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• W2062084429 abstract "Our previous studies have shown that stimulation of mu-opioid receptors within the nucleus accumbens preferentially enhances intake of palatable food containing sucrose and fat; thus, opioids in this brain area may mediate the rewarding characteristics of food by modulating taste and macronutrient preference. The present study was designed to further explore the nature of the involvement of striatal opioids in feeding behavior, such as the location of sensitive subregions of the ventral striatum and the brain neural circuits involved in opioid-mediated hyperphagia. In Experiment 1, we conducted a microinfusion mapping study of feeding behavior by microinfusion of the mu receptor agonist, d-Ala2,NMe-Phe4,Glyol5-enkephalin (0, 0.025 and 0.25 μg/0.5 μl per side; equivalent to 0, 0.04 and 0.40 nmol/0.5 μl per side), into several striatal subregions. In Experiment 2, detection of the expression of the immediate early gene, c-fos, was used to examine brain areas activated following intra-striatal microinfusion of d-Ala2,NMe-Phe4,Glyol5-enkephalin. The microinjection mapping study demonstrated a broad anatomical gradient within the striatum, with sensitivity highest in relatively more lateral and ventral regions of the striatum (ventrolateral striatum, lateral shell and core). The Fos mapping study demonstrated that circuitry including hypothalamic areas, the ventral tegmental area, the substantia nigra and the nucleus of the solitary tract was recruited by stimulation of mu receptors within the nucleus accumbens. A similar pattern was observed following stimulation of mu receptors in the dorsal striatum; however, the extent of activation was much smaller in magnitude. These results suggest that the role of mu receptors within the striatum in palatable feeding primarily involves ventral and lateral regions. Moreover, the pattern of activation in hypothalamic, midbrain and gustatory–visceral relay areas suggests that striatal mu receptors may participate in integrating motivational, metabolic and autonomic aspects of ingestive behavior." @default.
• W2062084429 created "2016-06-24" @default.
• W2062084429 creator A5018633729 @default.
• W2062084429 creator A5019974637 @default.
• W2062084429 date "2000-09-01" @default.
• W2062084429 modified "2023-09-30" @default.
• W2062084429 title "Enhanced intake of high-fat food following striatal mu-opioid stimulation: microinjection mapping and Fos expression" @default.
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• W2062084429 doi "https://doi.org/10.1016/s0306-4522(00)00198-6" @default.
• W2062084429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10938432" @default.
• W2062084429 hasPublicationYear "2000" @default.
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