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• W2062141655 abstract "The clinical and pathologic findings in 21 patients with hairy cell leukemia (leukemic reticuloendotheliosis) are reviewed. The disease predominantly involved males, and was characterized by a chronic course with an insidious onset and marked splenomegaly. A hypersplenic syndrome with pancytopenia, “hairy cells” in the peripheral blood, and frequent “dry taps” on bone marrow aspiration were common features. Only one patient in this series was leukemic at the onset of disease. Pathologically, the changes in the spleen were distinct from those in other leukemias and malignant lymphomas, and consisted of a diffuse heavy infiltration of the red pulp cords and engorgement of the sinuses by a uniform population of mononuclear cells without mitoses. These cells were not identifiable as either monocytes or lymphocytes, although the pattern of infiltration was more consistent with histiocytic or monocytic than with lymphocytic proliferation. Infiltrates of similar cells were found in the bone marrow, lymph nodes, and livers of many patients early in the course of the disease. Despite this diffuse organ involvement, only 4 patients in this series died, and long survival was common. Splenectomy appeared to be the treatment of choice, whereas vigorous chemotherapy was contraindicated. Accurate diagnosis by recognition of the histologic criteria is therefore essential." @default.
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• W2062141655 date "1974-05-01" @default.
• W2062141655 modified "2023-10-07" @default.
• W2062141655 title "Hairy cell leukemia (leukemic reticuloendotheliosis).I. A clinical pathologic study of 21 patients" @default.
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• W2062141655 doi "https://doi.org/10.1002/1097-0142(197405)33:5<1399::aid-cncr2820330526>3.0.co;2-e" @default.
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