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• W2062164192 abstract "The present studies were designed to determine whether an ultrashort loop feedback mechanism is involved in the regulation of LHRH secretion. Daily administration of a highly potent LHRH agonist (LHRH-AGO; [D-Ala6,Des-Gly10] LHRH ethylamide) immediately after orchidectomy (ORDX) significantly attenuated the rise of plasma LH from days 2 through 10 after ORDX. Concomitantly with the diminished LH rise after ORDX, a significant increase in LHRH content in the arcuate nucleus was observed in LHRH-AGO-treated rats. Measurement of LHRH levels in hypophyseal portal blood in rats 10 days after ORDX combined with daily agonist treatment revealed a significant decrease in LHRH values in portal plasma compared with those in orchidectomized controls. Arcuate nuclei- median eminence (ME) fragments obtained from ORDX rats treated in vivo with LHRH-AGO for 5 days showed a decreased basal secretion of LHRH and a diminished response to K+ stimulation compared with the release from fragments obtained from ORDX saline-treated controls. To evaluate whether a tonic LHRH inhibitory activity operates within the ME, additional experiments were performed in which ME fragments were incubated in vitro in the presence of a potent LHRH antagonist ([D-pGlu1D-Phe2D-Trp3,6JLHRH). The antagonist significantly enhanced the basal secretion of LHRHJn-a-dose tiependenf manner. The latter results suggest that LHRH antagonists-may enhance LHRH rolcaoo, perhaps by interacting with LHRH receptors-playing an inhibitory role on the endogenous secretion of the decapeptide. These observations strongly suggest a tonic inhibitory or modulatory role of LHRH neurons in the regulation of their own function. (Endocrinology121: 2256–2259, 1987)" @default.
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• W2062164192 date "1987-12-01" @default.
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• W2062164192 title "Evidence for a Negative Ultrashort Loop Feedback Mechanism Operating on the Luteinizing Hormone-Releasing Hormone Neuronal System" @default.
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• W2062164192 doi "https://doi.org/10.1210/endo-121-6-2256" @default.
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