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- W2062073071 abstract "Recent advances in genomics and molecular pathogenesis studies have determined that many diseases are caused by a multiplicity of factors. New drug regimens may consist of multiple biologically active agents designed to act synergistically on multiple biochemical targets. Live cell assays are becoming a standard for identifying new drug candidates with an emphasis on homogeneous living cell assays in which multiple cell lines are mixed and monitored simultaneously. In this study, we used a high-density single living cell array, based on an optical imaging fiber bundle microwell array, to simultaneously monitor promiscuous drug effects on single cells of multiple cell types. Such a capability allows for a more comprehensive understanding of how cells dynamically respond to combinatorial drug libraries or how different cellular pathways and regulation circuits respond cooperatively to drugs in individual cells." @default.
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- W2062073071 date "2005-10-01" @default.
- W2062073071 modified "2023-09-23" @default.
- W2062073071 title "Monitoring “promiscuous” drug effects on single cells of multiple cell types" @default.
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- W2062073071 doi "https://doi.org/10.1016/j.ab.2005.06.028" @default.
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