Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062010039> ?p ?o ?g. }
- W2062010039 endingPage "497" @default.
- W2062010039 startingPage "489" @default.
- W2062010039 abstract "PD (Parkinson's disease) is a complex disorder that is associated with neuronal loss or dysfunction caused by genetic risks, environmental factors and advanced aging. It has been reported that DJ-1 mutations rendered neurons sensitive to oxidative damage, which led to the onset of familiar PD. However, the molecular mechanism is still unclear. In the present study we show that DJ-1 interacts with RACK1 (receptor of activated C kinase 1) and increases its dimerization and protein stability. The DJ-1 transgene protects cortical neurons from H2O2-induced apoptosis, and this protective effect is abrogated by knocking down RACK1. Similarly, deletion of DJ-1 in cortical neurons increases the sensitivity to H2O2, and the damage can be significantly rescued by DJ-1 or DJ-1/RACK1 co-transfection, but not by RACK1 alone. We observed further that the interaction of DJ-1 and RACK1 is disrupted by H2O2 or MPP+ (1-methyl-4-phenylpyridinium) treatment, and the protein levels of DJ-1 and RACK1 decreased in neurodegenerative disease models. Taken together, the DJ-1–RACK1 complex protects neurons from oxidative stress-induced apoptosis, with the implication that DJ-1 and RACK1 might be novel targets in the treatment of neurodegenerative diseases." @default.
- W2062010039 created "2016-06-24" @default.
- W2062010039 creator A5021058678 @default.
- W2062010039 creator A5022508036 @default.
- W2062010039 creator A5057207592 @default.
- W2062010039 creator A5059131186 @default.
- W2062010039 creator A5062324929 @default.
- W2062010039 creator A5072894305 @default.
- W2062010039 creator A5081491205 @default.
- W2062010039 creator A5088888083 @default.
- W2062010039 date "2014-08-22" @default.
- W2062010039 modified "2023-10-09" @default.
- W2062010039 title "DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis" @default.
- W2062010039 cites W1583407009 @default.
- W2062010039 cites W1877873625 @default.
- W2062010039 cites W1967603366 @default.
- W2062010039 cites W1968413329 @default.
- W2062010039 cites W1973046803 @default.
- W2062010039 cites W1973474734 @default.
- W2062010039 cites W1981550027 @default.
- W2062010039 cites W1982799599 @default.
- W2062010039 cites W1986464882 @default.
- W2062010039 cites W1987951773 @default.
- W2062010039 cites W1990847293 @default.
- W2062010039 cites W1993961540 @default.
- W2062010039 cites W1994715640 @default.
- W2062010039 cites W1995129249 @default.
- W2062010039 cites W2010177704 @default.
- W2062010039 cites W2014055529 @default.
- W2062010039 cites W2014837633 @default.
- W2062010039 cites W2020962370 @default.
- W2062010039 cites W2022802363 @default.
- W2062010039 cites W2026433745 @default.
- W2062010039 cites W2026841498 @default.
- W2062010039 cites W2026875466 @default.
- W2062010039 cites W2026982903 @default.
- W2062010039 cites W2033172620 @default.
- W2062010039 cites W2037079848 @default.
- W2062010039 cites W2041723344 @default.
- W2062010039 cites W2047195787 @default.
- W2062010039 cites W2054421268 @default.
- W2062010039 cites W2055905702 @default.
- W2062010039 cites W2059209321 @default.
- W2062010039 cites W2060947179 @default.
- W2062010039 cites W2072222440 @default.
- W2062010039 cites W2078209117 @default.
- W2062010039 cites W2078249788 @default.
- W2062010039 cites W2078312014 @default.
- W2062010039 cites W2084949662 @default.
- W2062010039 cites W2090906632 @default.
- W2062010039 cites W2095948536 @default.
- W2062010039 cites W2100962667 @default.
- W2062010039 cites W2102650364 @default.
- W2062010039 cites W2103551853 @default.
- W2062010039 cites W2104382960 @default.
- W2062010039 cites W2105631970 @default.
- W2062010039 cites W2105832396 @default.
- W2062010039 cites W2106695363 @default.
- W2062010039 cites W2111387452 @default.
- W2062010039 cites W2118864481 @default.
- W2062010039 cites W2120960347 @default.
- W2062010039 cites W2126760605 @default.
- W2062010039 cites W2133407217 @default.
- W2062010039 cites W2136347558 @default.
- W2062010039 cites W2145954079 @default.
- W2062010039 cites W2150634893 @default.
- W2062010039 cites W2150656456 @default.
- W2062010039 cites W2152626837 @default.
- W2062010039 cites W2158157853 @default.
- W2062010039 cites W2160572200 @default.
- W2062010039 cites W2163448221 @default.
- W2062010039 cites W2164738639 @default.
- W2062010039 cites W2166204330 @default.
- W2062010039 cites W2167054321 @default.
- W2062010039 cites W2167684435 @default.
- W2062010039 cites W2171595383 @default.
- W2062010039 cites W4255227753 @default.
- W2062010039 doi "https://doi.org/10.1042/bj20140235" @default.
- W2062010039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24947010" @default.
- W2062010039 hasPublicationYear "2014" @default.
- W2062010039 type Work @default.
- W2062010039 sameAs 2062010039 @default.
- W2062010039 citedByCount "26" @default.
- W2062010039 countsByYear W20620100392014 @default.
- W2062010039 countsByYear W20620100392015 @default.
- W2062010039 countsByYear W20620100392016 @default.
- W2062010039 countsByYear W20620100392017 @default.
- W2062010039 countsByYear W20620100392018 @default.
- W2062010039 countsByYear W20620100392019 @default.
- W2062010039 countsByYear W20620100392020 @default.
- W2062010039 countsByYear W20620100392021 @default.
- W2062010039 countsByYear W20620100392022 @default.
- W2062010039 countsByYear W20620100392023 @default.
- W2062010039 crossrefType "journal-article" @default.
- W2062010039 hasAuthorship W2062010039A5021058678 @default.
- W2062010039 hasAuthorship W2062010039A5022508036 @default.
- W2062010039 hasAuthorship W2062010039A5057207592 @default.
- W2062010039 hasAuthorship W2062010039A5059131186 @default.