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• W2062028802 abstract "Type 1 diabetes mellitus is caused by the T cell mediated autoimmune destruction of insulin-producing beta cells of the islets of Langerhans within the pancreas. Current immunotherapy strategies are aimed at directly inactivating the autoreactive T cells and/or inducing T cells with regulatory capabilities. At the preclinical level, several strategies that employ TCR antagonists -- including monoclonal antibodies, autoantigen-specific peptides and soluble TCR ligands -- are showing promise and being developed for clinical application. Several of these approaches employing monoclonal antibodies against the TCR-CD3 complex or soluble peptide antigens are producing favorable results in the clinic." @default.
• W2062028802 created "2016-06-24" @default.
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• W2062028802 creator A5028331971 @default.
• W2062028802 date "2002-10-01" @default.
• W2062028802 modified "2023-10-17" @default.
• W2062028802 title "Immunotherapy of insulin-dependent diabetes mellitus" @default.
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• W2062028802 doi "https://doi.org/10.1016/s0952-7915(02)00375-8" @default.
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