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- W2062057903 abstract "Alpha-melanocyte stimulating hormone (α-MSH) is a hypothalamic peptide believed to play a tonic inhibitory role in feeding and energy homeostasis. Systemic administration of α-MSH is known to produce anorexia and anxiety. Since synaptic contacts between gamma-aminobutyric acid (GABA)ergic terminals and α-MSH neurons in the hypothalamus have been reported, the present work was undertaken to refine our knowledge on the role of GABAergic systems in anxiety and anorexia induced by intracerebroventricular (icv) administration of α-MSH in rats. The anxiety was assessed by elevated plus maze, and spontaneous food consumption was monitored during dark cycle. Prior administration of diazepam and muscimol that promote the function of GABAA receptors reversed the anxiogenic response and decreased food intake elicited by α-MSH. In contrast, bicuculline, the GABAA receptor antagonist, not only enhanced the effects of α-MSH but also prevented the influence of GABAergic drugs on α-MSH-induced anorexia and anxiety. These findings suggest that α-MSH-induced anxiety and anorexia are due to its negative influence on GABAergic system." @default.
- W2062057903 created "2016-06-24" @default.
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- W2062057903 date "2003-12-01" @default.
- W2062057903 modified "2023-10-12" @default.
- W2062057903 title "GABAergic agents prevent alpha-melanocyte stimulating hormone induced anxiety and anorexia in rats" @default.
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- W2062057903 doi "https://doi.org/10.1016/j.pbb.2003.08.016" @default.
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