FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062113336> ?p ?o ?g. }

• W2062113336 endingPage "170" @default.
• W2062113336 startingPage "165" @default.
• W2062113336 abstract "Chronic brain inflammation is the common final pathway in the majority of neurodegenerative diseases and central to this phenomenon is the immunological activation of brain mononuclear phagocyte cells, called microglia. This inflammatory mechanism is a central component of HIV-associated dementia (HAD). In the healthy state, there are endogenous signals from neurons and astrocytes, which limit excessive central nervous system (CNS) inflammation. However, the signals controlling this process have not been fully elucidated. Studies on the peripheral nervous system suggest that a cholinergic anti-inflammatory pathway regulates systemic inflammatory response by way of acetylcholine acting at the α7 nicotinic acetylcholine receptor (α7nAChR) found on blood-borne macrophages. Recent data from our laboratory indicates that cultured microglial cells also express this same receptor and that microglial anti-inflammatory properties are mediated through it and the p44/42 mitogen-activated protein kinase (MAPK) system. Here we report for the first time the creation of an in vitro model of HAD composed of cultured microglial cells synergistically activated by the addition of IFN-γ and the HIV-1 coat glycoprotein, gp120. Furthermore, this activation, as measured by TNF-α and nitric oxide (NO) release, is synergistically attenuated through the α7 nAChR and p44/42 MAPK system by pretreatment with nicotine, and the cholinesterase inhibitor, galantamine. Our findings suggest a novel therapeutic combination to treat or prevent the onset of HAD through this modulation of the microglia inflammatory mechanism." @default.
• W2062113336 created "2016-06-24" @default.
• W2062113336 creator A5007053933 @default.
• W2062113336 creator A5014564524 @default.
• W2062113336 creator A5042557844 @default.
• W2062113336 creator A5056051023 @default.
• W2062113336 creator A5071988109 @default.
• W2062113336 creator A5075278919 @default.
• W2062113336 creator A5077619051 @default.
• W2062113336 creator A5080768607 @default.
• W2062113336 date "2004-08-01" @default.
• W2062113336 modified "2023-10-15" @default.
• W2062113336 title "Galantamine and nicotine have a synergistic effect on inhibition of microglial activation induced by HIV-1 gp120" @default.
• W2062113336 cites W1605085109 @default.
• W2062113336 cites W1982675296 @default.
• W2062113336 cites W1999733628 @default.
• W2062113336 cites W2005693430 @default.
• W2062113336 cites W2052543965 @default.
• W2062113336 cites W2063858805 @default.
• W2062113336 cites W2064907419 @default.
• W2062113336 cites W2067360858 @default.
• W2062113336 cites W2073295417 @default.
• W2062113336 cites W2080117718 @default.
• W2062113336 cites W2089556791 @default.
• W2062113336 cites W2108585889 @default.
• W2062113336 cites W2115650832 @default.
• W2062113336 cites W2155997108 @default.
• W2062113336 cites W2163773820 @default.
• W2062113336 cites W2169184332 @default.
• W2062113336 cites W2323859250 @default.
• W2062113336 cites W4238596965 @default.
• W2062113336 doi "https://doi.org/10.1016/j.brainresbull.2004.06.008" @default.
• W2062113336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15342104" @default.
• W2062113336 hasPublicationYear "2004" @default.
• W2062113336 type Work @default.
• W2062113336 sameAs 2062113336 @default.
• W2062113336 citedByCount "68" @default.
• W2062113336 countsByYear W20621133362012 @default.
• W2062113336 countsByYear W20621133362013 @default.
• W2062113336 countsByYear W20621133362014 @default.
• W2062113336 countsByYear W20621133362015 @default.
• W2062113336 countsByYear W20621133362016 @default.
• W2062113336 countsByYear W20621133362017 @default.
• W2062113336 countsByYear W20621133362018 @default.
• W2062113336 countsByYear W20621133362019 @default.
• W2062113336 countsByYear W20621133362020 @default.
• W2062113336 countsByYear W20621133362021 @default.
• W2062113336 countsByYear W20621133362022 @default.
• W2062113336 countsByYear W20621133362023 @default.
• W2062113336 crossrefType "journal-article" @default.
• W2062113336 hasAuthorship W2062113336A5007053933 @default.
• W2062113336 hasAuthorship W2062113336A5014564524 @default.
• W2062113336 hasAuthorship W2062113336A5042557844 @default.
• W2062113336 hasAuthorship W2062113336A5056051023 @default.
• W2062113336 hasAuthorship W2062113336A5071988109 @default.
• W2062113336 hasAuthorship W2062113336A5075278919 @default.
• W2062113336 hasAuthorship W2062113336A5077619051 @default.
• W2062113336 hasAuthorship W2062113336A5080768607 @default.
• W2062113336 hasConcept C126322002 @default.
• W2062113336 hasConcept C169760540 @default.
• W2062113336 hasConcept C203014093 @default.
• W2062113336 hasConcept C22885893 @default.
• W2062113336 hasConcept C2775910092 @default.
• W2062113336 hasConcept C2776914184 @default.
• W2062113336 hasConcept C2779056891 @default.
• W2062113336 hasConcept C2779134260 @default.
• W2062113336 hasConcept C2779483572 @default.
• W2062113336 hasConcept C2779547902 @default.
• W2062113336 hasConcept C2779830541 @default.
• W2062113336 hasConcept C2780904820 @default.
• W2062113336 hasConcept C529278444 @default.
• W2062113336 hasConcept C57074206 @default.
• W2062113336 hasConcept C62478195 @default.
• W2062113336 hasConcept C71924100 @default.
• W2062113336 hasConcept C86803240 @default.
• W2062113336 hasConcept C87753298 @default.
• W2062113336 hasConcept C95444343 @default.
• W2062113336 hasConcept C98274493 @default.
• W2062113336 hasConceptScore W2062113336C126322002 @default.
• W2062113336 hasConceptScore W2062113336C169760540 @default.
• W2062113336 hasConceptScore W2062113336C203014093 @default.
• W2062113336 hasConceptScore W2062113336C22885893 @default.
• W2062113336 hasConceptScore W2062113336C2775910092 @default.
• W2062113336 hasConceptScore W2062113336C2776914184 @default.
• W2062113336 hasConceptScore W2062113336C2779056891 @default.
• W2062113336 hasConceptScore W2062113336C2779134260 @default.
• W2062113336 hasConceptScore W2062113336C2779483572 @default.
• W2062113336 hasConceptScore W2062113336C2779547902 @default.
• W2062113336 hasConceptScore W2062113336C2779830541 @default.
• W2062113336 hasConceptScore W2062113336C2780904820 @default.
• W2062113336 hasConceptScore W2062113336C529278444 @default.
• W2062113336 hasConceptScore W2062113336C57074206 @default.
• W2062113336 hasConceptScore W2062113336C62478195 @default.
• W2062113336 hasConceptScore W2062113336C71924100 @default.
• W2062113336 hasConceptScore W2062113336C86803240 @default.
• W2062113336 hasConceptScore W2062113336C87753298 @default.
• W2062113336 hasConceptScore W2062113336C95444343 @default.
• W2062113336 hasConceptScore W2062113336C98274493 @default.

• next