FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062056987> ?p ?o ?g. }

• W2062056987 abstract "To compare changes in biochemical markers of bone turnover in postmenopausal women who received sequential discontinuous hormone replacement therapy (HRT) with either transdermal 17 beta-estradiol gel (group 1) or oral equine sulfoconjugated estrogen (group 2), plus nomegestrol acetate.Prospective, open, randomized, controlled trial, conducted on 3 parallel groups of 106 postmenopausal women. All treated groups received estrogen therapy for 25 consecutive days every month. The estrogen used was either 1.5 mg/day of transdermal 17 beta-estradiol gel (group 1) [N = 42, average age (AA) = 51.6 years, average duration of menopause (ADM = 21.5 months)], or 0.625 mg/day of oral equine sulfoconjugated estrogen (group 2) [N = 39, AA = 51.3 years, ADM = 16.8 months]. In all cases nomegestrol acetate 5 mg/day was added for 12 consecutive days every month. The control group comprised 25 patients, [AA = 53.4 years, ADM = 33.7 months]. Two bone resorption markers: urinary cross-linked N-telopeptide and C-telopeptide of type I collagen (U-NTX/Cr, U-CTX/Cr), and a bone formation marker: serum bone specific alkaline phosphatase activity were measured before and 6 months after treatment start.Significant decreases from baseline values were observed for the 3 biochemical markers in both treated groups compared with control (P < 0.001). There were no significant differences in changes between the 2 treated groups for the 3 biochemical markers. The mean percentage change in the 3 biochemical markers was: from -9.3 to -45.5% in group 1, from -20.5 to -39% in group 2, and from -3.3 to 2% in control group. In group 1, the mean percentage decreases in U-CTX reached optimal threshold of bone turnover change (-45%) which is considered by the International Osteoporosis Foundation as clinically relevant because it predicts an increase in BMD greater than 3% when treatment is maintained over a long term.Both treated groups induced a significant comparable decrease of bone turnover markers after 6 months of intervention, compared with control. The group treated with cyclic administration of transdermal 17 beta-estradiol (1.5 mg/day) and nomegestrol acetate (5 mg/day) showed a bone resorption markers decrease corresponding to the threshold of clinical relevance described in the international literature and predictive of positive BMD response in long term." @default.
• W2062056987 created "2016-06-24" @default.
• W2062056987 creator A5000506319 @default.
• W2062056987 creator A5014358607 @default.
• W2062056987 creator A5015819007 @default.
• W2062056987 creator A5028502093 @default.
• W2062056987 creator A5042936280 @default.
• W2062056987 creator A5048762070 @default.
• W2062056987 creator A5062387212 @default.
• W2062056987 date "2003-05-01" @default.
• W2062056987 modified "2023-10-16" @default.
• W2062056987 title "Comparaison de l’évolution des marqueurs biologiques du remodelage osseux après six mois de traitement hormonal substitutif par 17β–estradiol cutané ou estrogènes sulfoconjugués équins et acétate de nomégestrol" @default.
• W2062056987 cites W1964321896 @default.
• W2062056987 cites W1976278202 @default.
• W2062056987 cites W1978894035 @default.
• W2062056987 cites W1987401403 @default.
• W2062056987 cites W1990654348 @default.
• W2062056987 cites W1997883187 @default.
• W2062056987 cites W2008998525 @default.
• W2062056987 cites W2012925757 @default.
• W2062056987 cites W2017945794 @default.
• W2062056987 cites W2022794334 @default.
• W2062056987 cites W2023471859 @default.
• W2062056987 cites W2023494445 @default.
• W2062056987 cites W2027852937 @default.
• W2062056987 cites W2032685907 @default.
• W2062056987 cites W2039010341 @default.
• W2062056987 cites W2039608151 @default.
• W2062056987 cites W2046983302 @default.
• W2062056987 cites W2052079718 @default.
• W2062056987 cites W2052858021 @default.
• W2062056987 cites W2057884086 @default.
• W2062056987 cites W2061281314 @default.
• W2062056987 cites W2062229303 @default.
• W2062056987 cites W2062781570 @default.
• W2062056987 cites W2072427778 @default.
• W2062056987 cites W2090037743 @default.
• W2062056987 cites W2093580401 @default.
• W2062056987 cites W2151649765 @default.
• W2062056987 cites W2152747766 @default.
• W2062056987 cites W2154542408 @default.
• W2062056987 cites W2160295774 @default.
• W2062056987 cites W4244405411 @default.
• W2062056987 cites W4245166850 @default.
• W2062056987 cites W4245742228 @default.
• W2062056987 cites W4254382561 @default.
• W2062056987 doi "https://doi.org/10.1016/s1297-9589(03)00118-8" @default.
• W2062056987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14567121" @default.
• W2062056987 hasPublicationYear "2003" @default.
• W2062056987 type Work @default.
• W2062056987 sameAs 2062056987 @default.
• W2062056987 citedByCount "4" @default.
• W2062056987 countsByYear W20620569872021 @default.
• W2062056987 countsByYear W20620569872022 @default.
• W2062056987 crossrefType "journal-article" @default.
• W2062056987 hasAuthorship W2062056987A5000506319 @default.
• W2062056987 hasAuthorship W2062056987A5014358607 @default.
• W2062056987 hasAuthorship W2062056987A5015819007 @default.
• W2062056987 hasAuthorship W2062056987A5028502093 @default.
• W2062056987 hasAuthorship W2062056987A5042936280 @default.
• W2062056987 hasAuthorship W2062056987A5048762070 @default.
• W2062056987 hasAuthorship W2062056987A5062387212 @default.
• W2062056987 hasConcept C29456083 @default.
• W2062056987 hasConcept C71924100 @default.
• W2062056987 hasConceptScore W2062056987C29456083 @default.
• W2062056987 hasConceptScore W2062056987C71924100 @default.
• W2062056987 hasLocation W20620569871 @default.
• W2062056987 hasLocation W20620569872 @default.
• W2062056987 hasOpenAccess W2062056987 @default.
• W2062056987 hasPrimaryLocation W20620569871 @default.
• W2062056987 hasRelatedWork W2012733509 @default.
• W2062056987 hasRelatedWork W2053638911 @default.
• W2062056987 hasRelatedWork W2073545276 @default.
• W2062056987 hasRelatedWork W2077499275 @default.
• W2062056987 hasRelatedWork W2091140190 @default.
• W2062056987 hasRelatedWork W2128714854 @default.
• W2062056987 hasRelatedWork W2132357988 @default.
• W2062056987 hasRelatedWork W2145758813 @default.
• W2062056987 hasRelatedWork W2964737734 @default.
• W2062056987 hasRelatedWork W3192889171 @default.
• W2062056987 isParatext "false" @default.
• W2062056987 isRetracted "false" @default.
• W2062056987 magId "2062056987" @default.
• W2062056987 workType "article" @default.