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- W2062052826 abstract "We have studied the division of postembryonic neuroblasts (Nbs) in the outer proliferation center (OPC) and central brain anlagen of Drosophila. We focused our attention on three aspects of these processes: the pattern of cellular division, the topological orientation of those divisions, and the expression of asymmetric cell fate determinants. Although larval Nbs are of embryonic origin, our results indicate that their properties appear to be modified during development. Several conclusions can be summarized: (i) In early larvae, Nbs divide symmetrically to give rise to two Nbs while in the late larval brain most Nbs divide asymmetrically to bud off an intermediate ganglion mother cell (GMC) that very rapidly divides into two ganglion cells (GC). (ii) Symmetric and asymmetric divisions of OPC Nbs show tangential and radial orientations, respectively. (iii) This change in the pattern of division correlates with the expression of inscuteable, which is apically localized only in asymmetric divisions. (iv) The spindle of asymmetrically dividing Nb is always oriented on an apical-basal axis. (v) Prospero does not colocalize with Miranda in the cortical crescent of mitotic Nbs. (vi) Prospero is transiently expressed in one of the two sibling GCs generated by the division of GMCs. The implications of these results on cell fate specification and differentiation of adult brain neurons are discussed." @default.
- W2062052826 created "2016-06-24" @default.
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- W2062052826 creator A5061976846 @default.
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- W2062052826 date "2001-02-01" @default.
- W2062052826 modified "2023-09-29" @default.
- W2062052826 title "Patterns of Cell Division and Expression of Asymmetric Cell Fate Determinants in Postembryonic Neuroblast Lineages of Drosophila" @default.
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- W2062052826 doi "https://doi.org/10.1006/dbio.2000.0110" @default.
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