Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062014008> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2062014008 endingPage "902" @default.
- W2062014008 startingPage "896" @default.
- W2062014008 abstract "Aim: This study investigated the mechanisms involved in intrauterine growth restriction (IUGR). Methods: The IUGR model was established by feeding pregnant SD rats a low-protein diet. Protein expression and phosphorylation were detected using Western blot and/or immunohistochemistry. Cell apoptosis was detected by TUNEL staining. The MDM2 mRNA expression was measured by real-time PCR. Results: Pups from the IUGR group had significantly lower body (7th day, 2 months) and kidney weights (1st day, 7th day, 2 months) compared to pups from the control group (p < 0.01). The glomeruli number in IUGR pups was significantly less than that in the control pups at 2 and 3 months after birth (p < 0.01). p53 protein level and p53 phosphorylation at Ser15 were time-dependently decreased in the kidney at 1st day, 7th day, 21st day, 2 months and 3 months, but their levels in the kidney of the IUGR pups was significantly higher than that in control pups at each time point (p < 0.05, p < 0.01, or p < 0.001). Significantly more positive p21 staining was observed in IUGR pups than in control pups at each time point. Real-time PCR of MDM2 mRNA expression showed no significant difference between IUGR and control pups (p > 0.05). Significant apoptosis was observed in the kidneys of IUGR pups compared to control pups. Conclusion: Malnutrition-induced IUGR may be associated with the activation of p53–p21 signaling in the kidney." @default.
- W2062014008 created "2016-06-24" @default.
- W2062014008 creator A5005503474 @default.
- W2062014008 creator A5025749942 @default.
- W2062014008 creator A5037674582 @default.
- W2062014008 creator A5063759157 @default.
- W2062014008 creator A5084674975 @default.
- W2062014008 creator A5087422594 @default.
- W2062014008 date "2015-02-27" @default.
- W2062014008 modified "2023-10-16" @default.
- W2062014008 title "Dynamic p53 protein expression and phosphorylation in the kidneys of rats that experienced intrauterine growth restriction" @default.
- W2062014008 cites W1963842005 @default.
- W2062014008 cites W1972339030 @default.
- W2062014008 cites W2001533493 @default.
- W2062014008 cites W2004193166 @default.
- W2062014008 cites W2014658492 @default.
- W2062014008 cites W2039543436 @default.
- W2062014008 cites W2045573741 @default.
- W2062014008 cites W2068902860 @default.
- W2062014008 cites W2074467897 @default.
- W2062014008 cites W2074622102 @default.
- W2062014008 cites W2087664337 @default.
- W2062014008 cites W2094826025 @default.
- W2062014008 cites W2136906761 @default.
- W2062014008 cites W2139020475 @default.
- W2062014008 cites W2148189411 @default.
- W2062014008 cites W2160252164 @default.
- W2062014008 cites W2162910153 @default.
- W2062014008 doi "https://doi.org/10.3109/0886022x.2015.1015428" @default.
- W2062014008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25721428" @default.
- W2062014008 hasPublicationYear "2015" @default.
- W2062014008 type Work @default.
- W2062014008 sameAs 2062014008 @default.
- W2062014008 citedByCount "6" @default.
- W2062014008 countsByYear W20620140082017 @default.
- W2062014008 countsByYear W20620140082020 @default.
- W2062014008 countsByYear W20620140082021 @default.
- W2062014008 crossrefType "journal-article" @default.
- W2062014008 hasAuthorship W2062014008A5005503474 @default.
- W2062014008 hasAuthorship W2062014008A5025749942 @default.
- W2062014008 hasAuthorship W2062014008A5037674582 @default.
- W2062014008 hasAuthorship W2062014008A5063759157 @default.
- W2062014008 hasAuthorship W2062014008A5084674975 @default.
- W2062014008 hasAuthorship W2062014008A5087422594 @default.
- W2062014008 hasConcept C104317684 @default.
- W2062014008 hasConcept C105580179 @default.
- W2062014008 hasConcept C126322002 @default.
- W2062014008 hasConcept C134018914 @default.
- W2062014008 hasConcept C16685009 @default.
- W2062014008 hasConcept C172680121 @default.
- W2062014008 hasConcept C190283241 @default.
- W2062014008 hasConcept C196795494 @default.
- W2062014008 hasConcept C204232928 @default.
- W2062014008 hasConcept C2776415932 @default.
- W2062014008 hasConcept C2778780700 @default.
- W2062014008 hasConcept C2779234561 @default.
- W2062014008 hasConcept C2780091579 @default.
- W2062014008 hasConcept C54355233 @default.
- W2062014008 hasConcept C55493867 @default.
- W2062014008 hasConcept C71924100 @default.
- W2062014008 hasConcept C86803240 @default.
- W2062014008 hasConceptScore W2062014008C104317684 @default.
- W2062014008 hasConceptScore W2062014008C105580179 @default.
- W2062014008 hasConceptScore W2062014008C126322002 @default.
- W2062014008 hasConceptScore W2062014008C134018914 @default.
- W2062014008 hasConceptScore W2062014008C16685009 @default.
- W2062014008 hasConceptScore W2062014008C172680121 @default.
- W2062014008 hasConceptScore W2062014008C190283241 @default.
- W2062014008 hasConceptScore W2062014008C196795494 @default.
- W2062014008 hasConceptScore W2062014008C204232928 @default.
- W2062014008 hasConceptScore W2062014008C2776415932 @default.
- W2062014008 hasConceptScore W2062014008C2778780700 @default.
- W2062014008 hasConceptScore W2062014008C2779234561 @default.
- W2062014008 hasConceptScore W2062014008C2780091579 @default.
- W2062014008 hasConceptScore W2062014008C54355233 @default.
- W2062014008 hasConceptScore W2062014008C55493867 @default.
- W2062014008 hasConceptScore W2062014008C71924100 @default.
- W2062014008 hasConceptScore W2062014008C86803240 @default.
- W2062014008 hasIssue "5" @default.
- W2062014008 hasLocation W20620140081 @default.
- W2062014008 hasLocation W20620140082 @default.
- W2062014008 hasOpenAccess W2062014008 @default.
- W2062014008 hasPrimaryLocation W20620140081 @default.
- W2062014008 hasRelatedWork W1492562710 @default.
- W2062014008 hasRelatedWork W1553598265 @default.
- W2062014008 hasRelatedWork W1972755053 @default.
- W2062014008 hasRelatedWork W2042033030 @default.
- W2062014008 hasRelatedWork W2044943066 @default.
- W2062014008 hasRelatedWork W2127085070 @default.
- W2062014008 hasRelatedWork W2368731425 @default.
- W2062014008 hasRelatedWork W2380423849 @default.
- W2062014008 hasRelatedWork W2389467880 @default.
- W2062014008 hasRelatedWork W2409970655 @default.
- W2062014008 hasVolume "37" @default.
- W2062014008 isParatext "false" @default.
- W2062014008 isRetracted "false" @default.
- W2062014008 magId "2062014008" @default.
- W2062014008 workType "article" @default.