FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062009351> ?p ?o ?g. }

• W2062009351 endingPage "108" @default.
• W2062009351 startingPage "97" @default.
• W2062009351 abstract "An antitumor activity associated with several bacterial pathogens, including Salmonella enterica serovar Typhimurium, has been reported; however, the underlying immunological mechanism(s) that lead to an antitumor effect are currently unclear. Furthermore, such pathogens cannot be used to suppress tumor growth because of their potential for causing sepsis. Recently, we reported the characterization of S. Typhimurium isogenic mutants from which Braun lipoprotein genes (lppA and B) and the multicopy repressor of high temperature requirement (msbB) gene were deleted. In a mouse infection model, two mutants, namely, lppB/msbB and lppAB/msbB, minimally induced proinflammatory cytokine production at high doses and were nonlethal to animals. We showed that immunization of mice with these mutants, followed by challenge with the wild-type S. Typhimurium, could significantly suppress tumor growth, as evidenced by an 88% regression in tumor size in lppB/msbB mutant-immunized animals over a 24-day period. However, the lppAB/msbB mutant alone was not effective in modulating tumor growth in mice, although the lppB/msbB mutant alone caused marginal regression in tumor size. Importantly, we showed that CD44+ cells grew much faster than CD44− cells from human liver tumors in mice, leading us to examine the possibility that S. Typhimurium might downregulate CD44 in tumors and splenocytes of mice. Consequently, we found in S. Typhimurium-infected mice that tumor size regression could indeed be related to the downregulation of CD44high and CD4+CD25+ Treg cells. Importantly, the role of lipopolysaccharide and Braun lipoprotein was critical in S. Typhimurium-induced antitumor immune responses. Taken together, we have defined new immune mechanisms leading to tumor suppression in mice by S. Typhimurium." @default.
• W2062009351 created "2016-06-24" @default.
• W2062009351 creator A5002454695 @default.
• W2062009351 creator A5018398198 @default.
• W2062009351 date "2009-08-28" @default.
• W2062009351 modified "2023-10-16" @default.
• W2062009351 title "An enteric pathogen Salmonella enterica serovar Typhimurium suppresses tumor growth by downregulating CD44high and CD4T regulatory (Treg) cell expression in mice: the critical role of lipopolysaccharide and Braun lipoprotein in modulating tumor growth" @default.
• W2062009351 cites W1483144827 @default.
• W2062009351 cites W1530044612 @default.
• W2062009351 cites W1595241211 @default.
• W2062009351 cites W1768580582 @default.
• W2062009351 cites W1829864197 @default.
• W2062009351 cites W1963832008 @default.
• W2062009351 cites W1968673060 @default.
• W2062009351 cites W1973880931 @default.
• W2062009351 cites W1976848291 @default.
• W2062009351 cites W1979565835 @default.
• W2062009351 cites W1983796940 @default.
• W2062009351 cites W1986884128 @default.
• W2062009351 cites W1991524518 @default.
• W2062009351 cites W2000547781 @default.
• W2062009351 cites W2014923037 @default.
• W2062009351 cites W2018075167 @default.
• W2062009351 cites W2018683219 @default.
• W2062009351 cites W2023427658 @default.
• W2062009351 cites W2029198863 @default.
• W2062009351 cites W2037307713 @default.
• W2062009351 cites W2037632318 @default.
• W2062009351 cites W2040544223 @default.
• W2062009351 cites W2041595086 @default.
• W2062009351 cites W2041858188 @default.
• W2062009351 cites W2045884854 @default.
• W2062009351 cites W2047376205 @default.
• W2062009351 cites W2058127285 @default.
• W2062009351 cites W2066307140 @default.
• W2062009351 cites W2067963142 @default.
• W2062009351 cites W2069290499 @default.
• W2062009351 cites W2069655066 @default.
• W2062009351 cites W2073310925 @default.
• W2062009351 cites W2076819781 @default.
• W2062009351 cites W2081226705 @default.
• W2062009351 cites W2081447858 @default.
• W2062009351 cites W2082634729 @default.
• W2062009351 cites W2084692958 @default.
• W2062009351 cites W2086445065 @default.
• W2062009351 cites W2091379575 @default.
• W2062009351 cites W2095884041 @default.
• W2062009351 cites W2097074641 @default.
• W2062009351 cites W2097388284 @default.
• W2062009351 cites W2103109433 @default.
• W2062009351 cites W2106175063 @default.
• W2062009351 cites W2113030185 @default.
• W2062009351 cites W2115632484 @default.
• W2062009351 cites W2116375075 @default.
• W2062009351 cites W2117427682 @default.
• W2062009351 cites W2122245635 @default.
• W2062009351 cites W2127999139 @default.
• W2062009351 cites W2132207502 @default.
• W2062009351 cites W2139151018 @default.
• W2062009351 cites W2145078103 @default.
• W2062009351 cites W2148911309 @default.
• W2062009351 cites W2153400272 @default.
• W2062009351 cites W2154787543 @default.
• W2062009351 cites W2155222839 @default.
• W2062009351 cites W2156149964 @default.
• W2062009351 cites W2169233545 @default.
• W2062009351 cites W2169706949 @default.
• W2062009351 cites W248355593 @default.
• W2062009351 cites W4242852378 @default.
• W2062009351 doi "https://doi.org/10.1038/cgt.2009.58" @default.
• W2062009351 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2808459" @default.
• W2062009351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19713997" @default.
• W2062009351 hasPublicationYear "2009" @default.
• W2062009351 type Work @default.
• W2062009351 sameAs 2062009351 @default.
• W2062009351 citedByCount "30" @default.
• W2062009351 countsByYear W20620093512012 @default.
• W2062009351 countsByYear W20620093512013 @default.
• W2062009351 countsByYear W20620093512014 @default.
• W2062009351 countsByYear W20620093512016 @default.
• W2062009351 countsByYear W20620093512017 @default.
• W2062009351 countsByYear W20620093512018 @default.
• W2062009351 countsByYear W20620093512019 @default.
• W2062009351 countsByYear W20620093512020 @default.
• W2062009351 countsByYear W20620093512021 @default.
• W2062009351 countsByYear W20620093512022 @default.
• W2062009351 countsByYear W20620093512023 @default.
• W2062009351 crossrefType "journal-article" @default.
• W2062009351 hasAuthorship W2062009351A5002454695 @default.
• W2062009351 hasAuthorship W2062009351A5018398198 @default.
• W2062009351 hasBestOaLocation W20620093511 @default.
• W2062009351 hasConcept C104317684 @default.
• W2062009351 hasConcept C127561419 @default.
• W2062009351 hasConcept C143065580 @default.
• W2062009351 hasConcept C144464004 @default.
• W2062009351 hasConcept C203014093 @default.
• W2062009351 hasConcept C2778754761 @default.
• W2062009351 hasConcept C2779607309 @default.

• next