Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062034190> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2062034190 endingPage "E829" @default.
- W2062034190 startingPage "E822" @default.
- W2062034190 abstract "Plasma glucose, insulin, and C-peptide responses during an OGTT are informative for both research and clinical practice in type 2 diabetes. The aim of this study was to use such information to determine insulin sensitivity and insulin secretion so as to calculate an oral glucose disposition index (DI OGTT ) that is a measure of pancreatic β-cell insulin secretory compensation for changing insulin sensitivity. We conducted an observational study of n = 187 subjects, representing the entire glucose tolerance continuum from normal glucose tolerance to type 2 diabetes. OGTT-derived insulin sensitivity (S I OGTT ) was calculated using a novel multiple-regression model derived from insulin sensitivity measured by hyperinsulinemic euglycemic clamp as the independent variable. We also validated the novel S I OGTT in n = 40 subjects from an independent data set. Plasma C-peptide responses during OGTT were used to determine oral glucose-stimulated insulin secretion (GSIS OGTT ), and DI OGTT was calculated as the product of S I OGTT and GSIS OGTT . Our novel S I OGTT showed high agreement with clamp-derived insulin sensitivity (typical error = +3.6%; r = 0.69, P < 0.0001) and that insulin sensitivity was lowest in subjects with impaired glucose tolerance and type 2 diabetes. GSIS OGTT demonstrated a significant inverse relationship with S I OGTT . GSIS OGTT was lowest in normal glucose-tolerant subjects and greatest in those with impaired glucose tolerance. DI OGTT was sequentially lower with advancing glucose intolerance. We hereby derive and validate a novel OGTT-derived measurement of insulin sensitivity across the entire glucose tolerance continuum and demonstrate that β-cell compensation for changing insulin sensitivity can be readily calculated from clinical variables collected during OGTT." @default.
- W2062034190 created "2016-06-24" @default.
- W2062034190 creator A5012592007 @default.
- W2062034190 creator A5014871972 @default.
- W2062034190 creator A5015937337 @default.
- W2062034190 creator A5026644774 @default.
- W2062034190 creator A5040290418 @default.
- W2062034190 creator A5051857476 @default.
- W2062034190 creator A5059817069 @default.
- W2062034190 creator A5060815860 @default.
- W2062034190 creator A5087832292 @default.
- W2062034190 date "2014-11-01" @default.
- W2062034190 modified "2023-10-14" @default.
- W2062034190 title "Determining pancreatic β-cell compensation for changing insulin sensitivity using an oral glucose tolerance test" @default.
- W2062034190 cites W1982111510 @default.
- W2062034190 cites W2023300718 @default.
- W2062034190 cites W2023663637 @default.
- W2062034190 cites W2061309116 @default.
- W2062034190 cites W2117233341 @default.
- W2062034190 cites W2119878811 @default.
- W2062034190 cites W2124232607 @default.
- W2062034190 cites W2132399664 @default.
- W2062034190 cites W2132806782 @default.
- W2062034190 cites W2133795831 @default.
- W2062034190 cites W2152956628 @default.
- W2062034190 cites W2165252181 @default.
- W2062034190 cites W2170932033 @default.
- W2062034190 cites W2189221254 @default.
- W2062034190 doi "https://doi.org/10.1152/ajpendo.00269.2014" @default.
- W2062034190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4216951" @default.
- W2062034190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25184989" @default.
- W2062034190 hasPublicationYear "2014" @default.
- W2062034190 type Work @default.
- W2062034190 sameAs 2062034190 @default.
- W2062034190 citedByCount "21" @default.
- W2062034190 countsByYear W20620341902015 @default.
- W2062034190 countsByYear W20620341902016 @default.
- W2062034190 countsByYear W20620341902017 @default.
- W2062034190 countsByYear W20620341902018 @default.
- W2062034190 countsByYear W20620341902019 @default.
- W2062034190 countsByYear W20620341902020 @default.
- W2062034190 countsByYear W20620341902021 @default.
- W2062034190 countsByYear W20620341902022 @default.
- W2062034190 countsByYear W20620341902023 @default.
- W2062034190 crossrefType "journal-article" @default.
- W2062034190 hasAuthorship W2062034190A5012592007 @default.
- W2062034190 hasAuthorship W2062034190A5014871972 @default.
- W2062034190 hasAuthorship W2062034190A5015937337 @default.
- W2062034190 hasAuthorship W2062034190A5026644774 @default.
- W2062034190 hasAuthorship W2062034190A5040290418 @default.
- W2062034190 hasAuthorship W2062034190A5051857476 @default.
- W2062034190 hasAuthorship W2062034190A5059817069 @default.
- W2062034190 hasAuthorship W2062034190A5060815860 @default.
- W2062034190 hasAuthorship W2062034190A5087832292 @default.
- W2062034190 hasBestOaLocation W20620341902 @default.
- W2062034190 hasConcept C126322002 @default.
- W2062034190 hasConcept C134018914 @default.
- W2062034190 hasConcept C2777180221 @default.
- W2062034190 hasConcept C2777391703 @default.
- W2062034190 hasConcept C2779306644 @default.
- W2062034190 hasConcept C2780609358 @default.
- W2062034190 hasConcept C2780833929 @default.
- W2062034190 hasConcept C3017594256 @default.
- W2062034190 hasConcept C555293320 @default.
- W2062034190 hasConcept C71924100 @default.
- W2062034190 hasConceptScore W2062034190C126322002 @default.
- W2062034190 hasConceptScore W2062034190C134018914 @default.
- W2062034190 hasConceptScore W2062034190C2777180221 @default.
- W2062034190 hasConceptScore W2062034190C2777391703 @default.
- W2062034190 hasConceptScore W2062034190C2779306644 @default.
- W2062034190 hasConceptScore W2062034190C2780609358 @default.
- W2062034190 hasConceptScore W2062034190C2780833929 @default.
- W2062034190 hasConceptScore W2062034190C3017594256 @default.
- W2062034190 hasConceptScore W2062034190C555293320 @default.
- W2062034190 hasConceptScore W2062034190C71924100 @default.
- W2062034190 hasIssue "9" @default.
- W2062034190 hasLocation W20620341901 @default.
- W2062034190 hasLocation W20620341902 @default.
- W2062034190 hasLocation W20620341903 @default.
- W2062034190 hasLocation W20620341904 @default.
- W2062034190 hasOpenAccess W2062034190 @default.
- W2062034190 hasPrimaryLocation W20620341901 @default.
- W2062034190 hasRelatedWork W138803513 @default.
- W2062034190 hasRelatedWork W1986132654 @default.
- W2062034190 hasRelatedWork W1992838000 @default.
- W2062034190 hasRelatedWork W2004880720 @default.
- W2062034190 hasRelatedWork W2010140898 @default.
- W2062034190 hasRelatedWork W2026316039 @default.
- W2062034190 hasRelatedWork W2028627743 @default.
- W2062034190 hasRelatedWork W2082140668 @default.
- W2062034190 hasRelatedWork W2430205611 @default.
- W2062034190 hasRelatedWork W4234612679 @default.
- W2062034190 hasVolume "307" @default.
- W2062034190 isParatext "false" @default.
- W2062034190 isRetracted "false" @default.
- W2062034190 magId "2062034190" @default.
- W2062034190 workType "article" @default.