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• W2062175712 endingPage "172" @default.
• W2062175712 startingPage "167" @default.
• W2062175712 abstract "Camptothecin-based drugs, because of their poor solubility and labile lactone ring, pose challenges for drug delivery. The purpose of this research was to develop a nanoparticle delivery system for camptotheca alkaloids. After initial investigations SN-38 was selected as the candidate camptotheca alkaloid for further development. Nanoparticles comprising SN-38, phospholipids and polyethylene glycol were developed and studied in vitro and in vivo. The SN-38 formulations were stable in human serum albumin and high lactone concentrations were observed even after 3 h. In vivo studies in nude mice showed prolonged half-life of the active (lactone form) drug in whole blood and increased efficacy compared to Camptosar in a mouse xenograft tumor model." @default.
• W2062175712 created "2016-06-24" @default.
• W2062175712 creator A5023739438 @default.
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• W2062175712 date "2003-08-28" @default.
• W2062175712 modified "2023-10-17" @default.
• W2062175712 title "Nanoparticle drug delivery system for intravenous delivery of topoisomerase inhibitors" @default.
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• W2062175712 doi "https://doi.org/10.1016/s0168-3659(03)00241-4" @default.
• W2062175712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12932648" @default.
• W2062175712 hasPublicationYear "2003" @default.
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