Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062079595> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2062079595 endingPage "1014" @default.
- W2062079595 startingPage "1007" @default.
- W2062079595 abstract "The effect of metoprolol, a new beta1-adrenoceptor blocking agent, was compared to practolol in the treatment of hypertension in seventeen asthmatics during concurrent optimum bronchodilator therapy with a selective beta2-adrenoceptor-stimulant. The two beta-adrenoceptor antagonists were given at two dose levels, practolol (200 mg and 400 mg) daily, and metoprolol (100 mg and 200 mg) daily, in a twice-daily dosage schedule, at 12 h intervals, for 17 days. The comparison was made double-blind and a crossover design was used. The drugs were given in randomized order. The study started with a run-in placebo period and there was a washout period on placebo between the treatment periods. Spirometry, blood pressures and heart rates were recorded in a standardized manner. At the lower dose levels no influence on FEV1 was noted, and no difference was found between the two active drugs. At the higher dose level FEV1 was reduced by both beta-adrenoceptor-blocking drugs. Four out of twelve patients given the higher dose experienced exacerbation of their asthma. The heart rate fell with both drugs and at both dose levels. During the placebo period a marked increase of heart rate was noted. The blood pressure fell at both dose levels compared to placebo, no difference being recorded between the two drugs. Metoprolol and practolol are equally effective beta1-adrenoceptor blocking drugs. In this study it was found that metoprolol could be used in asthmatics who had indications for beta-adrenoceptor blockade, provided that the total daily dose did not exceed 100 mg. Optimal bronchodilator treatment with a bronchoselective beta-adrenoceptor agonist is an absolute prerequisite in order to avoid the risk of aggravation of asthma." @default.
- W2062079595 created "2016-06-24" @default.
- W2062079595 creator A5000867692 @default.
- W2062079595 date "1976-12-01" @default.
- W2062079595 modified "2023-09-26" @default.
- W2062079595 title "THE EFFECT OF METOPROLOL AND PRACTOLOL ON LUNG FUNCTION AND BLOOD PRESSURE IN HYPERTENSIVE ASTHMATICS" @default.
- W2062079595 cites W1971047206 @default.
- W2062079595 cites W2006343870 @default.
- W2062079595 cites W2022571749 @default.
- W2062079595 cites W2029234913 @default.
- W2062079595 cites W2038809152 @default.
- W2062079595 cites W2042426748 @default.
- W2062079595 cites W2047908335 @default.
- W2062079595 cites W2056710114 @default.
- W2062079595 cites W2078461068 @default.
- W2062079595 cites W2087876837 @default.
- W2062079595 cites W2151021249 @default.
- W2062079595 cites W2340753777 @default.
- W2062079595 doi "https://doi.org/10.1111/j.1365-2125.1976.tb00350.x" @default.
- W2062079595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1428965" @default.
- W2062079595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22216522" @default.
- W2062079595 hasPublicationYear "1976" @default.
- W2062079595 type Work @default.
- W2062079595 sameAs 2062079595 @default.
- W2062079595 citedByCount "86" @default.
- W2062079595 countsByYear W20620795952012 @default.
- W2062079595 countsByYear W20620795952013 @default.
- W2062079595 crossrefType "journal-article" @default.
- W2062079595 hasAuthorship W2062079595A5000867692 @default.
- W2062079595 hasBestOaLocation W20620795951 @default.
- W2062079595 hasConcept C126322002 @default.
- W2062079595 hasConcept C142724271 @default.
- W2062079595 hasConcept C204787440 @default.
- W2062079595 hasConcept C27081682 @default.
- W2062079595 hasConcept C2776042228 @default.
- W2062079595 hasConcept C2776663762 @default.
- W2062079595 hasConcept C2777394947 @default.
- W2062079595 hasConcept C2777953023 @default.
- W2062079595 hasConcept C2778151854 @default.
- W2062079595 hasConcept C2780333948 @default.
- W2062079595 hasConcept C2781018748 @default.
- W2062079595 hasConcept C2781280847 @default.
- W2062079595 hasConcept C42219234 @default.
- W2062079595 hasConcept C71924100 @default.
- W2062079595 hasConcept C84393581 @default.
- W2062079595 hasConcept C87813604 @default.
- W2062079595 hasConcept C98274493 @default.
- W2062079595 hasConceptScore W2062079595C126322002 @default.
- W2062079595 hasConceptScore W2062079595C142724271 @default.
- W2062079595 hasConceptScore W2062079595C204787440 @default.
- W2062079595 hasConceptScore W2062079595C27081682 @default.
- W2062079595 hasConceptScore W2062079595C2776042228 @default.
- W2062079595 hasConceptScore W2062079595C2776663762 @default.
- W2062079595 hasConceptScore W2062079595C2777394947 @default.
- W2062079595 hasConceptScore W2062079595C2777953023 @default.
- W2062079595 hasConceptScore W2062079595C2778151854 @default.
- W2062079595 hasConceptScore W2062079595C2780333948 @default.
- W2062079595 hasConceptScore W2062079595C2781018748 @default.
- W2062079595 hasConceptScore W2062079595C2781280847 @default.
- W2062079595 hasConceptScore W2062079595C42219234 @default.
- W2062079595 hasConceptScore W2062079595C71924100 @default.
- W2062079595 hasConceptScore W2062079595C84393581 @default.
- W2062079595 hasConceptScore W2062079595C87813604 @default.
- W2062079595 hasConceptScore W2062079595C98274493 @default.
- W2062079595 hasIssue "6" @default.
- W2062079595 hasLocation W20620795951 @default.
- W2062079595 hasLocation W20620795952 @default.
- W2062079595 hasLocation W20620795953 @default.
- W2062079595 hasLocation W20620795954 @default.
- W2062079595 hasOpenAccess W2062079595 @default.
- W2062079595 hasPrimaryLocation W20620795951 @default.
- W2062079595 hasRelatedWork W129329257 @default.
- W2062079595 hasRelatedWork W1805916934 @default.
- W2062079595 hasRelatedWork W1966508173 @default.
- W2062079595 hasRelatedWork W2055279203 @default.
- W2062079595 hasRelatedWork W2062079595 @default.
- W2062079595 hasRelatedWork W2129708432 @default.
- W2062079595 hasRelatedWork W2147862540 @default.
- W2062079595 hasRelatedWork W2252156554 @default.
- W2062079595 hasRelatedWork W3213929234 @default.
- W2062079595 hasRelatedWork W3217809583 @default.
- W2062079595 hasVolume "3" @default.
- W2062079595 isParatext "false" @default.
- W2062079595 isRetracted "false" @default.
- W2062079595 magId "2062079595" @default.
- W2062079595 workType "article" @default.