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- W2062022668 abstract "The effects of the addition of recombinant interleukin (IL)-12 to a mycobacterial subunit vaccine were analyzed in terms of the longevity of the protective immunity generated. BALB/c mice were immunized with culture filtrate proteins from Mycobacterium avium with dimethyl-dioctadecilammonium bromide (DDA) as an adjuvant. This subunit vaccine induced protection against a challenge by M. avium which lasted for at least 6 months while waning with time until 1 year postvaccination. Whereas the addition of IL-12 enhanced the initial protective efficacy of this subunit vaccine during the first 6 months, it accelerated the loss of protective efficacy observed at 1 year postvaccination. These data confirm the adjuvant properties of IL-12 in vaccines against mycobacteria and raise the possibility of late counter-protective untoward effects." @default.
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- W2062022668 date "2000-12-01" @default.
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- W2062022668 title "Effects of Interleukin-12 in the Long-term Protection Conferred by a Mycobacterium avium Subunit Vaccine . FRONTLINES" @default.
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- W2062022668 doi "https://doi.org/10.1046/j.1365-3083.2000.00816.x" @default.
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