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• W2061993774 abstract "Mastication may be able to activate endogenous pain inhibitory mechanisms and therefore lead to modulation of nociceptive processing. The purpose of this study was to examine the possible effect of food consistency on noxious input from the spinal system.Three groups of adult male Sprague-Dawley rats were given an injection of complete Freund adjuvant in a hind paw 10 days after eating soft or hard food (one group received a saline injection—the control group [C]; the other group (D) received no injection). Nocifensive behavior was assessed with the use of the hot plate and tail flick assays at 1, 3, 6, and 12 hours and at 6.5 days after injection for groups A/B, and c-Fos activity was assessed in the brain after testing. Groups C/D had hot plate testing at 1 hour and 6.5 days. The data were analyzed by general linear modeling and 1-way analysis of variance.There was a small increase in the hot plate percent maximum possible effect (MPE) from −45.7 to −61.1 in group A over the length of the experiment, but a very small decrease for group B over the same period (−33.5 to −28.8). For the saline control group, there was a small increase toward 0 %MPE over the same time frame (−15.0 to 1.7). The %MPE differences were significant between groups A and C (P < .0005), but not significant between the other groups (F = 13.34, df = 2, P = .001, observed power = 99%). Using the pooled results (all time points), the differences between all groups were significant (P < .0005). There were no significant differences in the tail flick test. c-Fos was mainly observed in the raphe pallidus area with significant differences between groups A and B at 3 and 6 hours after injection of CFA (P = .027 and .022, respectively).The results of this study indicate that food consistency (hardness) influences nocifensive behavior in this animal model via a descending pathway operating at the supraspinal level." @default.
• W2061993774 created "2016-06-24" @default.
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• W2061993774 date "2003-08-01" @default.
• W2061993774 modified "2023-09-25" @default.
• W2061993774 title "Pain: the past, present and future" @default.
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• W2061993774 doi "https://doi.org/10.1016/s0169-409x(03)00096-6" @default.
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