FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062154313> ?p ?o ?g. }

• W2062154313 endingPage "2621" @default.
• W2062154313 startingPage "2608" @default.
• W2062154313 abstract "Abstract Most seed storage proteins of the prolamin class accumulate in the endoplasmic reticulum (ER) as large insoluble polymers termed protein bodies (PBs), through mechanisms that are still poorly understood. We previously showed that a fusion between the Phaseolus vulgaris vacuolar storage protein phaseolin and the N-terminal half of the Zea mays prolamin γ-zein forms ER-located PBs. Zeolin has 6 Cys residues and, like γ-zein with 15 residues, is insoluble unless reduced. The contribution of disulfide bonds to zeolin destiny was determined by studying in vivo the effects of 2-mercaptoethanol (2-ME) and by zeolin mutagenesis. We show that in tobacco (Nicotiana tabacum) protoplasts, 2-ME enhances interactions of newly synthesized proteins with the ER chaperone BiP and inhibits the secretory traffic of soluble proteins with or without disulfide bonds. In spite of this general inhibition, 2-ME enhances the solubility of zeolin and relieves its retention in the ER, resulting in increased zeolin traffic. Consistently, mutated zeolin unable to form disulfide bonds is soluble and efficiently enters the secretory traffic without 2-ME treatment. We conclude that disulfide bonds that lead to insolubilization are a determinant for PB-mediated protein accumulation in the ER." @default.
• W2062154313 created "2016-06-24" @default.
• W2062154313 creator A5070035630 @default.
• W2062154313 creator A5074876307 @default.
• W2062154313 date "2006-10-01" @default.
• W2062154313 modified "2023-09-23" @default.
• W2062154313 title "Retention of a Bean Phaseolin/Maize γ-Zein Fusion in the Endoplasmic Reticulum Depends on Disulfide Bond Formation" @default.
• W2062154313 cites W1429534966 @default.
• W2062154313 cites W1515368650 @default.
• W2062154313 cites W1530972565 @default.
• W2062154313 cites W1576764274 @default.
• W2062154313 cites W1597334704 @default.
• W2062154313 cites W1650842175 @default.
• W2062154313 cites W1844925061 @default.
• W2062154313 cites W1858831003 @default.
• W2062154313 cites W1861594661 @default.
• W2062154313 cites W1971841127 @default.
• W2062154313 cites W1977591524 @default.
• W2062154313 cites W1991213853 @default.
• W2062154313 cites W1992563874 @default.
• W2062154313 cites W1993863965 @default.
• W2062154313 cites W2001225715 @default.
• W2062154313 cites W2009396174 @default.
• W2062154313 cites W2021431752 @default.
• W2062154313 cites W2025865453 @default.
• W2062154313 cites W2025888197 @default.
• W2062154313 cites W2026357888 @default.
• W2062154313 cites W2027082644 @default.
• W2062154313 cites W2030780557 @default.
• W2062154313 cites W2040120486 @default.
• W2062154313 cites W2045039384 @default.
• W2062154313 cites W2062918974 @default.
• W2062154313 cites W2078018592 @default.
• W2062154313 cites W2080802821 @default.
• W2062154313 cites W2083158154 @default.
• W2062154313 cites W2098604934 @default.
• W2062154313 cites W2098941202 @default.
• W2062154313 cites W2099241605 @default.
• W2062154313 cites W2100225528 @default.
• W2062154313 cites W2109464312 @default.
• W2062154313 cites W2116887049 @default.
• W2062154313 cites W2121663459 @default.
• W2062154313 cites W2126438686 @default.
• W2062154313 cites W2129462035 @default.
• W2062154313 cites W2137793003 @default.
• W2062154313 cites W2142519956 @default.
• W2062154313 cites W2150687566 @default.
• W2062154313 cites W2152170501 @default.
• W2062154313 cites W2154255482 @default.
• W2062154313 cites W2160513335 @default.
• W2062154313 cites W2161529012 @default.
• W2062154313 cites W2166512362 @default.
• W2062154313 cites W2182013323 @default.
• W2062154313 cites W2192080449 @default.
• W2062154313 cites W22275465 @default.
• W2062154313 cites W239092166 @default.
• W2062154313 cites W4233248805 @default.
• W2062154313 cites W4300702414 @default.
• W2062154313 doi "https://doi.org/10.1105/tpc.106.042226" @default.
• W2062154313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1626613" @default.
• W2062154313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17041149" @default.
• W2062154313 hasPublicationYear "2006" @default.
• W2062154313 type Work @default.
• W2062154313 sameAs 2062154313 @default.
• W2062154313 citedByCount "52" @default.
• W2062154313 countsByYear W20621543132012 @default.
• W2062154313 countsByYear W20621543132013 @default.
• W2062154313 countsByYear W20621543132014 @default.
• W2062154313 countsByYear W20621543132015 @default.
• W2062154313 countsByYear W20621543132016 @default.
• W2062154313 countsByYear W20621543132017 @default.
• W2062154313 countsByYear W20621543132018 @default.
• W2062154313 countsByYear W20621543132019 @default.
• W2062154313 countsByYear W20621543132021 @default.
• W2062154313 crossrefType "journal-article" @default.
• W2062154313 hasAuthorship W2062154313A5070035630 @default.
• W2062154313 hasAuthorship W2062154313A5074876307 @default.
• W2062154313 hasBestOaLocation W20621543131 @default.
• W2062154313 hasConcept C104317684 @default.
• W2062154313 hasConcept C123894998 @default.
• W2062154313 hasConcept C12554922 @default.
• W2062154313 hasConcept C143065580 @default.
• W2062154313 hasConcept C156399914 @default.
• W2062154313 hasConcept C158617107 @default.
• W2062154313 hasConcept C181199279 @default.
• W2062154313 hasConcept C2778043179 @default.
• W2062154313 hasConcept C2779201268 @default.
• W2062154313 hasConcept C2780165273 @default.
• W2062154313 hasConcept C2781205006 @default.
• W2062154313 hasConcept C40767141 @default.
• W2062154313 hasConcept C49039625 @default.
• W2062154313 hasConcept C5098756 @default.
• W2062154313 hasConcept C55493867 @default.
• W2062154313 hasConcept C86803240 @default.
• W2062154313 hasConcept C95444343 @default.
• W2062154313 hasConcept C97564808 @default.
• W2062154313 hasConceptScore W2062154313C104317684 @default.
• W2062154313 hasConceptScore W2062154313C123894998 @default.

• next