FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062183712> ?p ?o ?g. }

• W2062183712 endingPage "1213" @default.
• W2062183712 startingPage "1213" @default.
• W2062183712 abstract "Combined use of systemic agents may be necessary to achieve disease control in therapy-resistant patients. However, to our knowledge, an overview of evidence, including quality assessments, is not yet available, and no guidance on monitoring, contraindications, and interactions exists.To summarize and critically appraise the evidence on efficacy and safety of combination therapy with systemic agents in plaque-type psoriasis.Through March 2013, an electronic search limited to randomized clinical trials was performed in MEDLINE, EMBASE, The Cochrane Library, and ongoing trial registers. The quality of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation approach.The initial search retrieved 2583 records, of which 17 met the inclusion criteria. Most studies favored combination therapy, albeit with low significance and low quality of evidence. Etanercept plus methotrexate was the only combination therapy investigated with an adequate sample size (n = 478). In the short term, this combination had superior efficacy with a moderate quality of evidence compared with etanercept monotherapy (Psoriasis Area and Severity Index, 75; relative risk, 1.28; 95% CI, 1.14-1.45). Although this finding coincided with an increase in adverse events (relative risk, 1.25; 95% CI, 1.10-1.42), the overall safety profile remained acceptable.This systematic review provides a comprehensive overview on the validity of different systemic combination therapies. For most combinations, insufficient evidence is available. Initial results indicate that combined therapy with etanercept plus methotrexate may be beneficial in patients that are therapy resistant under intensive follow-up. Dose reductions should be taken into account to minimize adverse effects." @default.
• W2062183712 created "2016-06-24" @default.
• W2062183712 creator A5017213436 @default.
• W2062183712 creator A5059454433 @default.
• W2062183712 creator A5071748458 @default.
• W2062183712 creator A5072786878 @default.
• W2062183712 creator A5079104899 @default.
• W2062183712 date "2014-11-01" @default.
• W2062183712 modified "2023-09-27" @default.
• W2062183712 title "Combined Use of Systemic Agents for Psoriasis" @default.
• W2062183712 cites W1512309538 @default.
• W2062183712 cites W1552422862 @default.
• W2062183712 cites W1591809044 @default.
• W2062183712 cites W1892332642 @default.
• W2062183712 cites W1964871328 @default.
• W2062183712 cites W1968637637 @default.
• W2062183712 cites W1976162606 @default.
• W2062183712 cites W1988729643 @default.
• W2062183712 cites W1996656260 @default.
• W2062183712 cites W1996773947 @default.
• W2062183712 cites W1999805761 @default.
• W2062183712 cites W2024261468 @default.
• W2062183712 cites W2027619293 @default.
• W2062183712 cites W2029474929 @default.
• W2062183712 cites W2031762699 @default.
• W2062183712 cites W2033997495 @default.
• W2062183712 cites W2050849983 @default.
• W2062183712 cites W2052065030 @default.
• W2062183712 cites W2056765274 @default.
• W2062183712 cites W2063379728 @default.
• W2062183712 cites W2069350424 @default.
• W2062183712 cites W2090132603 @default.
• W2062183712 cites W2091442391 @default.
• W2062183712 cites W2097935815 @default.
• W2062183712 cites W2104866882 @default.
• W2062183712 cites W2107036705 @default.
• W2062183712 cites W2110441300 @default.
• W2062183712 cites W2134048257 @default.
• W2062183712 cites W2146843653 @default.
• W2062183712 cites W2154312718 @default.
• W2062183712 cites W2164533070 @default.
• W2062183712 cites W2165010366 @default.
• W2062183712 cites W2236095340 @default.
• W2062183712 cites W2475329425 @default.
• W2062183712 doi "https://doi.org/10.1001/jamadermatol.2014.1111" @default.
• W2062183712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25188393" @default.
• W2062183712 hasPublicationYear "2014" @default.
• W2062183712 type Work @default.
• W2062183712 sameAs 2062183712 @default.
• W2062183712 citedByCount "32" @default.
• W2062183712 countsByYear W20621837122015 @default.
• W2062183712 countsByYear W20621837122016 @default.
• W2062183712 countsByYear W20621837122017 @default.
• W2062183712 countsByYear W20621837122018 @default.
• W2062183712 countsByYear W20621837122019 @default.
• W2062183712 countsByYear W20621837122020 @default.
• W2062183712 countsByYear W20621837122021 @default.
• W2062183712 countsByYear W20621837122022 @default.
• W2062183712 countsByYear W20621837122023 @default.
• W2062183712 crossrefType "journal-article" @default.
• W2062183712 hasAuthorship W2062183712A5017213436 @default.
• W2062183712 hasAuthorship W2062183712A5059454433 @default.
• W2062183712 hasAuthorship W2062183712A5071748458 @default.
• W2062183712 hasAuthorship W2062183712A5072786878 @default.
• W2062183712 hasAuthorship W2062183712A5079104899 @default.
• W2062183712 hasConcept C121608353 @default.
• W2062183712 hasConcept C126322002 @default.
• W2062183712 hasConcept C16005928 @default.
• W2062183712 hasConcept C168563851 @default.
• W2062183712 hasConcept C17744445 @default.
• W2062183712 hasConcept C177713679 @default.
• W2062183712 hasConcept C185926286 @default.
• W2062183712 hasConcept C197934379 @default.
• W2062183712 hasConcept C199539241 @default.
• W2062183712 hasConcept C2776478404 @default.
• W2062183712 hasConcept C2776999253 @default.
• W2062183712 hasConcept C2777011040 @default.
• W2062183712 hasConcept C2777226972 @default.
• W2062183712 hasConcept C2777575956 @default.
• W2062183712 hasConcept C2779473830 @default.
• W2062183712 hasConcept C2780564577 @default.
• W2062183712 hasConcept C2781059491 @default.
• W2062183712 hasConcept C530470458 @default.
• W2062183712 hasConcept C71924100 @default.
• W2062183712 hasConcept C95190672 @default.
• W2062183712 hasConceptScore W2062183712C121608353 @default.
• W2062183712 hasConceptScore W2062183712C126322002 @default.
• W2062183712 hasConceptScore W2062183712C16005928 @default.
• W2062183712 hasConceptScore W2062183712C168563851 @default.
• W2062183712 hasConceptScore W2062183712C17744445 @default.
• W2062183712 hasConceptScore W2062183712C177713679 @default.
• W2062183712 hasConceptScore W2062183712C185926286 @default.
• W2062183712 hasConceptScore W2062183712C197934379 @default.
• W2062183712 hasConceptScore W2062183712C199539241 @default.
• W2062183712 hasConceptScore W2062183712C2776478404 @default.
• W2062183712 hasConceptScore W2062183712C2776999253 @default.
• W2062183712 hasConceptScore W2062183712C2777011040 @default.
• W2062183712 hasConceptScore W2062183712C2777226972 @default.

• next