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• W2062133033 abstract "A speculative model is presented that proposes specific mechanisms for effecting co-transcriptional splice site selection in pre-mRNAs. The model envisions that certain splicing factors containing arginine-rich, positively charged regions bind via these positive patches to the hyperphosphorylated, negatively charged tail of elongating RNA polymerase II. Thus tethered to the transcription machinery, these splicing factors gain access to signals in nascent transcripts as they emerge from the polymerase." @default.
• W2062133033 created "2016-06-24" @default.
• W2062133033 creator A5054455401 @default.
• W2062133033 date "1993-04-01" @default.
• W2062133033 modified "2023-09-26" @default.
• W2062133033 title "Positive patches and negative noodles: linking RNA processing to transcription?" @default.
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• W2062133033 doi "https://doi.org/10.1016/0968-0004(93)90016-g" @default.
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