FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062215511> ?p ?o ?g. }

• W2062215511 endingPage "102" @default.
• W2062215511 startingPage "96" @default.
• W2062215511 abstract "Drug-induced phototoxicity is a non-immunological inflammatory skin reaction, caused by concurrent topical or systemic exposure to a specific molecule and ultraviolet radiation. Most of phototoxic compounds absorb energy particularly from UVA light leading to activated derivatives, which can induce cellular damage. This type of adverse cutaneous response can be reproduced, in vitro, using human skin models. In this study, we investigated the ability of human reconstituted epidermis Episkin to assess skin phototoxicity of weak phototoxic compounds such as 6-methylcoumarin and ofloxacin, compared to a strong one, chlorpromazine, and two negative controls (sodium dodecyl sulphate (SDS), sulisobenzone).: After 1 h incubation with five test concentrations of each chemical compound, epidermis was then exposed or not to UVA at a non-cytotoxic dose (50 J/cm2). 18 h after UVA exposure, cellular damage was evaluated measuring cytotoxicity by MTT conversion test; in addition, pro-inflammatory mediator IL-1alpha release was also investigated.Topical pretreatment of Episkin, with weak phototoxic compounds induced, after UVA exposure, a dose-dependent decrease in cell viability, in concordance with an increasing IL-1alpha release. Moreover, compared to chlorpromazine, the lower IL-1alpha release observed with 6-methylcoumarin and ofloxacin could be linked to their weak phototoxic potential.Human reconstituted epidermis Episkin can be useful to study in vitro the onset of cutaneous phototoxic reactions and particularly to identify weak phototoxic compounds." @default.
• W2062215511 created "2016-06-24" @default.
• W2062215511 creator A5014850832 @default.
• W2062215511 creator A5023417538 @default.
• W2062215511 creator A5052015353 @default.
• W2062215511 creator A5084615000 @default.
• W2062215511 creator A5088230615 @default.
• W2062215511 date "2002-04-01" @default.
• W2062215511 modified "2023-09-23" @default.
• W2062215511 title "Use of human reconstituted epidermis Episkin�� for assessment of weak phototoxic potential of chemical compounds" @default.
• W2062215511 cites W1971905338 @default.
• W2062215511 cites W1976725149 @default.
• W2062215511 cites W1987925979 @default.
• W2062215511 cites W1993515016 @default.
• W2062215511 cites W1998700528 @default.
• W2062215511 cites W2007574050 @default.
• W2062215511 cites W2028770354 @default.
• W2062215511 cites W2039436358 @default.
• W2062215511 cites W2049921327 @default.
• W2062215511 cites W2055461946 @default.
• W2062215511 cites W2079388974 @default.
• W2062215511 cites W2081293311 @default.
• W2062215511 cites W2090778313 @default.
• W2062215511 cites W2092342210 @default.
• W2062215511 cites W2103136816 @default.
• W2062215511 cites W2114918609 @default.
• W2062215511 cites W2119360374 @default.
• W2062215511 cites W2131385834 @default.
• W2062215511 cites W2159673794 @default.
• W2062215511 cites W2183702510 @default.
• W2062215511 cites W275246717 @default.
• W2062215511 doi "https://doi.org/10.1034/j.1600-0781.2002.180207.x" @default.
• W2062215511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12147043" @default.
• W2062215511 hasPublicationYear "2002" @default.
• W2062215511 type Work @default.
• W2062215511 sameAs 2062215511 @default.
• W2062215511 citedByCount "46" @default.
• W2062215511 countsByYear W20622155112012 @default.
• W2062215511 countsByYear W20622155112013 @default.
• W2062215511 countsByYear W20622155112014 @default.
• W2062215511 countsByYear W20622155112015 @default.
• W2062215511 countsByYear W20622155112016 @default.
• W2062215511 countsByYear W20622155112017 @default.
• W2062215511 countsByYear W20622155112018 @default.
• W2062215511 countsByYear W20622155112019 @default.
• W2062215511 countsByYear W20622155112020 @default.
• W2062215511 countsByYear W20622155112021 @default.
• W2062215511 countsByYear W20622155112022 @default.
• W2062215511 crossrefType "journal-article" @default.
• W2062215511 hasAuthorship W2062215511A5014850832 @default.
• W2062215511 hasAuthorship W2062215511A5023417538 @default.
• W2062215511 hasAuthorship W2062215511A5052015353 @default.
• W2062215511 hasAuthorship W2062215511A5084615000 @default.
• W2062215511 hasAuthorship W2062215511A5088230615 @default.
• W2062215511 hasConcept C105702510 @default.
• W2062215511 hasConcept C109316439 @default.
• W2062215511 hasConcept C185592680 @default.
• W2062215511 hasConcept C202751555 @default.
• W2062215511 hasConcept C20639190 @default.
• W2062215511 hasConcept C2776458125 @default.
• W2062215511 hasConcept C2777459323 @default.
• W2062215511 hasConcept C2778775820 @default.
• W2062215511 hasConcept C53227056 @default.
• W2062215511 hasConcept C54355233 @default.
• W2062215511 hasConcept C55493867 @default.
• W2062215511 hasConcept C71924100 @default.
• W2062215511 hasConcept C86803240 @default.
• W2062215511 hasConcept C98274493 @default.
• W2062215511 hasConceptScore W2062215511C105702510 @default.
• W2062215511 hasConceptScore W2062215511C109316439 @default.
• W2062215511 hasConceptScore W2062215511C185592680 @default.
• W2062215511 hasConceptScore W2062215511C202751555 @default.
• W2062215511 hasConceptScore W2062215511C20639190 @default.
• W2062215511 hasConceptScore W2062215511C2776458125 @default.
• W2062215511 hasConceptScore W2062215511C2777459323 @default.
• W2062215511 hasConceptScore W2062215511C2778775820 @default.
• W2062215511 hasConceptScore W2062215511C53227056 @default.
• W2062215511 hasConceptScore W2062215511C54355233 @default.
• W2062215511 hasConceptScore W2062215511C55493867 @default.
• W2062215511 hasConceptScore W2062215511C71924100 @default.
• W2062215511 hasConceptScore W2062215511C86803240 @default.
• W2062215511 hasConceptScore W2062215511C98274493 @default.
• W2062215511 hasIssue "2" @default.
• W2062215511 hasLocation W20622155111 @default.
• W2062215511 hasLocation W20622155112 @default.
• W2062215511 hasOpenAccess W2062215511 @default.
• W2062215511 hasPrimaryLocation W20622155111 @default.
• W2062215511 hasRelatedWork W1526437440 @default.
• W2062215511 hasRelatedWork W1586890816 @default.
• W2062215511 hasRelatedWork W2005855934 @default.
• W2062215511 hasRelatedWork W2039047912 @default.
• W2062215511 hasRelatedWork W2054720663 @default.
• W2062215511 hasRelatedWork W2183702510 @default.
• W2062215511 hasRelatedWork W2418204567 @default.
• W2062215511 hasRelatedWork W2693020771 @default.
• W2062215511 hasRelatedWork W275246717 @default.
• W2062215511 hasRelatedWork W3009201734 @default.
• W2062215511 hasVolume "18" @default.

• next