Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062054260> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2062054260 endingPage "216" @default.
- W2062054260 startingPage "212" @default.
- W2062054260 abstract "Matrix metallproteinases (MMP)-2 and -9 are associated with cancer invasion and metastasis. MMP-2 and MMP-9 activities have never been assayed in bile. In the present study we investigated whether MMP-2 and -9 activities in the bile could be a marker for evaluation of liver metastasis in colorectal cancer. Fifty-three patients underwent colorectal resection for histologically verified adenocarcinoma. Twenty-six patients had colorectal cancer without liver metastasis and 27 patients had metastatic liver tumor. Six patients were studied as carcinoma-free control. MMP-2 and MMP-9 activities were assayed in bile using gelatin zymography and quantitated. Active MMP-2 activity of colorectal cancer with liver metastasis group (24.1 ± 2.5 pixel count) was significantly higher than that of colorectal cancer without liver metastasis group (11.4 ± 1.3 pixel count) (P < 0.001) or of control group (6.4 ± 1.0 pixel count) (P < 0.001). Active MMP-9 was not detected in bile. ProMMP-9 activity of colorectal cancer with liver metastasis group (530.3 ± 127.5 pixel count) was significantly higher than that of colorectal cancer without liver metastasis group (213.9 ± 33.2 pixel count) (P = 0.008). This is the first report showing that the levels of active MMP-2 and proMMP-9 in bile were significantly higher in liver metastasis of colorectal cancer than in metastasis-free colorectal cancer. The results suggest that activities of active MMP-2 and proMMP-9 in the bile may be useful markers for predicting liver metastasis in colorectal cancer." @default.
- W2062054260 created "2016-06-24" @default.
- W2062054260 creator A5026016803 @default.
- W2062054260 creator A5056653600 @default.
- W2062054260 creator A5069794075 @default.
- W2062054260 creator A5082519965 @default.
- W2062054260 creator A5084517939 @default.
- W2062054260 creator A5089106164 @default.
- W2062054260 date "2001-10-01" @default.
- W2062054260 modified "2023-10-03" @default.
- W2062054260 title "Matrix Metalloproteinase-2 and -9 in Bile as a Marker of Liver Metastasis in Colorectal Cancer" @default.
- W2062054260 cites W1886431664 @default.
- W2062054260 cites W190590421 @default.
- W2062054260 cites W1967666058 @default.
- W2062054260 cites W1970500968 @default.
- W2062054260 cites W1971328327 @default.
- W2062054260 cites W2005707246 @default.
- W2062054260 cites W2051021771 @default.
- W2062054260 cites W2060848035 @default.
- W2062054260 cites W2067550900 @default.
- W2062054260 cites W2068013043 @default.
- W2062054260 cites W2071362618 @default.
- W2062054260 cites W2075179592 @default.
- W2062054260 cites W2079831464 @default.
- W2062054260 cites W2084130123 @default.
- W2062054260 cites W2090057061 @default.
- W2062054260 cites W2116477272 @default.
- W2062054260 cites W2141142935 @default.
- W2062054260 cites W2146031669 @default.
- W2062054260 cites W2245825504 @default.
- W2062054260 cites W4250908540 @default.
- W2062054260 doi "https://doi.org/10.1006/bbrc.2001.5741" @default.
- W2062054260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11594775" @default.
- W2062054260 hasPublicationYear "2001" @default.
- W2062054260 type Work @default.
- W2062054260 sameAs 2062054260 @default.
- W2062054260 citedByCount "57" @default.
- W2062054260 countsByYear W20620542602012 @default.
- W2062054260 countsByYear W20620542602013 @default.
- W2062054260 countsByYear W20620542602014 @default.
- W2062054260 countsByYear W20620542602015 @default.
- W2062054260 countsByYear W20620542602016 @default.
- W2062054260 countsByYear W20620542602017 @default.
- W2062054260 countsByYear W20620542602018 @default.
- W2062054260 countsByYear W20620542602019 @default.
- W2062054260 countsByYear W20620542602020 @default.
- W2062054260 countsByYear W20620542602022 @default.
- W2062054260 countsByYear W20620542602023 @default.
- W2062054260 crossrefType "journal-article" @default.
- W2062054260 hasAuthorship W2062054260A5026016803 @default.
- W2062054260 hasAuthorship W2062054260A5056653600 @default.
- W2062054260 hasAuthorship W2062054260A5069794075 @default.
- W2062054260 hasAuthorship W2062054260A5082519965 @default.
- W2062054260 hasAuthorship W2062054260A5084517939 @default.
- W2062054260 hasAuthorship W2062054260A5089106164 @default.
- W2062054260 hasConcept C109523444 @default.
- W2062054260 hasConcept C121608353 @default.
- W2062054260 hasConcept C126322002 @default.
- W2062054260 hasConcept C143998085 @default.
- W2062054260 hasConcept C2779013556 @default.
- W2062054260 hasConcept C526805850 @default.
- W2062054260 hasConcept C71924100 @default.
- W2062054260 hasConcept C90924648 @default.
- W2062054260 hasConceptScore W2062054260C109523444 @default.
- W2062054260 hasConceptScore W2062054260C121608353 @default.
- W2062054260 hasConceptScore W2062054260C126322002 @default.
- W2062054260 hasConceptScore W2062054260C143998085 @default.
- W2062054260 hasConceptScore W2062054260C2779013556 @default.
- W2062054260 hasConceptScore W2062054260C526805850 @default.
- W2062054260 hasConceptScore W2062054260C71924100 @default.
- W2062054260 hasConceptScore W2062054260C90924648 @default.
- W2062054260 hasFunder F4320320912 @default.
- W2062054260 hasIssue "1" @default.
- W2062054260 hasLocation W20620542601 @default.
- W2062054260 hasLocation W20620542602 @default.
- W2062054260 hasOpenAccess W2062054260 @default.
- W2062054260 hasPrimaryLocation W20620542601 @default.
- W2062054260 hasRelatedWork W1484342312 @default.
- W2062054260 hasRelatedWork W1970423756 @default.
- W2062054260 hasRelatedWork W2002035242 @default.
- W2062054260 hasRelatedWork W2049872933 @default.
- W2062054260 hasRelatedWork W2088479573 @default.
- W2062054260 hasRelatedWork W2189147744 @default.
- W2062054260 hasRelatedWork W2327949229 @default.
- W2062054260 hasRelatedWork W2799436481 @default.
- W2062054260 hasRelatedWork W3013693150 @default.
- W2062054260 hasRelatedWork W3029726945 @default.
- W2062054260 hasVolume "288" @default.
- W2062054260 isParatext "false" @default.
- W2062054260 isRetracted "false" @default.
- W2062054260 magId "2062054260" @default.
- W2062054260 workType "article" @default.