FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062012115> ?p ?o ?g. }

• W2062012115 endingPage "1167" @default.
• W2062012115 startingPage "1161" @default.
• W2062012115 abstract "The aim of the present study was to investigate whether secretome obtained from normoxia-preconditioned human mesenchymal stem cells causes attenuation of traumatic brain injury (TBI), induced by fluid percussion injury.Anaesthetized male Sprague-Dawley rats, immediately after the onset of fluid percussion TBI, were divided into two major groups and given the vehicle solution (1 mL) or secretome (500 µg) intravenously. Another group of rats was used as sham-operated controls. The functional outcome such as motor (maximum grasp angle) was evaluated by an inclined plane test. Cellular infarction volume was calculated by triphenyltetrazolium chloride staining. Neuronal loss, apoptosis, and neurotrophic factor such as vascular epithelial growth factor (VEGF) expression in the cortex were measured by immunofluorescence staining. All the parameters were assessed on Day 3 after injury.Compared with those of the sham-operated controls, the motor deficits and cerebral infarction of rats after TBI were significantly attenuated by secretome therapy. The TBI-induced neuronal loss and apoptosis were also significantly reduced by secretome therapy. Furthermore, VEGF-positive cells in the ischemic cortex after TBI were further significantly increased by secretome therapy.Our results demonstrate that intravenous injection of secretome from normoxia-preconditioned human mesenchymal stem cells may ameliorate TBI-induced rats by reducing neuronal cell loss and apoptosis and promoting VEGF production, resulting in functional outcome improvement. We also recommend that secretome from normoxia-preconditioned human mesenchymal stem cells could be a promising treatment strategy for traumatic brain injury." @default.
• W2062012115 created "2016-06-24" @default.
• W2062012115 creator A5025329742 @default.
• W2062012115 creator A5033692984 @default.
• W2062012115 creator A5040304138 @default.
• W2062012115 creator A5058473995 @default.
• W2062012115 creator A5070517856 @default.
• W2062012115 creator A5091286358 @default.
• W2062012115 date "2012-11-01" @default.
• W2062012115 modified "2023-10-01" @default.
• W2062012115 title "Effects of secretome obtained from normoxia-preconditioned human mesenchymal stem cells in traumatic brain injury rats" @default.
• W2062012115 cites W1521417549 @default.
• W2062012115 cites W1971218073 @default.
• W2062012115 cites W1972461209 @default.
• W2062012115 cites W1975852594 @default.
• W2062012115 cites W1986298398 @default.
• W2062012115 cites W1991248271 @default.
• W2062012115 cites W1995316729 @default.
• W2062012115 cites W2008783846 @default.
• W2062012115 cites W2009532273 @default.
• W2062012115 cites W2013818100 @default.
• W2062012115 cites W2014386715 @default.
• W2062012115 cites W2018173450 @default.
• W2062012115 cites W2036452348 @default.
• W2062012115 cites W2043052859 @default.
• W2062012115 cites W2047455245 @default.
• W2062012115 cites W2051600991 @default.
• W2062012115 cites W2063784776 @default.
• W2062012115 cites W2065730275 @default.
• W2062012115 cites W2066954473 @default.
• W2062012115 cites W2068102253 @default.
• W2062012115 cites W2071115871 @default.
• W2062012115 cites W2077999133 @default.
• W2062012115 cites W2079424708 @default.
• W2062012115 cites W2080638375 @default.
• W2062012115 cites W2092885226 @default.
• W2062012115 cites W2095257528 @default.
• W2062012115 cites W2125325229 @default.
• W2062012115 cites W2131448844 @default.
• W2062012115 cites W2150892075 @default.
• W2062012115 cites W2153342452 @default.
• W2062012115 cites W2158496649 @default.
• W2062012115 cites W2163838709 @default.
• W2062012115 cites W2165421711 @default.
• W2062012115 cites W4254329016 @default.
• W2062012115 cites W4254868516 @default.
• W2062012115 doi "https://doi.org/10.1097/ta.0b013e318265d128" @default.
• W2062012115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22976425" @default.
• W2062012115 hasPublicationYear "2012" @default.
• W2062012115 type Work @default.
• W2062012115 sameAs 2062012115 @default.
• W2062012115 citedByCount "53" @default.
• W2062012115 countsByYear W20620121152013 @default.
• W2062012115 countsByYear W20620121152014 @default.
• W2062012115 countsByYear W20620121152015 @default.
• W2062012115 countsByYear W20620121152016 @default.
• W2062012115 countsByYear W20620121152017 @default.
• W2062012115 countsByYear W20620121152018 @default.
• W2062012115 countsByYear W20620121152019 @default.
• W2062012115 countsByYear W20620121152020 @default.
• W2062012115 countsByYear W20620121152021 @default.
• W2062012115 countsByYear W20620121152022 @default.
• W2062012115 countsByYear W20620121152023 @default.
• W2062012115 crossrefType "journal-article" @default.
• W2062012115 hasAuthorship W2062012115A5025329742 @default.
• W2062012115 hasAuthorship W2062012115A5033692984 @default.
• W2062012115 hasAuthorship W2062012115A5040304138 @default.
• W2062012115 hasAuthorship W2062012115A5058473995 @default.
• W2062012115 hasAuthorship W2062012115A5070517856 @default.
• W2062012115 hasAuthorship W2062012115A5091286358 @default.
• W2062012115 hasConcept C10882517 @default.
• W2062012115 hasConcept C118552586 @default.
• W2062012115 hasConcept C126322002 @default.
• W2062012115 hasConcept C142724271 @default.
• W2062012115 hasConcept C160539049 @default.
• W2062012115 hasConcept C170493617 @default.
• W2062012115 hasConcept C185592680 @default.
• W2062012115 hasConcept C190283241 @default.
• W2062012115 hasConcept C198826908 @default.
• W2062012115 hasConcept C2781017439 @default.
• W2062012115 hasConcept C28328180 @default.
• W2062012115 hasConcept C55493867 @default.
• W2062012115 hasConcept C71924100 @default.
• W2062012115 hasConcept C86803240 @default.
• W2062012115 hasConcept C95444343 @default.
• W2062012115 hasConceptScore W2062012115C10882517 @default.
• W2062012115 hasConceptScore W2062012115C118552586 @default.
• W2062012115 hasConceptScore W2062012115C126322002 @default.
• W2062012115 hasConceptScore W2062012115C142724271 @default.
• W2062012115 hasConceptScore W2062012115C160539049 @default.
• W2062012115 hasConceptScore W2062012115C170493617 @default.
• W2062012115 hasConceptScore W2062012115C185592680 @default.
• W2062012115 hasConceptScore W2062012115C190283241 @default.
• W2062012115 hasConceptScore W2062012115C198826908 @default.
• W2062012115 hasConceptScore W2062012115C2781017439 @default.
• W2062012115 hasConceptScore W2062012115C28328180 @default.
• W2062012115 hasConceptScore W2062012115C55493867 @default.
• W2062012115 hasConceptScore W2062012115C71924100 @default.

• next