FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062031200> ?p ?o ?g. }

• W2062031200 endingPage "160" @default.
• W2062031200 startingPage "152" @default.
• W2062031200 abstract "Several classes of antifungal have been employed in candidiasis treatment, but patients with advanced immunodeficiency can present unsatisfactory results after therapy. In these cases, high doses of drugs or the use of multiple agents are sometimes used, and hence increasing the risk of serious side effects. Considering theses difficulties, the encapsulation of antifungal agents in nanoparticulate carriers has been used with the objective of modifying the pharmacokinetic of drugs resulting in more efficient treatments with less side effects. The purpose of this work was the preparation, characterization and the investigation of the release profiles of radiolabeled fluconazole nanocapsules. The size, homogeneity and zeta potential of NC preparations were determined with a Zetasizer 3000HS. The morphology and the structural organization were evaluated by atomic force microscopy (AFM). The release study in vitro of NC was evaluated in physiologic solution with or without 70% mouse plasma. The labeling yield of fluconazole with 99mTc was 94% and the radiolabeled drug was stable within 24 h period. The encapsulation percentage of 99mTc-fluconazole in PLA-POLOX NC and PLA-PEG NC was approximately of 30%. The average diameter calculated by photon correlation spectroscopy (PCS) varied from 236 to 356 nm, while the average diameter determined by AFM varied from 238 to 411 nm. The diameter/height relation decreased significantly when 25% glutaraldehyde was used for NC fixation on mica. The zeta potential varied from −55 to −69 nm and surface-modified NC showed lower absolute values than conventional NC. The in vitro release of 99mTc-fluconazole in plasma medium of the conventional and surface-modified NC was greater than in saline. The drug release in plasma medium from conventional NC was faster than for surface-modified NC. The results obtained in this work suggest that the nanocapsules containing fluconazole could be used to identify infectious foci, due to the properties, such as size, zeta potential and controlled release of 99mTc-fluconazole. The surface-modified nanocapsules could constitute a long-circulating intravenous formulation of fluconazole for treating sepsis caused by disseminated form of candidiasis. However, in vivo studies should be considered and are under investigation." @default.
• W2062031200 created "2016-06-24" @default.
• W2062031200 creator A5017997442 @default.
• W2062031200 creator A5045184993 @default.
• W2062031200 creator A5051909859 @default.
• W2062031200 creator A5063528242 @default.
• W2062031200 creator A5088228106 @default.
• W2062031200 date "2008-02-12" @default.
• W2062031200 modified "2023-10-01" @default.
• W2062031200 title "Release profiles and morphological characterization by atomic force microscopy and photon correlation spectroscopy of 99mTechnetium-fluconazole nanocapsules" @default.
• W2062031200 cites W1964095798 @default.
• W2062031200 cites W1966028600 @default.
• W2062031200 cites W1966940765 @default.
• W2062031200 cites W1966963585 @default.
• W2062031200 cites W1971180782 @default.
• W2062031200 cites W1974084223 @default.
• W2062031200 cites W1974210203 @default.
• W2062031200 cites W1976613720 @default.
• W2062031200 cites W1977571447 @default.
• W2062031200 cites W1988672795 @default.
• W2062031200 cites W1995977601 @default.
• W2062031200 cites W2029749273 @default.
• W2062031200 cites W2040472996 @default.
• W2062031200 cites W2044958437 @default.
• W2062031200 cites W204512410 @default.
• W2062031200 cites W2067424452 @default.
• W2062031200 cites W2081059643 @default.
• W2062031200 cites W2086716483 @default.
• W2062031200 cites W2094087997 @default.
• W2062031200 cites W2101312385 @default.
• W2062031200 cites W2109738703 @default.
• W2062031200 cites W2123624166 @default.
• W2062031200 cites W2127412756 @default.
• W2062031200 cites W2131041162 @default.
• W2062031200 cites W2139730382 @default.
• W2062031200 cites W2144907950 @default.
• W2062031200 cites W2146237608 @default.
• W2062031200 cites W2164270244 @default.
• W2062031200 cites W2166712052 @default.
• W2062031200 cites W2312211583 @default.
• W2062031200 cites W2465037386 @default.
• W2062031200 cites W2481444774 @default.
• W2062031200 cites W2508313043 @default.
• W2062031200 doi "https://doi.org/10.1016/j.ijpharm.2007.08.002" @default.
• W2062031200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17869460" @default.
• W2062031200 hasPublicationYear "2008" @default.
• W2062031200 type Work @default.
• W2062031200 sameAs 2062031200 @default.
• W2062031200 citedByCount "79" @default.
• W2062031200 countsByYear W20620312002012 @default.
• W2062031200 countsByYear W20620312002013 @default.
• W2062031200 countsByYear W20620312002014 @default.
• W2062031200 countsByYear W20620312002015 @default.
• W2062031200 countsByYear W20620312002016 @default.
• W2062031200 countsByYear W20620312002017 @default.
• W2062031200 countsByYear W20620312002018 @default.
• W2062031200 countsByYear W20620312002019 @default.
• W2062031200 countsByYear W20620312002020 @default.
• W2062031200 countsByYear W20620312002021 @default.
• W2062031200 countsByYear W20620312002022 @default.
• W2062031200 countsByYear W20620312002023 @default.
• W2062031200 crossrefType "journal-article" @default.
• W2062031200 hasAuthorship W2062031200A5017997442 @default.
• W2062031200 hasAuthorship W2062031200A5045184993 @default.
• W2062031200 hasAuthorship W2062031200A5051909859 @default.
• W2062031200 hasAuthorship W2062031200A5063528242 @default.
• W2062031200 hasAuthorship W2062031200A5088228106 @default.
• W2062031200 hasBestOaLocation W20620312002 @default.
• W2062031200 hasConcept C10138342 @default.
• W2062031200 hasConcept C102951782 @default.
• W2062031200 hasConcept C155672457 @default.
• W2062031200 hasConcept C16005928 @default.
• W2062031200 hasConcept C162324750 @default.
• W2062031200 hasConcept C171250308 @default.
• W2062031200 hasConcept C185592680 @default.
• W2062031200 hasConcept C192562407 @default.
• W2062031200 hasConcept C204399865 @default.
• W2062031200 hasConcept C2777529624 @default.
• W2062031200 hasConcept C2779548794 @default.
• W2062031200 hasConcept C2780651595 @default.
• W2062031200 hasConcept C43617362 @default.
• W2062031200 hasConcept C54400483 @default.
• W2062031200 hasConcept C71924100 @default.
• W2062031200 hasConcept C86181022 @default.
• W2062031200 hasConceptScore W2062031200C10138342 @default.
• W2062031200 hasConceptScore W2062031200C102951782 @default.
• W2062031200 hasConceptScore W2062031200C155672457 @default.
• W2062031200 hasConceptScore W2062031200C16005928 @default.
• W2062031200 hasConceptScore W2062031200C162324750 @default.
• W2062031200 hasConceptScore W2062031200C171250308 @default.
• W2062031200 hasConceptScore W2062031200C185592680 @default.
• W2062031200 hasConceptScore W2062031200C192562407 @default.
• W2062031200 hasConceptScore W2062031200C204399865 @default.
• W2062031200 hasConceptScore W2062031200C2777529624 @default.
• W2062031200 hasConceptScore W2062031200C2779548794 @default.
• W2062031200 hasConceptScore W2062031200C2780651595 @default.
• W2062031200 hasConceptScore W2062031200C43617362 @default.
• W2062031200 hasConceptScore W2062031200C54400483 @default.

• next