FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062014401> ?p ?o ?g. }

• W2062014401 endingPage "e89" @default.
• W2062014401 startingPage "e89" @default.
• W2062014401 abstract "Genes with common functions often exhibit correlated expression levels, which can be used to identify sets of interacting genes from microarray data. Microarrays typically measure expression across genomic space, creating a massive matrix of co-expression that must be mined to extract only the most relevant gene interactions. We describe a graph theoretical approach to extracting co-expressed sets of genes, based on the computation of cliques. Unlike the results of traditional clustering algorithms, cliques are not disjoint and allow genes to be assigned to multiple sets of interacting partners, consistent with biological reality. A graph is created by thresholding the correlation matrix to include only the correlations most likely to signify functional relationships. Cliques computed from the graph correspond to sets of genes for which significant edges are present between all members of the set, representing potential members of common or interacting pathways. Clique membership can be used to infer function about poorly annotated genes, based on the known functions of better-annotated genes with which they share clique membership (i.e., guilt-by-association). We illustrate our method by applying it to microarray data collected from the spleens of mice exposed to low-dose ionizing radiation. Differential analysis is used to identify sets of genes whose interactions are impacted by radiation exposure. The correlation graph is also queried independently of clique to extract edges that are impacted by radiation. We present several examples of multiple gene interactions that are altered by radiation exposure and thus represent potential molecular pathways that mediate the radiation response." @default.
• W2062014401 created "2016-06-24" @default.
• W2062014401 creator A5004037069 @default.
• W2062014401 creator A5005914571 @default.
• W2062014401 creator A5007918640 @default.
• W2062014401 creator A5011863644 @default.
• W2062014401 creator A5022843316 @default.
• W2062014401 creator A5041646784 @default.
• W2062014401 creator A5078289125 @default.
• W2062014401 creator A5083172043 @default.
• W2062014401 date "2006-07-21" @default.
• W2062014401 modified "2023-09-29" @default.
• W2062014401 title "Extracting Gene Networks for Low-Dose Radiation Using Graph Theoretical Algorithms" @default.
• W2062014401 cites W1494144074 @default.
• W2062014401 cites W1496377586 @default.
• W2062014401 cites W1530803355 @default.
• W2062014401 cites W1637197683 @default.
• W2062014401 cites W1937631396 @default.
• W2062014401 cites W1977126501 @default.
• W2062014401 cites W1983773767 @default.
• W2062014401 cites W1987678450 @default.
• W2062014401 cites W1988648841 @default.
• W2062014401 cites W1990899950 @default.
• W2062014401 cites W2002810210 @default.
• W2062014401 cites W2003371280 @default.
• W2062014401 cites W2008620264 @default.
• W2062014401 cites W2009099877 @default.
• W2062014401 cites W2009479752 @default.
• W2062014401 cites W2011932089 @default.
• W2062014401 cites W2013444425 @default.
• W2062014401 cites W2020681752 @default.
• W2062014401 cites W2021129827 @default.
• W2062014401 cites W2027549508 @default.
• W2062014401 cites W2029860961 @default.
• W2062014401 cites W2034784092 @default.
• W2062014401 cites W2041779532 @default.
• W2062014401 cites W2043344835 @default.
• W2062014401 cites W2048316945 @default.
• W2062014401 cites W2054616845 @default.
• W2062014401 cites W2055708024 @default.
• W2062014401 cites W2060140771 @default.
• W2062014401 cites W2070723308 @default.
• W2062014401 cites W2072184218 @default.
• W2062014401 cites W2081280838 @default.
• W2062014401 cites W2082603400 @default.
• W2062014401 cites W2087609307 @default.
• W2062014401 cites W2092608508 @default.
• W2062014401 cites W2095795258 @default.
• W2062014401 cites W2096373458 @default.
• W2062014401 cites W2096768449 @default.
• W2062014401 cites W2097545237 @default.
• W2062014401 cites W2099388441 @default.
• W2062014401 cites W2103644749 @default.
• W2062014401 cites W2108334325 @default.
• W2062014401 cites W2115370041 @default.
• W2062014401 cites W211697509 @default.
• W2062014401 cites W2118769864 @default.
• W2062014401 cites W2118852675 @default.
• W2062014401 cites W2123106337 @default.
• W2062014401 cites W2127938920 @default.
• W2062014401 cites W2138790773 @default.
• W2062014401 cites W2139651996 @default.
• W2062014401 cites W2146264532 @default.
• W2062014401 cites W2150926065 @default.
• W2062014401 cites W2154437541 @default.
• W2062014401 cites W2159767718 @default.
• W2062014401 cites W2162142896 @default.
• W2062014401 cites W2163480486 @default.
• W2062014401 cites W2170875374 @default.
• W2062014401 cites W2171070506 @default.
• W2062014401 cites W2326160172 @default.
• W2062014401 cites W2475962691 @default.
• W2062014401 cites W3103786587 @default.
• W2062014401 cites W4292230561 @default.
• W2062014401 doi "https://doi.org/10.1371/journal.pcbi.0020089" @default.
• W2062014401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1513268" @default.
• W2062014401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16854212" @default.
• W2062014401 hasPublicationYear "2006" @default.
• W2062014401 type Work @default.
• W2062014401 sameAs 2062014401 @default.
• W2062014401 citedByCount "100" @default.
• W2062014401 countsByYear W20620144012012 @default.
• W2062014401 countsByYear W20620144012013 @default.
• W2062014401 countsByYear W20620144012014 @default.
• W2062014401 countsByYear W20620144012015 @default.
• W2062014401 countsByYear W20620144012016 @default.
• W2062014401 countsByYear W20620144012017 @default.
• W2062014401 countsByYear W20620144012018 @default.
• W2062014401 countsByYear W20620144012019 @default.
• W2062014401 countsByYear W20620144012020 @default.
• W2062014401 countsByYear W20620144012021 @default.
• W2062014401 countsByYear W20620144012022 @default.
• W2062014401 countsByYear W20620144012023 @default.
• W2062014401 crossrefType "journal-article" @default.
• W2062014401 hasAuthorship W2062014401A5004037069 @default.
• W2062014401 hasAuthorship W2062014401A5005914571 @default.
• W2062014401 hasAuthorship W2062014401A5007918640 @default.
• W2062014401 hasAuthorship W2062014401A5011863644 @default.

• next