FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062179663> ?p ?o ?g. }

• W2062179663 endingPage "1110" @default.
• W2062179663 startingPage "1103" @default.
• W2062179663 abstract "The aim of this study was to evaluate the links between connexin43 (Cx43) expression, myocardial conduction velocity, and ventricular tachycardia in a model of healed myocardial infarction.Post-infarction ventricular arrhythmias frequently cause sudden death. Impaired myocardial conduction has previously been linked to ventricular arrhythmias. Altered connexin expression is a potential source of conduction slowing identified in healed scar border tissues. The functional effect of increasing border-zone Cx43 has not been previously evaluated.Twenty-five Yorkshire pigs underwent anterior infarction by transient left anterior descending coronary artery occlusion, followed by weekly testing for arrhythmia inducibility. Twenty animals with reproducibly inducible sustained monomorphic ventricular tachycardia were randomized 2:1:1 to receive AdCx43, Adβgal, or no gene transfer. One week later, animals underwent follow-up electrophysiologic study and tissue assessment for several functional and molecular measures.Animals receiving AdCx43 had less electrogram fractionation and faster conduction velocity in the anterior-septal border zone. Only 40% of AdCx43 animals remained inducible for ventricular tachycardia, while 100% of controls were inducible after gene transfer. AdCx43 animals had 2-fold higher Cx43 protein levels in the anterior-septal infarct border, with similar percents of phosphorylated and intercalated disk-localized Cx43 compared with controls.These data mechanistically link Cx43 expression to slow conduction and arrhythmia susceptibility in the healed scar border zone. Targeted manipulation of Cx43 levels improved conduction velocity and reduced ventricular tachycardia susceptibility. Cx43 gene transfer represents a novel treatment strategy for post-infarction arrhythmias." @default.
• W2062179663 created "2016-06-24" @default.
• W2062179663 creator A5003276173 @default.
• W2062179663 creator A5017656462 @default.
• W2062179663 creator A5038576548 @default.
• W2062179663 creator A5050624019 @default.
• W2062179663 creator A5062482097 @default.
• W2062179663 creator A5064015226 @default.
• W2062179663 creator A5065844265 @default.
• W2062179663 date "2012-09-01" @default.
• W2062179663 modified "2023-10-05" @default.
• W2062179663 title "Connexin43 Gene Transfer Reduces Ventricular Tachycardia Susceptibility After Myocardial Infarction" @default.
• W2062179663 cites W1559427936 @default.
• W2062179663 cites W1967794787 @default.
• W2062179663 cites W1977859104 @default.
• W2062179663 cites W1985376688 @default.
• W2062179663 cites W1986096604 @default.
• W2062179663 cites W1990076948 @default.
• W2062179663 cites W1994800264 @default.
• W2062179663 cites W2001407497 @default.
• W2062179663 cites W2001718347 @default.
• W2062179663 cites W2005752917 @default.
• W2062179663 cites W2030916531 @default.
• W2062179663 cites W2035105244 @default.
• W2062179663 cites W2039011843 @default.
• W2062179663 cites W2056493589 @default.
• W2062179663 cites W2062701917 @default.
• W2062179663 cites W2070722083 @default.
• W2062179663 cites W2072599899 @default.
• W2062179663 cites W2076443361 @default.
• W2062179663 cites W2092858826 @default.
• W2062179663 cites W2093705028 @default.
• W2062179663 cites W2097205940 @default.
• W2062179663 cites W2098276166 @default.
• W2062179663 cites W2105882710 @default.
• W2062179663 cites W2128296661 @default.
• W2062179663 cites W2134982681 @default.
• W2062179663 cites W2154306328 @default.
• W2062179663 cites W2156349785 @default.
• W2062179663 cites W2158152768 @default.
• W2062179663 cites W2159393887 @default.
• W2062179663 cites W2341968681 @default.
• W2062179663 doi "https://doi.org/10.1016/j.jacc.2012.04.042" @default.
• W2062179663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3578694" @default.
• W2062179663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22883636" @default.
• W2062179663 hasPublicationYear "2012" @default.
• W2062179663 type Work @default.
• W2062179663 sameAs 2062179663 @default.
• W2062179663 citedByCount "92" @default.
• W2062179663 countsByYear W20621796632012 @default.
• W2062179663 countsByYear W20621796632013 @default.
• W2062179663 countsByYear W20621796632014 @default.
• W2062179663 countsByYear W20621796632015 @default.
• W2062179663 countsByYear W20621796632016 @default.
• W2062179663 countsByYear W20621796632017 @default.
• W2062179663 countsByYear W20621796632018 @default.
• W2062179663 countsByYear W20621796632019 @default.
• W2062179663 countsByYear W20621796632020 @default.
• W2062179663 countsByYear W20621796632021 @default.
• W2062179663 countsByYear W20621796632022 @default.
• W2062179663 countsByYear W20621796632023 @default.
• W2062179663 crossrefType "journal-article" @default.
• W2062179663 hasAuthorship W2062179663A5003276173 @default.
• W2062179663 hasAuthorship W2062179663A5017656462 @default.
• W2062179663 hasAuthorship W2062179663A5038576548 @default.
• W2062179663 hasAuthorship W2062179663A5050624019 @default.
• W2062179663 hasAuthorship W2062179663A5062482097 @default.
• W2062179663 hasAuthorship W2062179663A5064015226 @default.
• W2062179663 hasAuthorship W2062179663A5065844265 @default.
• W2062179663 hasBestOaLocation W20621796631 @default.
• W2062179663 hasConcept C126322002 @default.
• W2062179663 hasConcept C158157758 @default.
• W2062179663 hasConcept C164705383 @default.
• W2062179663 hasConcept C179253579 @default.
• W2062179663 hasConcept C2776331378 @default.
• W2062179663 hasConcept C2777798775 @default.
• W2062179663 hasConcept C2780228694 @default.
• W2062179663 hasConcept C2780283014 @default.
• W2062179663 hasConcept C500558357 @default.
• W2062179663 hasConcept C71924100 @default.
• W2062179663 hasConcept C79879829 @default.
• W2062179663 hasConcept C86803240 @default.
• W2062179663 hasConcept C95444343 @default.
• W2062179663 hasConceptScore W2062179663C126322002 @default.
• W2062179663 hasConceptScore W2062179663C158157758 @default.
• W2062179663 hasConceptScore W2062179663C164705383 @default.
• W2062179663 hasConceptScore W2062179663C179253579 @default.
• W2062179663 hasConceptScore W2062179663C2776331378 @default.
• W2062179663 hasConceptScore W2062179663C2777798775 @default.
• W2062179663 hasConceptScore W2062179663C2780228694 @default.
• W2062179663 hasConceptScore W2062179663C2780283014 @default.
• W2062179663 hasConceptScore W2062179663C500558357 @default.
• W2062179663 hasConceptScore W2062179663C71924100 @default.
• W2062179663 hasConceptScore W2062179663C79879829 @default.
• W2062179663 hasConceptScore W2062179663C86803240 @default.
• W2062179663 hasConceptScore W2062179663C95444343 @default.
• W2062179663 hasFunder F4320332161 @default.
• W2062179663 hasFunder F4320332389 @default.

• next