Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062130425> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2062130425 endingPage "483" @default.
- W2062130425 startingPage "479" @default.
- W2062130425 abstract "Low-dose dopamine (LDD) is commonly used after kidney transplantation as a renoprotective agent, although the benefits of dopamine (DA) in this setting are controversial. LDD increases renal blood flow, decreases resistive index (RI) and causes diuresis in normal kidneys. We hypothesised that the vasculature of a denervated renal transplant may not respond to DA in the same way as healthy native kidneys. In a prospective, controlled study, renal blood flow velocity and vascular resistance were measured by Doppler ultrasound in recent kidney transplants (n=20) over a range of DA doses (0–5 μg/kg/min). Main renal artery velocity was lower in kidneys with acute renal dysfunction than in those with normal function (0.60±0.31 vs. 0.81±0.24, respectively, p<0.05). There was no demonstrable haemodynamic effect of LDD on either RI or main renal artery velocity as measured by Doppler ultrasound. Interestingly, the only significant correlation with mean RI was trough cyclosporin A level (r=0.57, p<0.001). Technical or timing factors cannot be used to explain the absence of DA effect, with equivalent doses capable of producing vasodilatation and reduced RI in studies of normal kidneys. In summary, these findings contrast the DA response of healthy native kidneys and may explain studies showing no clinical benefit of LDD in the early post-transplant period. These data suggest an insensitivity of recently implanted kidneys to the vasodilatory effects of LDD, that other factors such as cyclosporin A vasoconstriction may also be important, and question the rationale for routine LDD after kidney transplantation." @default.
- W2062130425 created "2016-06-24" @default.
- W2062130425 creator A5023406339 @default.
- W2062130425 creator A5030971303 @default.
- W2062130425 creator A5051855419 @default.
- W2062130425 creator A5069712013 @default.
- W2062130425 creator A5069847562 @default.
- W2062130425 date "1999-12-01" @default.
- W2062130425 modified "2023-09-30" @default.
- W2062130425 title "Low-dose dopamine after kidney transplantation: assessment by Doppler ultrasound" @default.
- W2062130425 cites W1969988652 @default.
- W2062130425 cites W1994711516 @default.
- W2062130425 cites W1999503243 @default.
- W2062130425 cites W2000811753 @default.
- W2062130425 cites W2028878412 @default.
- W2062130425 cites W2035303646 @default.
- W2062130425 cites W2051382489 @default.
- W2062130425 cites W2072661269 @default.
- W2062130425 cites W2112874964 @default.
- W2062130425 cites W2118752120 @default.
- W2062130425 cites W2214431305 @default.
- W2062130425 cites W2408812855 @default.
- W2062130425 cites W4230996544 @default.
- W2062130425 cites W85338961 @default.
- W2062130425 doi "https://doi.org/10.1034/j.1399-0012.1999.130607.x" @default.
- W2062130425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10617237" @default.
- W2062130425 hasPublicationYear "1999" @default.
- W2062130425 type Work @default.
- W2062130425 sameAs 2062130425 @default.
- W2062130425 citedByCount "16" @default.
- W2062130425 countsByYear W20621304252012 @default.
- W2062130425 countsByYear W20621304252014 @default.
- W2062130425 countsByYear W20621304252017 @default.
- W2062130425 countsByYear W20621304252019 @default.
- W2062130425 countsByYear W20621304252021 @default.
- W2062130425 countsByYear W20621304252023 @default.
- W2062130425 crossrefType "journal-article" @default.
- W2062130425 hasAuthorship W2062130425A5023406339 @default.
- W2062130425 hasAuthorship W2062130425A5030971303 @default.
- W2062130425 hasAuthorship W2062130425A5051855419 @default.
- W2062130425 hasAuthorship W2062130425A5069712013 @default.
- W2062130425 hasAuthorship W2062130425A5069847562 @default.
- W2062130425 hasConcept C120770815 @default.
- W2062130425 hasConcept C126322002 @default.
- W2062130425 hasConcept C126894567 @default.
- W2062130425 hasConcept C142225936 @default.
- W2062130425 hasConcept C158846371 @default.
- W2062130425 hasConcept C159641895 @default.
- W2062130425 hasConcept C164705383 @default.
- W2062130425 hasConcept C178853913 @default.
- W2062130425 hasConcept C2776634560 @default.
- W2062130425 hasConcept C2779547328 @default.
- W2062130425 hasConcept C2779961880 @default.
- W2062130425 hasConcept C2780091579 @default.
- W2062130425 hasConcept C2780303639 @default.
- W2062130425 hasConcept C2781073237 @default.
- W2062130425 hasConcept C2911091166 @default.
- W2062130425 hasConcept C58245268 @default.
- W2062130425 hasConcept C71924100 @default.
- W2062130425 hasConceptScore W2062130425C120770815 @default.
- W2062130425 hasConceptScore W2062130425C126322002 @default.
- W2062130425 hasConceptScore W2062130425C126894567 @default.
- W2062130425 hasConceptScore W2062130425C142225936 @default.
- W2062130425 hasConceptScore W2062130425C158846371 @default.
- W2062130425 hasConceptScore W2062130425C159641895 @default.
- W2062130425 hasConceptScore W2062130425C164705383 @default.
- W2062130425 hasConceptScore W2062130425C178853913 @default.
- W2062130425 hasConceptScore W2062130425C2776634560 @default.
- W2062130425 hasConceptScore W2062130425C2779547328 @default.
- W2062130425 hasConceptScore W2062130425C2779961880 @default.
- W2062130425 hasConceptScore W2062130425C2780091579 @default.
- W2062130425 hasConceptScore W2062130425C2780303639 @default.
- W2062130425 hasConceptScore W2062130425C2781073237 @default.
- W2062130425 hasConceptScore W2062130425C2911091166 @default.
- W2062130425 hasConceptScore W2062130425C58245268 @default.
- W2062130425 hasConceptScore W2062130425C71924100 @default.
- W2062130425 hasIssue "6" @default.
- W2062130425 hasLocation W20621304251 @default.
- W2062130425 hasLocation W20621304252 @default.
- W2062130425 hasOpenAccess W2062130425 @default.
- W2062130425 hasPrimaryLocation W20621304251 @default.
- W2062130425 hasRelatedWork W1264394838 @default.
- W2062130425 hasRelatedWork W1970567743 @default.
- W2062130425 hasRelatedWork W1988170506 @default.
- W2062130425 hasRelatedWork W2038210690 @default.
- W2062130425 hasRelatedWork W2046588908 @default.
- W2062130425 hasRelatedWork W2052195065 @default.
- W2062130425 hasRelatedWork W2312755145 @default.
- W2062130425 hasRelatedWork W2410062415 @default.
- W2062130425 hasRelatedWork W2443902849 @default.
- W2062130425 hasRelatedWork W4290111788 @default.
- W2062130425 hasVolume "13" @default.
- W2062130425 isParatext "false" @default.
- W2062130425 isRetracted "false" @default.
- W2062130425 magId "2062130425" @default.
- W2062130425 workType "article" @default.