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- W2062206599 abstract "Rat everted jejunal sacs were incubated for 15 and 30 min at 37oC in oxygenated Krebs-Henseleit buffer, pH 7.4, containing 0.2 μm [3H]-thiamin (3H-T) or [3H]-thiamin monophosphate (3H-TMP) with and without 10 him 1-phenylalanine (PAL) or 2.5 mM levamisole (LEV). The concentrations of 3H-T and its phosphoesters in sac wall and serosal fluid were determined by a radiometric method after electrophoretic separation. In separate experiments, thiamin pyrophosphokinase (TPKase) and thiamin pyrophosphatase (TPPase) activities were determined in mucosal scrapings, with and without PAL or LEV, by using a radiometric and a colorimetric method, respectively. 3H-TMP was transported partly unchanged by an active mechanism similarly to 3H-T, but less efficiently. During transport, 3H-TMP was also enzymatical-ly transformed to thiamin (T) and thiamin pyrophosphate, which accumulated in the tissue. In the serosal fluid, the concentration of 3H-TMP exceeded that of 3H-T. Presence of PAL or LEV with 3H-T or 3H-TMP in the incubation medium reduced the serosal transport and the tissue content of T compounds. LEV caused a dose-dependent inhibition of TPKase without affecting TPPase, whereas PAL inhibited both activities to about the same extent. These results indicate that the transport of TMP involves a number of different processes similar to those resposible for T transport. The effects of PAL and LEV underline the importance of phosphorylation-dephosphorylation coupling." @default.
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- W2062206599 date "1988-01-01" @default.
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- W2062206599 title "Intestinal transport of thiamin and thiamin monophosphate in rat everted jejunal sacs: A comparative study using some potential inhibitors" @default.
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- W2062206599 doi "https://doi.org/10.3109/13813458809075947" @default.
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