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• W2062213947 abstract "A rise in the intracellular calcium (Ca2+) concentration is a major component of the signaling mechanisms regulating platelet function in thrombosis and hemostasis. Previous studies, however, failed to identify many key molecules regulating Ca2+ signaling in platelets. Here, we review recent findings, which identified CalDAG-GEFI as a critical Ca2+ sensor that links increases in intracellular Ca2+ to integrin activation, TxA2 formation, and granule release in stimulated platelets. Furthermore, we summarize work that lead to the discovery of STIM1 and Orai1 as key regulators of store-operated calcium entry (SOCE) in platelets. A short discussion on the usefulness of each molecule as a potential new target for antiplatelet therapy is included." @default.
• W2062213947 created "2016-06-24" @default.
• W2062213947 creator A5050638577 @default.
• W2062213947 creator A5073613118 @default.
• W2062213947 date "2009-07-01" @default.
• W2062213947 modified "2023-09-30" @default.
• W2062213947 title "Novel molecules in calcium signaling in platelets" @default.
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• W2062213947 doi "https://doi.org/10.1111/j.1538-7836.2009.03379.x" @default.
• W2062213947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19630797" @default.
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