Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062211967> ?p ?o ?g. }
- W2062211967 endingPage "256" @default.
- W2062211967 startingPage "249" @default.
- W2062211967 abstract "We examined potential maternal-fetal interactions during fetal cardiopulmonary bypass. these interactions, not previously described, may significantly influence attempts at fetal cardiac surgery.Eight fetal sheep underwent cardiopulmonary bypass (5 singletons, 3 twins; 100-109 days) for 60 minutes using a centrifugal microcircuit (20 mL prime), and the placenta as oxygenator. We measured maternal hemodynamics, arterial blood gases, and changes in blood flow to the gravid uterus using bilateral uterine artery flow probes. Maternal measurements were correlated to fetal hemodynamics, blood gases, and umbilical blood flows. After bypass, fetuses were followed for 60 minutes.Decreases in uterine blood flow occurred without changes in maternal hemodynamics or arterial blood gases, but were associated with worsening fetal arterial blood gases (pH decreased from 7.2 +/- 0.2 to 7.0 +/- 0.1, partial pressure of carbon dioxide increased 45.6% and partial pressure of oxygen decreased 15.4%). Changes in maternal hemodynamics (decreased systolic blood pressure [17.5%, SD = 11] and decreased diastolic blood pressure [20.3%, SD = 15]) were only noted when uterine blood flows decreased by greater than 38.2% (SD = 26). Correction of maternal hypocalcemia (0.89 g/dL, SD = 0.1) led to improved uterine artery flows (28.3% increase, SD = 30). Finally, fetal sternotomy, cannulation, and cardiopulmonary bypass each decreased uterine artery flows by 27.5% (SD = 18), 31.0% (SD = 26), and 39.7% (SD = 25), respectively. Similar changes were not observed in the nonbypass twin.Significant changes in uterine blood flow can occur during fetal cardiopulmonary bypass support without apparent changes in maternal hemodynamics or arterial blood gases. These changes imply a unique transplacental maternal-fetal interaction. Limited data from the twin fetus suggest a localized mechanism involving only the segment of placenta exposed to extracorporeal circulation." @default.
- W2062211967 created "2016-06-24" @default.
- W2062211967 creator A5001549231 @default.
- W2062211967 creator A5013318922 @default.
- W2062211967 creator A5042095567 @default.
- W2062211967 creator A5044013497 @default.
- W2062211967 creator A5048204132 @default.
- W2062211967 creator A5048867312 @default.
- W2062211967 creator A5066803227 @default.
- W2062211967 creator A5082447783 @default.
- W2062211967 creator A5089902417 @default.
- W2062211967 date "2006-01-01" @default.
- W2062211967 modified "2023-10-14" @default.
- W2062211967 title "Maternal-Fetal Interactions in Fetal Cardiac Surgery" @default.
- W2062211967 cites W1849371130 @default.
- W2062211967 cites W1870890372 @default.
- W2062211967 cites W1947755567 @default.
- W2062211967 cites W1971606324 @default.
- W2062211967 cites W1982095384 @default.
- W2062211967 cites W1987082578 @default.
- W2062211967 cites W1990465696 @default.
- W2062211967 cites W1993396125 @default.
- W2062211967 cites W1995942926 @default.
- W2062211967 cites W1996852327 @default.
- W2062211967 cites W1999736429 @default.
- W2062211967 cites W2011732429 @default.
- W2062211967 cites W2022978440 @default.
- W2062211967 cites W2029283160 @default.
- W2062211967 cites W2037436738 @default.
- W2062211967 cites W2048294393 @default.
- W2062211967 cites W2050868673 @default.
- W2062211967 cites W2064273276 @default.
- W2062211967 cites W2065477524 @default.
- W2062211967 cites W2066580637 @default.
- W2062211967 cites W2069296756 @default.
- W2062211967 cites W2082489040 @default.
- W2062211967 cites W2082710058 @default.
- W2062211967 cites W2102115309 @default.
- W2062211967 cites W2159569724 @default.
- W2062211967 cites W2167950650 @default.
- W2062211967 cites W2322242102 @default.
- W2062211967 cites W2323737086 @default.
- W2062211967 cites W2398845196 @default.
- W2062211967 cites W2404394801 @default.
- W2062211967 cites W2509613728 @default.
- W2062211967 doi "https://doi.org/10.1016/j.athoracsur.2005.06.053" @default.
- W2062211967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16368376" @default.
- W2062211967 hasPublicationYear "2006" @default.
- W2062211967 type Work @default.
- W2062211967 sameAs 2062211967 @default.
- W2062211967 citedByCount "17" @default.
- W2062211967 countsByYear W20622119672013 @default.
- W2062211967 countsByYear W20622119672015 @default.
- W2062211967 countsByYear W20622119672016 @default.
- W2062211967 countsByYear W20622119672023 @default.
- W2062211967 crossrefType "journal-article" @default.
- W2062211967 hasAuthorship W2062211967A5001549231 @default.
- W2062211967 hasAuthorship W2062211967A5013318922 @default.
- W2062211967 hasAuthorship W2062211967A5042095567 @default.
- W2062211967 hasAuthorship W2062211967A5044013497 @default.
- W2062211967 hasAuthorship W2062211967A5048204132 @default.
- W2062211967 hasAuthorship W2062211967A5048867312 @default.
- W2062211967 hasAuthorship W2062211967A5066803227 @default.
- W2062211967 hasAuthorship W2062211967A5082447783 @default.
- W2062211967 hasAuthorship W2062211967A5089902417 @default.
- W2062211967 hasBestOaLocation W20622119671 @default.
- W2062211967 hasConcept C126322002 @default.
- W2062211967 hasConcept C158846371 @default.
- W2062211967 hasConcept C164705383 @default.
- W2062211967 hasConcept C172680121 @default.
- W2062211967 hasConcept C178853913 @default.
- W2062211967 hasConcept C2776820930 @default.
- W2062211967 hasConcept C2778881276 @default.
- W2062211967 hasConcept C2779234561 @default.
- W2062211967 hasConcept C2780820407 @default.
- W2062211967 hasConcept C2781207646 @default.
- W2062211967 hasConcept C42219234 @default.
- W2062211967 hasConcept C46973012 @default.
- W2062211967 hasConcept C54355233 @default.
- W2062211967 hasConcept C71924100 @default.
- W2062211967 hasConcept C84393581 @default.
- W2062211967 hasConcept C86803240 @default.
- W2062211967 hasConceptScore W2062211967C126322002 @default.
- W2062211967 hasConceptScore W2062211967C158846371 @default.
- W2062211967 hasConceptScore W2062211967C164705383 @default.
- W2062211967 hasConceptScore W2062211967C172680121 @default.
- W2062211967 hasConceptScore W2062211967C178853913 @default.
- W2062211967 hasConceptScore W2062211967C2776820930 @default.
- W2062211967 hasConceptScore W2062211967C2778881276 @default.
- W2062211967 hasConceptScore W2062211967C2779234561 @default.
- W2062211967 hasConceptScore W2062211967C2780820407 @default.
- W2062211967 hasConceptScore W2062211967C2781207646 @default.
- W2062211967 hasConceptScore W2062211967C42219234 @default.
- W2062211967 hasConceptScore W2062211967C46973012 @default.
- W2062211967 hasConceptScore W2062211967C54355233 @default.
- W2062211967 hasConceptScore W2062211967C71924100 @default.
- W2062211967 hasConceptScore W2062211967C84393581 @default.
- W2062211967 hasConceptScore W2062211967C86803240 @default.