Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062075767> ?p ?o ?g. }
- W2062075767 endingPage "1741" @default.
- W2062075767 startingPage "1728" @default.
- W2062075767 abstract "Abstract Color vision requires the expression of opsin photopigments with different wavelength sensitivities in retinal cone photoreceptors. The basic color visual system of mammals is dichromatic, involving differential expression in the cone population of two opsins with sensitivity to short (S, blue) or medium (M, green) wavelengths. However, little is known of the factors that directly activate these opsin genes and thereby contribute to the S or M opsin identity of the cone. We report that the orphan nuclear receptor RORβ (retinoid-related orphan receptor β) activates the S opsin gene (Opn1sw) through binding sites upstream of the gene. RORβ lacks a known physiological ligand and activates the Opn1sw promoter modestly alone but strongly in synergy with the retinal cone-rod homeobox factor (CRX), suggesting a cooperative means of enhancing RORβ activity. Comparison of wild-type and mutant lacZ reporter transgenes showed that the RORβ-binding sites in Opn1sw are required for expression in mouse retina. RORβ-deficient mice fail to induce S opsin appropriately during postnatal cone development. Photoreceptors in these mice also lack outer segments, indicating additional functions for RORβ in photoreceptor morphological maturation. The results identify Opn1sw as a target gene for RORβ and suggest a key role for RORβ in regulating opsin expression in the color visual system." @default.
- W2062075767 created "2016-06-24" @default.
- W2062075767 creator A5004725003 @default.
- W2062075767 creator A5044718043 @default.
- W2062075767 creator A5057287134 @default.
- W2062075767 creator A5063573320 @default.
- W2062075767 creator A5078466519 @default.
- W2062075767 date "2006-08-01" @default.
- W2062075767 modified "2023-09-28" @default.
- W2062075767 title "Activation of the Blue Opsin Gene in Cone Photoreceptor Development by Retinoid-Related Orphan Receptor β" @default.
- W2062075767 cites W1525882285 @default.
- W2062075767 cites W1526137086 @default.
- W2062075767 cites W1597109281 @default.
- W2062075767 cites W1732752544 @default.
- W2062075767 cites W1961457995 @default.
- W2062075767 cites W1967195106 @default.
- W2062075767 cites W1968703962 @default.
- W2062075767 cites W1977249990 @default.
- W2062075767 cites W1985050375 @default.
- W2062075767 cites W1987510697 @default.
- W2062075767 cites W1997660442 @default.
- W2062075767 cites W2002352369 @default.
- W2062075767 cites W2014348752 @default.
- W2062075767 cites W2016730049 @default.
- W2062075767 cites W2018563312 @default.
- W2062075767 cites W2022734550 @default.
- W2062075767 cites W2027066480 @default.
- W2062075767 cites W2028545666 @default.
- W2062075767 cites W2028868015 @default.
- W2062075767 cites W2032480645 @default.
- W2062075767 cites W2033991895 @default.
- W2062075767 cites W2039764427 @default.
- W2062075767 cites W2043817535 @default.
- W2062075767 cites W2051603449 @default.
- W2062075767 cites W2056970098 @default.
- W2062075767 cites W2058877341 @default.
- W2062075767 cites W2059130093 @default.
- W2062075767 cites W2059344357 @default.
- W2062075767 cites W2066556283 @default.
- W2062075767 cites W2070394325 @default.
- W2062075767 cites W2072414883 @default.
- W2062075767 cites W2075365540 @default.
- W2062075767 cites W2077520670 @default.
- W2062075767 cites W2082177594 @default.
- W2062075767 cites W2091302363 @default.
- W2062075767 cites W2097163584 @default.
- W2062075767 cites W2099545629 @default.
- W2062075767 cites W2129618668 @default.
- W2062075767 cites W2134168057 @default.
- W2062075767 cites W2136899592 @default.
- W2062075767 cites W2150941121 @default.
- W2062075767 cites W2152214759 @default.
- W2062075767 cites W2157191738 @default.
- W2062075767 cites W2158479544 @default.
- W2062075767 cites W2160692145 @default.
- W2062075767 cites W2411181147 @default.
- W2062075767 doi "https://doi.org/10.1210/me.2005-0505" @default.
- W2062075767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16574740" @default.
- W2062075767 hasPublicationYear "2006" @default.
- W2062075767 type Work @default.
- W2062075767 sameAs 2062075767 @default.
- W2062075767 citedByCount "99" @default.
- W2062075767 countsByYear W20620757672012 @default.
- W2062075767 countsByYear W20620757672013 @default.
- W2062075767 countsByYear W20620757672014 @default.
- W2062075767 countsByYear W20620757672015 @default.
- W2062075767 countsByYear W20620757672016 @default.
- W2062075767 countsByYear W20620757672017 @default.
- W2062075767 countsByYear W20620757672018 @default.
- W2062075767 countsByYear W20620757672019 @default.
- W2062075767 countsByYear W20620757672020 @default.
- W2062075767 countsByYear W20620757672021 @default.
- W2062075767 countsByYear W20620757672022 @default.
- W2062075767 countsByYear W20620757672023 @default.
- W2062075767 crossrefType "journal-article" @default.
- W2062075767 hasAuthorship W2062075767A5004725003 @default.
- W2062075767 hasAuthorship W2062075767A5044718043 @default.
- W2062075767 hasAuthorship W2062075767A5057287134 @default.
- W2062075767 hasAuthorship W2062075767A5063573320 @default.
- W2062075767 hasAuthorship W2062075767A5078466519 @default.
- W2062075767 hasBestOaLocation W20620757671 @default.
- W2062075767 hasConcept C102230213 @default.
- W2062075767 hasConcept C104317684 @default.
- W2062075767 hasConcept C121587040 @default.
- W2062075767 hasConcept C189780591 @default.
- W2062075767 hasConcept C202033177 @default.
- W2062075767 hasConcept C2779161069 @default.
- W2062075767 hasConcept C2780827179 @default.
- W2062075767 hasConcept C30028475 @default.
- W2062075767 hasConcept C54355233 @default.
- W2062075767 hasConcept C55493867 @default.
- W2062075767 hasConcept C86339819 @default.
- W2062075767 hasConcept C86803240 @default.
- W2062075767 hasConcept C95444343 @default.
- W2062075767 hasConceptScore W2062075767C102230213 @default.
- W2062075767 hasConceptScore W2062075767C104317684 @default.
- W2062075767 hasConceptScore W2062075767C121587040 @default.
- W2062075767 hasConceptScore W2062075767C189780591 @default.