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- W2062174927 abstract "The α-2-adrenoreceptor agonist clonidine increases growth-hormone secretion in healthy controls after intravenous injection. 1 Thomaides TN Chaudhuri KR Maule S Watson L Marsden CD Mathias CJ Growth hormone response to clonidine in central and peripheral primary autonomic failure. Lancet. 1992; 340: 263-266 Summary PubMed Scopus (43) Google Scholar This response also occurs in patients suffering from pure autonomic failure, but is absent in those with multiple system atrophy (MSA) who are thought to have a central rather than a peripheral autonomic deficit. Previously in The Lancet. Kimber and colleagues 2 Kimber JR Watson L Mathias CJ Distinction of idiopathic Parkinson's disease from multiple-system atrophy by stimulation of growth hormone release with clonidine. Lancet. 1997; 349: 1877-1881 Summary Full Text Full Text PDF PubMed Scopus (117) Google Scholar showed that growth-hormone levels increase in untreated patients with a clinical diagnosis of idiopathic Parkinson's disease (IPD), raising the possibility that this response may form the basis of a diagnostic test to differentiate MSA from IPD. We used their methodology to compare the growth-hormone response to intravenous clonidine in patients with MSA, early untreated IPD, and later levodopa-treated IPD." @default.
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- W2062174927 date "1999-04-01" @default.
- W2062174927 modified "2023-10-13" @default.
- W2062174927 title "Failure of the clonidine growth hormone stimulation test to differentiate multiple system atrophy from early or advanced idiopathic Parkinson's disease" @default.
- W2062174927 cites W1973644561 @default.
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- W2062174927 doi "https://doi.org/10.1016/s0140-6736(99)00147-6" @default.
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