Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062109170> ?p ?o ?g. }
- W2062109170 endingPage "89" @default.
- W2062109170 startingPage "82" @default.
- W2062109170 abstract "In the vertebrate retina, melatonin is synthesized by the photoreceptors with high levels of melatonin at night and lower levels during the day. Melatonin exerts its influence by interacting with a family of G-protein-coupled receptors that are negatively coupled with adenylyl cyclase. Melatonin receptors belonging to the subtypes MT1 and MT2 have been identified in the mammalian retina. MT1 and MT2 receptors are found in all layers of the neural retina and in the retinal pigmented epithelium. Melatonin in the eye is believed to be involved in the modulation of many important retinal functions; it can modulate the electroretinogram (ERG), and administration of exogenous melatonin increases light-induced photoreceptor degeneration. Melatonin may also have protective effects on retinal pigment epithelial cells, photoreceptors and ganglion cells. A series of studies have implicated melatonin in the pathogenesis of age-related macular degeneration, and melatonin administration may represent a useful approach to prevent and treat glaucoma. Melatonin is used by millions of people around the world to retard aging, improve sleep performance, mitigate jet lag symptoms, and treat depression. Administration of exogenous melatonin at night may also be beneficial for ocular health, but additional investigation is needed to establish its potential." @default.
- W2062109170 created "2016-06-24" @default.
- W2062109170 creator A5027521180 @default.
- W2062109170 creator A5029520164 @default.
- W2062109170 creator A5038263865 @default.
- W2062109170 creator A5087080862 @default.
- W2062109170 date "2012-10-01" @default.
- W2062109170 modified "2023-10-12" @default.
- W2062109170 title "Melatonin: An underappreciated player in retinal physiology and pathophysiology" @default.
- W2062109170 cites W116577186 @default.
- W2062109170 cites W1562048214 @default.
- W2062109170 cites W1579934867 @default.
- W2062109170 cites W1581362348 @default.
- W2062109170 cites W1591384720 @default.
- W2062109170 cites W1766360407 @default.
- W2062109170 cites W1799479235 @default.
- W2062109170 cites W1882703193 @default.
- W2062109170 cites W1948072384 @default.
- W2062109170 cites W1964877886 @default.
- W2062109170 cites W1965220993 @default.
- W2062109170 cites W1965221598 @default.
- W2062109170 cites W1970728427 @default.
- W2062109170 cites W1970774549 @default.
- W2062109170 cites W1971933392 @default.
- W2062109170 cites W1972651922 @default.
- W2062109170 cites W1973010465 @default.
- W2062109170 cites W1973171621 @default.
- W2062109170 cites W1975811281 @default.
- W2062109170 cites W1977498929 @default.
- W2062109170 cites W1978449206 @default.
- W2062109170 cites W1979755306 @default.
- W2062109170 cites W1982804405 @default.
- W2062109170 cites W1983004978 @default.
- W2062109170 cites W1985581496 @default.
- W2062109170 cites W1986751457 @default.
- W2062109170 cites W1987410085 @default.
- W2062109170 cites W1987638303 @default.
- W2062109170 cites W1987938124 @default.
- W2062109170 cites W1990425248 @default.
- W2062109170 cites W1991186732 @default.
- W2062109170 cites W1991691552 @default.
- W2062109170 cites W1996754070 @default.
- W2062109170 cites W1999929622 @default.
- W2062109170 cites W2003184463 @default.
- W2062109170 cites W2003576389 @default.
- W2062109170 cites W2006542228 @default.
- W2062109170 cites W2006664244 @default.
- W2062109170 cites W2006994655 @default.
- W2062109170 cites W2007083862 @default.
- W2062109170 cites W2007344050 @default.
- W2062109170 cites W2007395018 @default.
- W2062109170 cites W2010673665 @default.
- W2062109170 cites W2013890294 @default.
- W2062109170 cites W2014625058 @default.
- W2062109170 cites W2015625688 @default.
- W2062109170 cites W2016430267 @default.
- W2062109170 cites W2018078485 @default.
- W2062109170 cites W2018730233 @default.
- W2062109170 cites W2022364867 @default.
- W2062109170 cites W2023231528 @default.
- W2062109170 cites W2025047181 @default.
- W2062109170 cites W2027999012 @default.
- W2062109170 cites W2028746974 @default.
- W2062109170 cites W2029821895 @default.
- W2062109170 cites W2030010171 @default.
- W2062109170 cites W2032337451 @default.
- W2062109170 cites W2033960866 @default.
- W2062109170 cites W2034849053 @default.
- W2062109170 cites W2035024442 @default.
- W2062109170 cites W2036596005 @default.
- W2062109170 cites W2037684677 @default.
- W2062109170 cites W2038621376 @default.
- W2062109170 cites W2039413757 @default.
- W2062109170 cites W2042233223 @default.
- W2062109170 cites W2042397231 @default.
- W2062109170 cites W2043575355 @default.
- W2062109170 cites W2045169829 @default.
- W2062109170 cites W2045547589 @default.
- W2062109170 cites W2045982402 @default.
- W2062109170 cites W2048168703 @default.
- W2062109170 cites W2048252930 @default.
- W2062109170 cites W2048558358 @default.
- W2062109170 cites W2049968846 @default.
- W2062109170 cites W2051620236 @default.
- W2062109170 cites W2051747007 @default.
- W2062109170 cites W2053310140 @default.
- W2062109170 cites W2054676224 @default.
- W2062109170 cites W2057505001 @default.
- W2062109170 cites W2060132255 @default.
- W2062109170 cites W2060266281 @default.
- W2062109170 cites W2065499119 @default.
- W2062109170 cites W2066119514 @default.
- W2062109170 cites W2066199795 @default.
- W2062109170 cites W2066565428 @default.
- W2062109170 cites W2067077994 @default.
- W2062109170 cites W2067588115 @default.
- W2062109170 cites W2067641362 @default.
- W2062109170 cites W2067674238 @default.