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- W2062135785 abstract "This review will highlight recent advances in the understanding of mammalian bombesin receptor-related pathophysiological roles in disease states and new insights into bombesin receptor pharmacology.Studies regarding bombesin-like peptides and mammalian bombesin receptor functions have demonstrated significant biological impact on a broad array of physiological and pathophysiological conditions. Pharmacological experiments in vitro and in vivo as well as utilization of genetic rodent models of the gastrin-releasing peptide receptor (GRP-R/BB2) and neuromedin B receptor (NMB-R/BB1) further delineated roles in memory and fear behavior, inhibition of tumor cell growth, mediating signals for pruritus and male reproductive behavior. All three mammalian bombesin receptors were shown to possess some role in the regulation of energy balance. Novel synthesis of selective high affinity agonists and antagonists of the orphan bombesin receptor subtype-3 (BRS-3/BB3) has been accomplished and will facilitate further studies using animal model systems.Mammalian bombesin receptors participate in the regulation of energy homeostasis and may represent an attractive target for pharmacological treatment of obesity and certain eating disorders. Novel pharmacological insights of bombesin-like peptides and the interaction with their respective receptors have been elucidated to aid future treatment and imaging of epithelial cell-derived tumors." @default.
- W2062135785 created "2016-06-24" @default.
- W2062135785 creator A5021138996 @default.
- W2062135785 creator A5071804000 @default.
- W2062135785 date "2011-02-01" @default.
- W2062135785 modified "2023-09-24" @default.
- W2062135785 title "Biology of mammalian bombesin-like peptides and their receptors" @default.
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- W2062135785 doi "https://doi.org/10.1097/med.0b013e328340ff93" @default.
- W2062135785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21042212" @default.
- W2062135785 hasPublicationYear "2011" @default.
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