FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061996381> ?p ?o ?g. }

• W2061996381 endingPage "151" @default.
• W2061996381 startingPage "141" @default.
• W2061996381 abstract "The present study attempted to explore the gene expression of the subunits (GluR1–4) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor, subunit (GluR5) of kainic acid (KA)-type receptor, NR1 [a subunit of N- methyl- d -aspartate (NMDA) receptors] and the possible glutamate-binding subunit of an NMDA receptor complex in the dorsal horn of the rat spinal cords using in situ hybridization histochemistry. These results were compared with those of the spinal motor neurons. Expression of the subunits of the AMPA-type receptor was also examined at the protein level using immunocytochemistry, with reference to the motor neurons. Although all the four subunits of the AMPA-type receptor were expressed throughout the dorsal horn, the pattern of expression was different according to the dorsal horn region and to the subunits. GluR2 showed the strongest expression in the dorsal horn. Huge numbers of strongly labelled cells formed a dense collection in lamina II and superficial parts of lamina III. Many neurons in lamina II and superficial parts of lamina III expressed GluR1 moderately. Scattered neurons moderately expressing GluR3 were also seen in these regions, while the expression of GluR4 was very low. Labelling of the dorsal horn neurons by the GluR5 probe was low, and NR1 probe and a glutamate-binding subunit of an NMDA receptor complex probe labelled them diffusely with low to moderate intensity. These findings show a close relationship between the glutamergic nociceptive primary afferent system and AMPA-type receptors in which GluR2 is especially highly expressed. The present study further showed that the expression pattern of the glutamate receptors in the spinal sensory neurons differs considerably from that of spinal motor neurons. Motor neurons very strongly express GluR3 and 4, while the expression of GluR2 and GluR1 is moderate and low, respectively. Expression of GluR5 is also low in the motor neurons. However, expression of NR1 and the glutamate-binding subunit of an NMDA receptor complex is very strong. These findings indicate that the subunit composition of the AMPA-type receptors regulating motor neurons is different from that of the AMPA-type receptors in the spinal sensory neurons, and that there are at least two kinds of glutamergic systems which regulate motor neurons: via AMPA-type receptors and via NMDA receptors." @default.
• W2061996381 created "2016-06-24" @default.
• W2061996381 creator A5001774118 @default.
• W2061996381 creator A5014130986 @default.
• W2061996381 creator A5038560837 @default.
• W2061996381 creator A5045125241 @default.
• W2061996381 creator A5047677413 @default.
• W2061996381 creator A5050788544 @default.
• W2061996381 creator A5075627852 @default.
• W2061996381 date "1993-04-01" @default.
• W2061996381 modified "2023-10-16" @default.
• W2061996381 title "Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception" @default.
• W2061996381 cites W1504992746 @default.
• W2061996381 cites W1524203275 @default.
• W2061996381 cites W1544134829 @default.
• W2061996381 cites W1548600249 @default.
• W2061996381 cites W1567544633 @default.
• W2061996381 cites W1906221302 @default.
• W2061996381 cites W1963737940 @default.
• W2061996381 cites W1975741189 @default.
• W2061996381 cites W1977529115 @default.
• W2061996381 cites W1978817835 @default.
• W2061996381 cites W1980642537 @default.
• W2061996381 cites W1986178615 @default.
• W2061996381 cites W1986444444 @default.
• W2061996381 cites W1988006134 @default.
• W2061996381 cites W1996449721 @default.
• W2061996381 cites W1996712322 @default.
• W2061996381 cites W1999968276 @default.
• W2061996381 cites W2006406301 @default.
• W2061996381 cites W2013067874 @default.
• W2061996381 cites W2014584100 @default.
• W2061996381 cites W2019430927 @default.
• W2061996381 cites W2029798646 @default.
• W2061996381 cites W2030377238 @default.
• W2061996381 cites W2035331415 @default.
• W2061996381 cites W2037335023 @default.
• W2061996381 cites W2037679337 @default.
• W2061996381 cites W2038471077 @default.
• W2061996381 cites W2039369655 @default.
• W2061996381 cites W2045171292 @default.
• W2061996381 cites W2047111063 @default.
• W2061996381 cites W2050391960 @default.
• W2061996381 cites W2052019848 @default.
• W2061996381 cites W2052932636 @default.
• W2061996381 cites W2053980736 @default.
• W2061996381 cites W2058615066 @default.
• W2061996381 cites W2059334396 @default.
• W2061996381 cites W2063435429 @default.
• W2061996381 cites W2063461600 @default.
• W2061996381 cites W2065269605 @default.
• W2061996381 cites W2065315329 @default.
• W2061996381 cites W2075670113 @default.
• W2061996381 cites W2080822643 @default.
• W2061996381 cites W2080869223 @default.
• W2061996381 cites W2082474912 @default.
• W2061996381 cites W2086586468 @default.
• W2061996381 cites W2099597342 @default.
• W2061996381 cites W2100040827 @default.
• W2061996381 cites W2129851648 @default.
• W2061996381 cites W2148225640 @default.
• W2061996381 cites W2180941170 @default.
• W2061996381 cites W2464097218 @default.
• W2061996381 cites W2594144189 @default.
• W2061996381 doi "https://doi.org/10.1016/0169-328x(93)90183-p" @default.
• W2061996381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8097549" @default.
• W2061996381 hasPublicationYear "1993" @default.
• W2061996381 type Work @default.
• W2061996381 sameAs 2061996381 @default.
• W2061996381 citedByCount "185" @default.
• W2061996381 countsByYear W20619963812012 @default.
• W2061996381 countsByYear W20619963812013 @default.
• W2061996381 countsByYear W20619963812014 @default.
• W2061996381 countsByYear W20619963812017 @default.
• W2061996381 countsByYear W20619963812018 @default.
• W2061996381 countsByYear W20619963812019 @default.
• W2061996381 countsByYear W20619963812020 @default.
• W2061996381 crossrefType "journal-article" @default.
• W2061996381 hasAuthorship W2061996381A5001774118 @default.
• W2061996381 hasAuthorship W2061996381A5014130986 @default.
• W2061996381 hasAuthorship W2061996381A5038560837 @default.
• W2061996381 hasAuthorship W2061996381A5045125241 @default.
• W2061996381 hasAuthorship W2061996381A5047677413 @default.
• W2061996381 hasAuthorship W2061996381A5050788544 @default.
• W2061996381 hasAuthorship W2061996381A5075627852 @default.
• W2061996381 hasConcept C104292427 @default.
• W2061996381 hasConcept C104317684 @default.
• W2061996381 hasConcept C115955781 @default.
• W2061996381 hasConcept C150194340 @default.
• W2061996381 hasConcept C153911025 @default.
• W2061996381 hasConcept C15490471 @default.
• W2061996381 hasConcept C160268369 @default.
• W2061996381 hasConcept C169760540 @default.
• W2061996381 hasConcept C170493617 @default.
• W2061996381 hasConcept C189184402 @default.
• W2061996381 hasConcept C2776108384 @default.
• W2061996381 hasConcept C2780775167 @default.
• W2061996381 hasConcept C2781001490 @default.

• next