Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062134429> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2062134429 endingPage "1676" @default.
- W2062134429 startingPage "1673" @default.
- W2062134429 abstract "Upon exposure to ionizing radiation, DNA undergoes a variety of modifications including the production of a covalent bond between the nucleobase thymine and the amino acid tyrosine. These crosslinked lesions, produced in cells exposed to ionizing radiation, if unrepaired are thought to result in cell death. We have used electrospray ionization mass spectrometry (ESI-MS) to study a model system consisting of the peptide angiotensin, a 10 amino acid peptide containing only one tyrosine residue, irradiated in the presence of the nucleobase thymine. The presence of the covalently crosslinked species has been determined by ESI-MS, by the appearance of additional species in the irradiated samples which correspond to the adduction of thymine as well as a hydrated species containing thymine and water (5-hydroxy-6-hydrothymine). The formation of 5-hydroxy-6-hydrothymine adduct is reversible and the relative abundance of the thymine and 5-hydroxy-6-hydrothymine adducts is dependent on the pH of the spray solution. High resolution experiments using Fourier transform ion cyclotron resonance mass spectrometry confirms the presence of the thymine and hydrated thymine adducts. The high resolution nature of these experiments also allows the detection of a 5,6-dihydrothymine adduct. © 1997 John Wiley & Sons, Ltd." @default.
- W2062134429 created "2016-06-24" @default.
- W2062134429 creator A5009895356 @default.
- W2062134429 creator A5024407008 @default.
- W2062134429 creator A5036377903 @default.
- W2062134429 creator A5058468399 @default.
- W2062134429 creator A5085384361 @default.
- W2062134429 date "1997-10-15" @default.
- W2062134429 modified "2023-09-26" @default.
- W2062134429 title "Analysis of radiation induced nucleobase-peptide crosslinks by electrospray ionization mass spectrometry" @default.
- W2062134429 doi "https://doi.org/10.1002/(sici)1097-0231(19971015)11:15<1673::aid-rcm38>3.0.co;2-q" @default.
- W2062134429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9364796" @default.
- W2062134429 hasPublicationYear "1997" @default.
- W2062134429 type Work @default.
- W2062134429 sameAs 2062134429 @default.
- W2062134429 citedByCount "6" @default.
- W2062134429 countsByYear W20621344292012 @default.
- W2062134429 countsByYear W20621344292015 @default.
- W2062134429 countsByYear W20621344292019 @default.
- W2062134429 crossrefType "journal-article" @default.
- W2062134429 hasAuthorship W2062134429A5009895356 @default.
- W2062134429 hasAuthorship W2062134429A5024407008 @default.
- W2062134429 hasAuthorship W2062134429A5036377903 @default.
- W2062134429 hasAuthorship W2062134429A5058468399 @default.
- W2062134429 hasAuthorship W2062134429A5085384361 @default.
- W2062134429 hasConcept C108204754 @default.
- W2062134429 hasConcept C162356407 @default.
- W2062134429 hasConcept C170552419 @default.
- W2062134429 hasConcept C178790620 @default.
- W2062134429 hasConcept C180577832 @default.
- W2062134429 hasConcept C185592680 @default.
- W2062134429 hasConcept C2776858809 @default.
- W2062134429 hasConcept C31827203 @default.
- W2062134429 hasConcept C40684141 @default.
- W2062134429 hasConcept C43617362 @default.
- W2062134429 hasConcept C552990157 @default.
- W2062134429 hasConcept C55493867 @default.
- W2062134429 hasConcept C61234307 @default.
- W2062134429 hasConcept C75473681 @default.
- W2062134429 hasConceptScore W2062134429C108204754 @default.
- W2062134429 hasConceptScore W2062134429C162356407 @default.
- W2062134429 hasConceptScore W2062134429C170552419 @default.
- W2062134429 hasConceptScore W2062134429C178790620 @default.
- W2062134429 hasConceptScore W2062134429C180577832 @default.
- W2062134429 hasConceptScore W2062134429C185592680 @default.
- W2062134429 hasConceptScore W2062134429C2776858809 @default.
- W2062134429 hasConceptScore W2062134429C31827203 @default.
- W2062134429 hasConceptScore W2062134429C40684141 @default.
- W2062134429 hasConceptScore W2062134429C43617362 @default.
- W2062134429 hasConceptScore W2062134429C552990157 @default.
- W2062134429 hasConceptScore W2062134429C55493867 @default.
- W2062134429 hasConceptScore W2062134429C61234307 @default.
- W2062134429 hasConceptScore W2062134429C75473681 @default.
- W2062134429 hasIssue "15" @default.
- W2062134429 hasLocation W20621344291 @default.
- W2062134429 hasLocation W20621344292 @default.
- W2062134429 hasOpenAccess W2062134429 @default.
- W2062134429 hasPrimaryLocation W20621344291 @default.
- W2062134429 hasRelatedWork W1502298551 @default.
- W2062134429 hasRelatedWork W1964352867 @default.
- W2062134429 hasRelatedWork W2004645109 @default.
- W2062134429 hasRelatedWork W2007196896 @default.
- W2062134429 hasRelatedWork W2020183931 @default.
- W2062134429 hasRelatedWork W2051858139 @default.
- W2062134429 hasRelatedWork W2052396056 @default.
- W2062134429 hasRelatedWork W2062134429 @default.
- W2062134429 hasRelatedWork W2073147204 @default.
- W2062134429 hasRelatedWork W4239920304 @default.
- W2062134429 hasVolume "11" @default.
- W2062134429 isParatext "false" @default.
- W2062134429 isRetracted "false" @default.
- W2062134429 magId "2062134429" @default.
- W2062134429 workType "article" @default.