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- W2062103118 abstract "To evaluate the role of intrastromal injection of voriconazole in the management of deep recalcitrant fungal keratitis.Interventional case series.Cornea services at a tertiary care teaching hospital.Three eyes of three patients with deep stromal recalcitrant fungal keratitis not responding to topical antifungal medications. Intervention Procedure: Voriconazole 50 micrograms/0.1 ml was injected circumferentially around the fungal abscess in the corneal stroma as an adjunctive to the topical antifungal therapy.Main outcome measure was a reduction in size of the abscess and resolution of the infection.Before the intracorneal injection, all three eyes had gradually worsening lesions on topical medications. After the intervention, a faster reduction in the size of corneal infiltration was documented and a complete resolution of the ulcers was seen within three weeks in all cases.Targeted delivery of voriconazole by intracorneal injection may be a safe and effective way to treat cases of deep-seated recalcitrant fungal keratitis responding poorly to conventional treatment modalities." @default.
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- W2062103118 date "2008-07-01" @default.
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- W2062103118 title "Evaluation of Intrastromal Injection of Voriconazole as a Therapeutic Adjunctive for the Management of Deep Recalcitrant Fungal Keratitis" @default.
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- W2062103118 doi "https://doi.org/10.1016/j.ajo.2008.02.023" @default.
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