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- W2061994498 abstract "Many studies with chronic stress, a common depression paradigm, lead to inconsistent behavioral results. We are introducing a new model of stress-induced anhedonia, which provides more reproducible induction and behavioral measuring of depressive-like phenotype in mice. First, a 4-week stress procedure induces anhedonia, defined by decreased sucrose preference, in the majority of but not all C57BL/6 mice. The remaining 30–50% non-anhedonic animals are used as an internal control for stress effects that are unrelated to anhedonia. Next, a modified sucrose test enables the detection of inter-individual differences in mice. Moreover, testing under dimmed lighting precludes behavioral artifacts caused by hyperlocomotion, a major confounding factor in stressed mice. Finally, moderation of the stress load increases the reproducibility of anhedonia induction, which otherwise is difficult to provide because of inter-batch variability in laboratory mice. We believe that our new mouse model overcomes some major difficulties in measuring behavior with chronic stress depression models." @default.
- W2061994498 created "2016-06-24" @default.
- W2061994498 creator A5004432345 @default.
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- W2061994498 date "2010-03-01" @default.
- W2061994498 modified "2023-10-07" @default.
- W2061994498 title "Measuring behavior in mice with chronic stress depression paradigm" @default.
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- W2061994498 doi "https://doi.org/10.1016/j.pnpbp.2009.12.014" @default.
- W2061994498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20026369" @default.
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