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- W206204218 abstract "Tb determine, using meta-analysis, the benefits and harms of antibiotic use in children with acute otitis media (AOM). Data sources Studies were identified using Index Mediats (1958 to 1965), MEDLINE, and Cwrent Contents (1966 to 1994) with the term otitis media and methodological search terms for identifying controlled trials. Bibliographies of retrieved studies were also reviewed. Study selection Studies were selected if they were randomised controlled trials of antimicrobial drugs compared with placebo for treatment of AOM. Data extraction Data were extracted on severity and duration of pain, deafness, recurrent attacks, and adverse effects. A quality score was assigned to each study on the basis of its methods, which included treatment assignment, control of selection bias, adequacy of blinding, and objective assessment of outcome. Quality was assessed independently by 3 investigators. Main results 7 studies (1984 patients, age range 7 mo to 15 y) were included in the analysis. Compared with placebo, antibiotic treatment did not reduce pain at 24 hours {P= 0.94}* but did at 2 to 7 days after presentation {P < 0.001}* (Table). Antibiotics also reduced the incidence of contralateral AOM {P= 0.002}* and of deafness at 3 months {P = 0.035}* (Table). Antibiotics did not reduce the incidence of recurrent otitis media [P = 0.91}* and were associated with increased adverse effects, including vomiting, diarrhoea, and rashes (odds ratio 1.97, 95% CI 1.19 to 3.25). Conclusions In children with acute otitis media, the use of antibiotics decreases pain at 2 to 7 days after presentation and reduces contralateral acute otitis media and deafness at 3 months. Antibiotics do not reduce pain within 24 hours or prevent recurrent otitis media." @default.
- W206204218 created "2016-06-24" @default.
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- W206204218 date "1998-01-01" @default.
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- W206204218 title "Review: Antibiotics provide modest benefit for acute otitis media" @default.
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