FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062206844> ?p ?o ?g. }

• W2062206844 endingPage "332" @default.
• W2062206844 startingPage "320" @default.
• W2062206844 abstract "Toward our goal to better understand the physiological parameters that mediate olfactory information processing on the cellular level, voltage-activated calcium currents ( I Ca ) in olfactory interneurons of the antennal lobe from adult cockroaches were analyzed under two conditions: 1) in acutely dissociated cells (in vitro) and 2) in an intact brain preparation (in situ). The study included an analysis of modulatory effects of potential inorganic and organic Ca 2+ channel blockers. I Ca was isolated and identified using pharmacological, voltage, and ion substitution protocols. I Ca consisted of two components: transient and sustained. The decay of the transient component was largely Ca 2+ dependent. In vitro, I Ca had an activation threshold of −50 mV with a maximal peak current at −7 mV and a half-maximal voltage ( V 0.5act ) for tail-current activation of −18 mV. In situ these parameters were significantly shifted to more depolarized membrane potentials: I Ca activated at −40 mV with a maximal peak current at 8 mV and a V 0.5act for tail-current activation of −11 mV. The sensitivity of I Ca to the divalent cations Cd 2+ , Co 2+ , and Ni 2+ was dose dependent. The most effective blocker was Cd 2+ with an IC 50 of 10 −5 M followed by Ni 2+ (IC 50 = 3.13 × 10 −3 M) and Co 2+ (IC 50 = 1.06 × 10 −3 M). The organic channel blockers verapamil, diltiazem, and nifedipine also blocked I Ca in a dose-dependent way and had differential effects on the current waveform. Verapamil blocked I Ca with an IC 50 of 1.5 × 10 −4 M and diltiazem had an IC 50 of 2.87 × 10 −4 M. Nifedipine blocked I Ca by 33% at a concentration of 10 −4 M." @default.
• W2062206844 created "2016-06-24" @default.
• W2062206844 creator A5001454840 @default.
• W2062206844 creator A5011000817 @default.
• W2062206844 creator A5078503461 @default.
• W2062206844 date "2008-01-01" @default.
• W2062206844 modified "2023-10-18" @default.
• W2062206844 title "Functional Parameters of Voltage-Activated Ca²⁺Currents From Olfactory Interneurons in the Antennal Lobe of<i>Periplaneta americana</i>" @default.
• W2062206844 cites W1556321065 @default.
• W2062206844 cites W1559513285 @default.
• W2062206844 cites W1561818412 @default.
• W2062206844 cites W1622707836 @default.
• W2062206844 cites W1736882089 @default.
• W2062206844 cites W1919066930 @default.
• W2062206844 cites W1971571359 @default.
• W2062206844 cites W1983423336 @default.
• W2062206844 cites W1987794083 @default.
• W2062206844 cites W1999122587 @default.
• W2062206844 cites W2001541852 @default.
• W2062206844 cites W2009667219 @default.
• W2062206844 cites W2022790467 @default.
• W2062206844 cites W2024986782 @default.
• W2062206844 cites W2025658697 @default.
• W2062206844 cites W2026117899 @default.
• W2062206844 cites W2030966306 @default.
• W2062206844 cites W2035198661 @default.
• W2062206844 cites W2037761688 @default.
• W2062206844 cites W2041440424 @default.
• W2062206844 cites W2057761743 @default.
• W2062206844 cites W2060071323 @default.
• W2062206844 cites W2089491131 @default.
• W2062206844 cites W2094541430 @default.
• W2062206844 cites W2098468977 @default.
• W2062206844 cites W2100548210 @default.
• W2062206844 cites W2108369925 @default.
• W2062206844 cites W2115052737 @default.
• W2062206844 cites W2116695741 @default.
• W2062206844 cites W2123847061 @default.
• W2062206844 cites W2129706672 @default.
• W2062206844 cites W2146084177 @default.
• W2062206844 cites W2147577444 @default.
• W2062206844 cites W2161496609 @default.
• W2062206844 cites W2166037344 @default.
• W2062206844 cites W2168899587 @default.
• W2062206844 cites W2170271247 @default.
• W2062206844 cites W2170723389 @default.
• W2062206844 cites W2172000772 @default.
• W2062206844 cites W2187230393 @default.
• W2062206844 cites W2189178028 @default.
• W2062206844 cites W2201690143 @default.
• W2062206844 cites W2246750910 @default.
• W2062206844 cites W2266895802 @default.
• W2062206844 cites W2281958880 @default.
• W2062206844 cites W2337804182 @default.
• W2062206844 cites W2339840852 @default.
• W2062206844 cites W2395419152 @default.
• W2062206844 cites W2407259968 @default.
• W2062206844 cites W2419070418 @default.
• W2062206844 cites W2420071848 @default.
• W2062206844 cites W2439160244 @default.
• W2062206844 cites W2442517266 @default.
• W2062206844 cites W2912991414 @default.
• W2062206844 doi "https://doi.org/10.1152/jn.00719.2007" @default.
• W2062206844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18003883" @default.
• W2062206844 hasPublicationYear "2008" @default.
• W2062206844 type Work @default.
• W2062206844 sameAs 2062206844 @default.
• W2062206844 citedByCount "16" @default.
• W2062206844 countsByYear W20622068442012 @default.
• W2062206844 countsByYear W20622068442015 @default.
• W2062206844 countsByYear W20622068442016 @default.
• W2062206844 countsByYear W20622068442017 @default.
• W2062206844 countsByYear W20622068442021 @default.
• W2062206844 countsByYear W20622068442022 @default.
• W2062206844 crossrefType "journal-article" @default.
• W2062206844 hasAuthorship W2062206844A5001454840 @default.
• W2062206844 hasAuthorship W2062206844A5011000817 @default.
• W2062206844 hasAuthorship W2062206844A5078503461 @default.
• W2062206844 hasConcept C12554922 @default.
• W2062206844 hasConcept C153461711 @default.
• W2062206844 hasConcept C169760540 @default.
• W2062206844 hasConcept C178790620 @default.
• W2062206844 hasConcept C181911157 @default.
• W2062206844 hasConcept C185263204 @default.
• W2062206844 hasConcept C185592680 @default.
• W2062206844 hasConcept C18699975 @default.
• W2062206844 hasConcept C18903297 @default.
• W2062206844 hasConcept C2777022698 @default.
• W2062206844 hasConcept C2777346155 @default.
• W2062206844 hasConcept C2780625307 @default.
• W2062206844 hasConcept C519063684 @default.
• W2062206844 hasConcept C55493867 @default.
• W2062206844 hasConcept C74884574 @default.
• W2062206844 hasConcept C86803240 @default.
• W2062206844 hasConceptScore W2062206844C12554922 @default.
• W2062206844 hasConceptScore W2062206844C153461711 @default.
• W2062206844 hasConceptScore W2062206844C169760540 @default.
• W2062206844 hasConceptScore W2062206844C178790620 @default.

• next