FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062214897> ?p ?o ?g. }

• W2062214897 endingPage "207" @default.
• W2062214897 startingPage "203" @default.
• W2062214897 abstract "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in tumor cells without toxicity to normal cells, but some recombinant versions of TRAIL caused hepatocyte death. We generated fully human monoclonal antibodies (mAbs) that bind specifically to TRAIL receptor 1 (TRAIL-R1) and TRAIL receptor 2 (TRAIL-R2), which mediate apoptosis signal when they ligate with TRAIL, to investigate the contribution of each receptor to induce tumor cell apoptosis and hepatocyte toxicity. All of mAbs to TRAIL-R1 and TRAIL-R2 induced cell death in several cancer cell lines susceptible to TRAIL but not in human umbilical vein endothelial cells in vitro. Both anti-TRAIL-R1 mAbs and anti-TRAIL-R2mAbs also caused cell death in hepatocytes. However, a subset of mAbs to TRAIL-R2, which was characterized by the TRAIL blocking activity, did not show strong hepatocyte toxicity. These results indicate that human normal hepatocytes are susceptible to both TRAIL-R1- and TRAIL-R2-mediated apoptosis signal. Cell Death and Differentiation (2004) 11, 203-207. doi:10.1038/sj.cdd.4401331 Published online 24 October 2003" @default.
• W2062214897 created "2016-06-24" @default.
• W2062214897 creator A5001471266 @default.
• W2062214897 creator A5009151280 @default.
• W2062214897 creator A5012371350 @default.
• W2062214897 creator A5033807322 @default.
• W2062214897 creator A5040437196 @default.
• W2062214897 creator A5045747449 @default.
• W2062214897 creator A5068445821 @default.
• W2062214897 creator A5076691658 @default.
• W2062214897 date "2003-10-24" @default.
• W2062214897 modified "2023-10-09" @default.
• W2062214897 title "Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2" @default.
• W2062214897 cites W1484817497 @default.
• W2062214897 cites W1594149454 @default.
• W2062214897 cites W1599806854 @default.
• W2062214897 cites W1975291295 @default.
• W2062214897 cites W1984709119 @default.
• W2062214897 cites W2014380713 @default.
• W2062214897 cites W2016417780 @default.
• W2062214897 cites W2056217426 @default.
• W2062214897 cites W2061142243 @default.
• W2062214897 cites W2088291142 @default.
• W2062214897 cites W2089458132 @default.
• W2062214897 cites W2089476060 @default.
• W2062214897 cites W2092508425 @default.
• W2062214897 cites W2102986716 @default.
• W2062214897 cites W2105186639 @default.
• W2062214897 cites W2106284224 @default.
• W2062214897 cites W2113505777 @default.
• W2062214897 cites W2119326933 @default.
• W2062214897 cites W2130988210 @default.
• W2062214897 doi "https://doi.org/10.1038/sj.cdd.4401331" @default.
• W2062214897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14576771" @default.
• W2062214897 hasPublicationYear "2003" @default.
• W2062214897 type Work @default.
• W2062214897 sameAs 2062214897 @default.
• W2062214897 citedByCount "71" @default.
• W2062214897 countsByYear W20622148972012 @default.
• W2062214897 countsByYear W20622148972013 @default.
• W2062214897 countsByYear W20622148972015 @default.
• W2062214897 countsByYear W20622148972016 @default.
• W2062214897 countsByYear W20622148972018 @default.
• W2062214897 crossrefType "journal-article" @default.
• W2062214897 hasAuthorship W2062214897A5001471266 @default.
• W2062214897 hasAuthorship W2062214897A5009151280 @default.
• W2062214897 hasAuthorship W2062214897A5012371350 @default.
• W2062214897 hasAuthorship W2062214897A5033807322 @default.
• W2062214897 hasAuthorship W2062214897A5040437196 @default.
• W2062214897 hasAuthorship W2062214897A5045747449 @default.
• W2062214897 hasAuthorship W2062214897A5068445821 @default.
• W2062214897 hasAuthorship W2062214897A5076691658 @default.
• W2062214897 hasBestOaLocation W20622148971 @default.
• W2062214897 hasConcept C121608353 @default.
• W2062214897 hasConcept C1491633281 @default.
• W2062214897 hasConcept C153911025 @default.
• W2062214897 hasConcept C159654299 @default.
• W2062214897 hasConcept C170493617 @default.
• W2062214897 hasConcept C178790620 @default.
• W2062214897 hasConcept C17991360 @default.
• W2062214897 hasConcept C185592680 @default.
• W2062214897 hasConcept C190283241 @default.
• W2062214897 hasConcept C202751555 @default.
• W2062214897 hasConcept C203014093 @default.
• W2062214897 hasConcept C2776200302 @default.
• W2062214897 hasConcept C2777411675 @default.
• W2062214897 hasConcept C29730261 @default.
• W2062214897 hasConcept C31573885 @default.
• W2062214897 hasConcept C502942594 @default.
• W2062214897 hasConcept C503630168 @default.
• W2062214897 hasConcept C542903549 @default.
• W2062214897 hasConcept C54355233 @default.
• W2062214897 hasConcept C55493867 @default.
• W2062214897 hasConcept C81885089 @default.
• W2062214897 hasConcept C86803240 @default.
• W2062214897 hasConcept C95444343 @default.
• W2062214897 hasConcept C96232424 @default.
• W2062214897 hasConceptScore W2062214897C121608353 @default.
• W2062214897 hasConceptScore W2062214897C1491633281 @default.
• W2062214897 hasConceptScore W2062214897C153911025 @default.
• W2062214897 hasConceptScore W2062214897C159654299 @default.
• W2062214897 hasConceptScore W2062214897C170493617 @default.
• W2062214897 hasConceptScore W2062214897C178790620 @default.
• W2062214897 hasConceptScore W2062214897C17991360 @default.
• W2062214897 hasConceptScore W2062214897C185592680 @default.
• W2062214897 hasConceptScore W2062214897C190283241 @default.
• W2062214897 hasConceptScore W2062214897C202751555 @default.
• W2062214897 hasConceptScore W2062214897C203014093 @default.
• W2062214897 hasConceptScore W2062214897C2776200302 @default.
• W2062214897 hasConceptScore W2062214897C2777411675 @default.
• W2062214897 hasConceptScore W2062214897C29730261 @default.
• W2062214897 hasConceptScore W2062214897C31573885 @default.
• W2062214897 hasConceptScore W2062214897C502942594 @default.
• W2062214897 hasConceptScore W2062214897C503630168 @default.
• W2062214897 hasConceptScore W2062214897C542903549 @default.
• W2062214897 hasConceptScore W2062214897C54355233 @default.
• W2062214897 hasConceptScore W2062214897C55493867 @default.
• W2062214897 hasConceptScore W2062214897C81885089 @default.

• next