute ischemia/reperfusion" @default.
• W2061985251 cites W1938652312 @default.
• W2061985251 cites W1963690717 @default.
• W2061985251 cites W1987108079 @default.
• W2061985251 cites W1996830417 @default.
• W2061985251 cites W2000255289 @default.
• W2061985251 cites W2021253052 @default.
• W2061985251 cites W2031944234 @default.
• W2061985251 cites W2034182103 @default.
• W2061985251 cites W2043173541 @default.
• W2061985251 cites W2044187616 @default.
• W2061985251 cites W2053174155 @default.
• W2061985251 cites W2061484951 @default.
• W2061985251 cites W2093300538 @default.
• W2061985251 cites W2095105499 @default.
• W2061985251 cites W2108097349 @default.
• W2061985251 cites W2112469957 @default.
• W2061985251 cites W2117869971 @default.
• W2061985251 cites W2136139091 @default.
• W2061985251 cites W2140907912 @default.
• W2061985251 cites W2143633028 @default.
• W2061985251 cites W2147485426 @default.
• W2061985251 cites W2154870995 @default.
• W2061985251 cites W2155958456 @default.
• W2061985251 cites W2405731500 @default.
• W2061985251 cites W3022691628 @default.
• W2061985251 cites W96597366 @default.
• W2061985251 doi "https://doi.org/10.1016/j.surg.2011.05.018" @default.
• W2061985251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21801969" @default.
• W2061985251 hasPublicationYear "2011" @default.
• W2061985251 type Work @default.
• W2061985251 sameAs 2061985251 @default.
• W2061985251 citedByCount "1" @default.
• W2061985251 countsByYear W20619852512017 @default.
• W2061985251 crossrefType "journal-article" @default.
• W2061985251 hasAuthorship W2061985251A5008842860 @default.
• W2061985251 hasAuthorship W2061985251A5013438877 @default.
• W2061985251 hasAuthorship W2061985251A5015322409 @default.
• W2061985251 hasAuthorship W2061985251A5016836659 @default.
• W2061985251 hasAuthorship W2061985251A5018600971 @default.
• W2061985251 hasAuthorship W2061985251A5030838551 @default.
• W2061985251 hasAuthorship W2061985251A5036836207 @default.
• W2061985251 hasAuthorship W2061985251A5056097730 @default.
• W2061985251 hasAuthorship W2061985251A5076314648 @default.
• W2061985251 hasAuthorship W2061985251A5085278984 @default.
• W2061985251 hasConcept C118131993 @default.
• W2061985251 hasConcept C125555471 @default.
• W2061985251 hasConcept C126322002 @default.
• W2061985251 hasConcept C134018914 @default.
• W2061985251 hasConcept C159048773 @default.
• W2061985251 hasConcept C170493617 @default.
• W2061985251 hasConcept C2775960820 @default.
• W2061985251 hasConcept C2776362946 @default.
• W2061985251 hasConcept C2779438470 @default.
• W2061985251 hasConcept C2780114680 @default.
• W2061985251 hasConcept C541997718 @default.
• W2061985251 hasConcept C71924100 @default.
• W2061985251 hasConceptScore W2061985251C118131993 @default.
• W2061985251 hasConceptScore W2061985251C125555471 @default.
• W2061985251 hasConceptScore W2061985251C126322002 @default.
• W2061985251 hasConceptScore W2061985251C134018914 @default.
• W2061985251 hasConceptScore W2061985251C159048773 @default.
• W2061985251 hasConceptScore W2061985251C170493617 @default.
• W2061985251 hasConceptScore W2061985251C2775960820 @default.
• W2061985251 hasConceptScore W2061985251C2776362946 @default.
• W2061985251 hasConceptScore W2061985251C2779438470 @default.
• W2061985251 hasConceptScore W2061985251C2780114680 @default.
• W2061985251 hasConceptScore W2061985251C541997718 @default.
• W2061985251 hasConceptScore W2061985251C71924100 @default.
• W2061985251 hasIssue "2" @default.
• W2061985251 hasLocation W20619852511 @default.
• W2061985251 hasLocation W20619852512 @default.
• W2061985251 hasOpenAccess W2061985251 @default.
• W2061985251 hasPrimaryLocation W20619852511 @default.
• W2061985251 hasRelatedWork W1969405162 @default.
• W2061985251 hasRelatedWork W2040202657 @default.
• W2061985251 hasRelatedWork W2049319935 @default.
• W2061985251 hasRelatedWork W2058088002 @default.
• W2061985251 hasRelatedWork W2061985251 @default.
• W2061985251 hasRelatedWork W2121600179 @default.
• W2061985251 hasRelatedWork W2127649347 @default.
• W2061985251 hasRelatedWork W2396929742 @default.
• W2061985251 hasRelatedWork W2413996108 @default.
• W2061985251 hasRelatedWork W2586422822 @default.

• next