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- W2061993413 endingPage "801" @default.
- W2061993413 startingPage "789" @default.
- W2061993413 abstract "Basophils were discovered by Paul Ehrlich in 1879 and represent the least abundant granulocyte population in mammals. The relative rarity of basophils and their phenotypic similarities with mast cells resulted in this cell lineage being historically overlooked, both clinically and experimentally. However, recent studies in human subjects and murine systems have shown that basophils perform nonredundant effector functions and significantly contribute to the development and progression of TH2 cytokine-mediated inflammation. Although the potential functions of murine and human basophils have provoked some controversy, recent genetic approaches indicate that basophils can migrate into lymphoid tissues and, in some circumstances, cooperate with other immune cells to promote optimal TH2 cytokine responses in vivo. This article provides a brief historical perspective on basophil-related research and discusses recent studies that have identified previously unappreciated molecules and pathways that regulate basophil development, activation, and function in the context of allergic inflammation. Furthermore, we highlight the unique effector functions of basophils and discuss their contributions to the development and pathogenesis of allergic inflammation in human disease. Finally, we discuss the therapeutic potential of targeting basophils in preventing or alleviating the development and progression of allergic inflammation." @default.
- W2061993413 created "2016-06-24" @default.
- W2061993413 creator A5001769876 @default.
- W2061993413 creator A5005500510 @default.
- W2061993413 creator A5047011247 @default.
- W2061993413 creator A5062711393 @default.
- W2061993413 date "2013-10-01" @default.
- W2061993413 modified "2023-10-03" @default.
- W2061993413 title "Basophils and allergic inflammation" @default.
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