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- W2062005474 abstract "In the last decade, we have witnessed numerous improvements and refinements in the diagnosis, staging and treatment of prostate cancer. However, an optimal management and therapeutical approach to this neoplasm is hampered by our relative inability to predict, with certainty, the exact pathological stage and aggressiveness of the neoplasm based on the results of biopsies only. Several authors have shown that there are sometimes large discrepancies between the Gleason score on the biopsy specimen and the definitive pathological report [1,2]. Djavan and co-workers showed, retrospectively reviewing the records of 415 patientswho underwent radical prostatectomy, that independent of the setting, about 50% of all Gleason scores assignments by needle biopsy specimenwere revised in the direction of a worse score category [1]. This is certainly very important for clinicians, when consulting with patients regarding treatment choices, if grade of disease has to be taken into consideration when proposing a therapy [2,3]. In this issue of EUROPEAN UROLOGY, Elabbady and co-workers show that, in their study, there was only a 50% agreement between the biopsy and the prostatectomy Gleason sum, with half of the cases being ‘undergraded’ by biopsies, if only sextant biopsies were taken. On the other hand, although the limitation of this study is the reduced number of cases, when a 12-core prostate biopsy core scheme was adopted, there was an agreement between the biopsy and the prostatectomy specimen in over 85%" @default.
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- W2062005474 date "2006-01-01" @default.
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- W2062005474 title "Prostate Cancer: Fine Tuning our Ability to Accurately Grade and Stage the Disease Prior to Therapy" @default.
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- W2062005474 doi "https://doi.org/10.1016/j.eururo.2005.10.018" @default.
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