Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061999024> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2061999024 endingPage "481" @default.
- W2061999024 startingPage "475" @default.
- W2061999024 abstract "Sphingosine and other protein kinase C inhibitors were tested for their ability to inhibit aldosterone synthesis by bovine adrenal glomerulosa cells. Sphingosine inhibited angiotensin (AII)-stimulated aldosterone synthesis (IC50 of 5 microM). At doses that totally blocked steroidogenesis, sphingosine did not affect protein synthesis or [125I]AII binding to cells. Sphingosine also inhibited dibutyryl cyclic AMP (dbcAMP)-stimulated aldosterone synthesis. Sphingosine inhibited pregnenolone synthesis from cholesterol, but not the conversion of progesterone or 20 alpha-hydroxycholesterol to aldosterone. These results suggest that sphingosine inhibits steroidogenesis at a locus close to that where stimulation occurs by AII and dbcAMP. Other protein kinase C inhibitors were tested. Retinal, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7), and staurosporine inhibited aldosterone synthesis stimulated by AII and dbcAMP. Retinal and H-7 also inhibited progesterone conversion to aldosterone, and retinal blocked [125I]AII binding. Staurosporine was more specific, inhibiting AII-stimulated aldosteronogenesis at concentrations which had little effect on conversion of progesterone to aldosterone. Because they inhibited dbcAMP stimulation, none of the inhibitors was sufficiently specific to use as a probe of the role of protein kinase C. The IC50 of sphingosine suggests that this or related products of lipid hydrolysis could act as endogenous regulators of adrenal cell function." @default.
- W2061999024 created "2016-06-24" @default.
- W2061999024 creator A5075762505 @default.
- W2061999024 creator A5079026280 @default.
- W2061999024 creator A5081269201 @default.
- W2061999024 creator A5087138716 @default.
- W2061999024 date "1991-04-01" @default.
- W2061999024 modified "2023-10-14" @default.
- W2061999024 title "Sphingosine inhibits angiotensin-stimulated aldosterone synthesis" @default.
- W2061999024 cites W1497210970 @default.
- W2061999024 cites W1505323253 @default.
- W2061999024 cites W1524495054 @default.
- W2061999024 cites W1577542502 @default.
- W2061999024 cites W158926978 @default.
- W2061999024 cites W1589866689 @default.
- W2061999024 cites W1595133660 @default.
- W2061999024 cites W1602448176 @default.
- W2061999024 cites W1968643109 @default.
- W2061999024 cites W1973454785 @default.
- W2061999024 cites W1973891524 @default.
- W2061999024 cites W1995580119 @default.
- W2061999024 cites W2006194428 @default.
- W2061999024 cites W2023596188 @default.
- W2061999024 cites W2028614445 @default.
- W2061999024 cites W2040186847 @default.
- W2061999024 cites W2061574494 @default.
- W2061999024 cites W2065471510 @default.
- W2061999024 cites W2090404354 @default.
- W2061999024 cites W2092085238 @default.
- W2061999024 cites W2137320138 @default.
- W2061999024 cites W2170466196 @default.
- W2061999024 cites W2414846215 @default.
- W2061999024 cites W90882140 @default.
- W2061999024 doi "https://doi.org/10.1016/0960-0760(91)90335-3" @default.
- W2061999024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1851631" @default.
- W2061999024 hasPublicationYear "1991" @default.
- W2061999024 type Work @default.
- W2061999024 sameAs 2061999024 @default.
- W2061999024 citedByCount "4" @default.
- W2061999024 crossrefType "journal-article" @default.
- W2061999024 hasAuthorship W2061999024A5075762505 @default.
- W2061999024 hasAuthorship W2061999024A5079026280 @default.
- W2061999024 hasAuthorship W2061999024A5081269201 @default.
- W2061999024 hasAuthorship W2061999024A5087138716 @default.
- W2061999024 hasConcept C126322002 @default.
- W2061999024 hasConcept C134018914 @default.
- W2061999024 hasConcept C170493617 @default.
- W2061999024 hasConcept C184235292 @default.
- W2061999024 hasConcept C195794163 @default.
- W2061999024 hasConcept C24998067 @default.
- W2061999024 hasConcept C2777977426 @default.
- W2061999024 hasConcept C2778525890 @default.
- W2061999024 hasConcept C2778703144 @default.
- W2061999024 hasConcept C2779084600 @default.
- W2061999024 hasConcept C2908929049 @default.
- W2061999024 hasConcept C55493867 @default.
- W2061999024 hasConcept C71924100 @default.
- W2061999024 hasConcept C84393581 @default.
- W2061999024 hasConcept C86803240 @default.
- W2061999024 hasConcept C97029542 @default.
- W2061999024 hasConceptScore W2061999024C126322002 @default.
- W2061999024 hasConceptScore W2061999024C134018914 @default.
- W2061999024 hasConceptScore W2061999024C170493617 @default.
- W2061999024 hasConceptScore W2061999024C184235292 @default.
- W2061999024 hasConceptScore W2061999024C195794163 @default.
- W2061999024 hasConceptScore W2061999024C24998067 @default.
- W2061999024 hasConceptScore W2061999024C2777977426 @default.
- W2061999024 hasConceptScore W2061999024C2778525890 @default.
- W2061999024 hasConceptScore W2061999024C2778703144 @default.
- W2061999024 hasConceptScore W2061999024C2779084600 @default.
- W2061999024 hasConceptScore W2061999024C2908929049 @default.
- W2061999024 hasConceptScore W2061999024C55493867 @default.
- W2061999024 hasConceptScore W2061999024C71924100 @default.
- W2061999024 hasConceptScore W2061999024C84393581 @default.
- W2061999024 hasConceptScore W2061999024C86803240 @default.
- W2061999024 hasConceptScore W2061999024C97029542 @default.
- W2061999024 hasIssue "4" @default.
- W2061999024 hasLocation W20619990241 @default.
- W2061999024 hasLocation W20619990242 @default.
- W2061999024 hasOpenAccess W2061999024 @default.
- W2061999024 hasPrimaryLocation W20619990241 @default.
- W2061999024 hasRelatedWork W1966128948 @default.
- W2061999024 hasRelatedWork W1970273149 @default.
- W2061999024 hasRelatedWork W1974641745 @default.
- W2061999024 hasRelatedWork W1998134099 @default.
- W2061999024 hasRelatedWork W2009730237 @default.
- W2061999024 hasRelatedWork W2031833244 @default.
- W2061999024 hasRelatedWork W2054593959 @default.
- W2061999024 hasRelatedWork W2061999024 @default.
- W2061999024 hasRelatedWork W2116962665 @default.
- W2061999024 hasRelatedWork W2126797993 @default.
- W2061999024 hasVolume "38" @default.
- W2061999024 isParatext "false" @default.
- W2061999024 isRetracted "false" @default.
- W2061999024 magId "2061999024" @default.
- W2061999024 workType "article" @default.